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Researchers
  • Dr.  Boaz Tirosh
 
Scientific interests

 

        ·       To explore the effector functions of XBP-1 on the synthesis and breakdown of glycoproteins.
 
        ·       To investigate the role of XBP-1 degradation in plasma cell function in vitro and in vivo. We shall establish mouse models of plasmacytoma
                that enable the manipulation of XBP-1 stability. These models will be used to assess the sensitivity to treatment with anti-multiple myeloma
                drugs.
 
        ·       To identify genes responsible for resistance to bortezomib, and explore their underlying mechanism of action.
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