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Researchers
  • Prof.  Eli Breuer
Prof Eli Breuer
 
Scientific Interest  
      ·       The design and synthesis of new types of inhibitors of matrix metalloproteinases involved in connective tissue disorders.
        ·       The design and synthesis of new types of chemosensitizers for reversing multidrug resistance.
 
  
Chapters in Books 
E. Breuer, Acylphosphonates and their derivatives, in The chemistry of organophosphorus compounds Vol 4, Edited by F. R. Hartley, 1996, John Wiley Sons, Ltd. pp 653-729.
 
E. Breuer, The development of bisphosphonates as drugs, in "Analog-based Drug Discovery" Fischer, J. and Ganellin, C. R. (eds.) 2005 Wiley-VCH, Weinheim, Germany, in press.
 
 
Patents 
E. Breuer and G. Golomb, Bisphosphonates, processes for preparation and pharmaceutical compositions containing the same (US # 5,196,409, 1993).
 
E. Breuer and G. Golomb, Bisphosphonates, processes for preparation and pharmaceutical compositions containing the same (US # 5,338, 731, 1994).
 
E. Breuer, G. Golomb, A. Schlossman, Bis - and tetrakis-phosphonates useful for treating calcium-related disorders (US # 5,312,954, 1994, abandoned).
 
E. Breuer, G. Golomb, I.S. Alferiev, A. Ornoy, Novel bisphosphonates, process for their preparation and pharmaceutical compositions containing them (IL0115041, and WO9708178, 1995).
 
E. Breuer, G. Golomb, G.L. Amidon, I. Alferiev, N. El-Hanany Rozen, A. Friedman-Ezra, Phosphonates and bisphosphonates and pharmaceutical compositions containing them (IL113246, 1995).
 
E. Breuer, G. Golomb, G.L. Amidon, I. Alferiev, N. El-Hanany Rozen, A. Friedman-Ezra, Phosphonates, bisphosphonates and pharmaceutical compositions containing them (PCT, WO9631227, 1996, US 6, 541,454, 2003.
 
E. Breuer, R. Reich and C. J. Salomon, Compositions comprising oxophosphonate – based metalloproteinase inhibitors, PCT Int. Appl., WO 01 26661. Chem. Abstr. 2001, 134: 311432j.
 
E. Breuer, R. Reich, G. Golomb, Y. Katz, New carbamoyl and thio-carbamoyl-phosphonates and pharmaceutical compositions containing them (US provisional patent, and PCT application, PCT/IL2004/000302, 2003.
 
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