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  • Prof.  Boaz Tirosh
Scientific interests
· To explore the effector functions of XBP-1 on the synthesis and breakdown of glycoproteins.
To investigate the role of XBP-1 degradation in plasma cell function in vitro and in vivo. We shall establish mouse models of plasmacytoma that enable the manipulation of XBP-1 stability. These models will be used to assess the sensitivity to treatment with anti-multiple myeloma drugs.
· To identify genes responsible for resistance to bortezomib, and explore their underlying mechanism of action.
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