Severe exposure of cells to genotoxic or metabolic stresses may result in transient changes in the cell cycle, cell death, changes in autophagy, senescence or a different cell fate. The cellular response balancing between the extent of damage and the adequate cell fate serves as a barrier preventing the development of diseases such as cancer. The appropriate response to stress is also used as a major mechanism in cancer therapy. We study the cellular responses to stress and exploring factors regulating different cell fates as well as cellular proliferation and homeostasis. Our aim is to shed light on novel regulation mechanisms in order to improve the outcome of therapy.