The main interest of ShoshkesCarmelab is to understand the Telocyte. We study this using mammalian intestine as a model system. Telocytes are large stromal cells characterized by long cytoplasmic processes, have recently emerged as an important source of Wnt proteins, providing crucial support for intestinal stem cell renewal. Current projects are concerned with understanding telocytes in:
We are recruiting passionate excellent curious students and postdocs
Shoshkes-Carmel M, Wang YJ, Wangensteen KJ, Tóth B, Kondo A, Massasa EE, Itzkovitz S, Kaestner KH. Subepithelial telocytes are an important source of Wnts that support intestinal crypts. Nature 2018 May 2.
Dou Z, Ghosh K, Vizioli MG, Zhu J, Sen P, Wangensteen KJ, Simithy J, Lan Y, Lin Y, Zhou Z, Capell BC, Xu C, Xu M, Kieckhaefer JE, Jiang T, Shoshkes-Carmel M, Tanim KMAA, Barber GN, Seykora JT, Millar SE, Kaestner KH, Garcia BA, Adams PD, Berger SL. Cytoplasmic chromatin triggers inflammation in senescence and cancer. Nature. 2017 Oct 4.
Aoki R*, Shoshkes-Carmel M*, Gao N, Shin S, May CL, Golson ML, Zahm AM, Ray M, Wiser CL, Wright CV, Kaestner KH. Foxl1-expressing mesenchymal cells constitute the intestinal stem cell niche. Cell Mol Gastroenterol Hepatol 2016 2(2), 175-188. Selected for cover
Carmel MS., Kahane N., Oberman F., Miloslavski R., Sela-Donenfeld D., Kalcheim C., Yisraeli JK. A novel role for VICKZ proteins in maintaining epithelial integrity during embryogenesis. PLoS One 2015 10(8); e0136408
Almeida, R., Almeida, J., Shoshkes, M., Mendes, N., Mesquita, P., Silva, E., Van Seuningen, E., Reis, C., Santos-Silva, F., David , L. OCT-1 is over-expressed in intestinal metaplasia and intestinal gastric carcinomas and binds to, but does not transactivate, CDX2 in gastric cells. J pathol 2005 207, 396-401.
Ben-Shushan,E., Marshak, S., Shoshkes, M., Cerasi, E. & Melloul, D. A pancreatic beta-cell-specific enhancer in the human pdx-1 gene is regulated by HNF-3β, HNF-1α and SPs transcription factors. J Biol Chem 2001 276, 17533-17540.
Marshak, S., Ben-Shushan, E., Shoshkes, M., Havin, L., Cerasi, E. & Melloul, D. Regulatory elements involved in human pdx-1 gene expression. Diabetes 2001 Feb; 50 Suppl 1: S37-8.
Marshak, S., Ben-Shushan, E., Shoshkes, M., Leibovitz, G., Kaiser, N., Gross, D., Bertuzzi, F., Cerasi, E. & Melloul, D. (2001). Beta-cell-specific expression of insulin and pdx-1 genes. Diabetes Feb;50 Suppl 1: S131-2.
Marshak, S., Ben-Shushan, E., Shoshkes, M., Havin, L., Cerasi, E. & Melloul, D. (2000) Functional conservation of regulatory elements in the pdx-1 gene: PDX-1 and HNF-3β transcription factors mediate beta-cell-specific expression. Mol Cell Biol. 2000 Oct;20(20):7583-90.