· To explore the effector functions of XBP-1 on the synthesis and breakdown of glycoproteins.
· To investigate the role of XBP-1 degradation in plasma cell function in vitro and in vivo. We shall establish mouse models of plasmacytoma
that enable the manipulation of XBP-1 stability. These models will be used to assess the sensitivity to treatment with anti-multiple myeloma
· To identify genes responsible for resistance to bortezomib, and explore their underlying mechanism of action.