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Researchers
  • Prof.  Esty Shohami
Prof  Esty Shohami
 
Research interests
  1. The pathophysiology of traumatic brain injury (TBI): mechanisms of damage and repair of motor and cognitive deficits.
    • The role of neuroinflammation in the post-injury secondary damage
    • The role of the NMDA receptors in the cognitive decline after TBI
    • Mechanisms for the repair of learning and memory deficits after TBI
  2. The role of cannabinoids in the recovery of motor and cognitive functions after traumatic brain injury (TBI)
    • Effect of cannabinoids (synthetic, plant- or brain- derived) on the recovery of function and on neurogenesis after TBI.
    • Mechanism of action of endocannabinoids as neuroprotective and neuroregenerative molecules.
Scientific Biography
Esther Shohami has received her doctorate in Physiology from the Hebrew University (HU), Jerusalem, Israel and did her post-doc at MC-Gill University in Montreal, Canada. She later joined the HU School of Pharmacy at the faculty of medicine, and is currently a Professor Emerita in Pharmacology, at the HU Institute for Drug Research. Between 2006 - 2011 she served as the Dean of students at her University, and between 2012-2014 as the president of the Israel Society for Neuroscience. She is a member of the executive board of the International Neurotrauma Society (INTS) and serves at the editorial boards of J. Neurotrauma. She also served as council member in the US National Neurotrauma Society and at the editorial board of J. CBF&M.
Prof. Shohami has published more than 220 articles, reviews and book chapters. Her research is focused on experimental traumatic brain injury (TBI) in rodents and addresses mechanisms of injury (e.g inflammation, oxidative stress, the glutamate NMDAR) and endogenous neuroprotection (e.g. endocannabinoids and heat-acclimation induced preconditioning). Currently her work is focused on the effects of TBI on cognitive functions and on mechanisms that are involved in ameliorating these TBI-induced deficits. She also studies the involvement of the endocannabinoid system in the pathophysiology and rehabilitation after TBI, and is involved in the development of cannabinoid like novel drugs for TBI.
Selected publications
Chen Y., Constantini S., Trembovler V., Weinstock M., and Shohami E. An Experimental model of closed head injury in mice: Pathophysiology, histopathology and cognitive deficits. J. Neurotrauma. 13: 557-568, 1996
Panikashvili, D, Simeonidou, C., Ben-Shabat, S., Hanuš, L., Breuer, A., Mechoulam, R., and Shohami E. 2-Arachidonoyl Glycerol, an Endogenous Cannabinoid, is Neuroprotective After Brain Injury. Nature, 413: 527-531, 2001.
Biegon A., Fry P.A., Paden C.M., Alexandrovich A., Tsenter J., Shohami E., Delayed Activation, rather than inhibition, of glutamate NMDA receptors improves neurological outcome after closed head injury in mice. Proc Natl Acad Sci USA 101:5117-5122, 2004
Panikashvili D, Mechoulam R, Beni SM, Alexandrovich A, Shohami E. CB(1) cannabinoid receptors are involved in neuroprotection via NF-kappaB inhibition.. J Cereb Blood Flow Metabol 25:477-484, 2005
Yatsiv I, Grigoriadis N, Simeonidou C, Stahel PF, Schmidt OI, Alexandrovitch AG, Tsenter J, Shohami E. Erythropoietin is neuroprotective, improves functional recovery, and reduces neuronal apoptosis and inflammation in a rodent model of experimental closed head injury. FASEB J. 12:1701-1703. 2005
Panikashvili, D, Shein NA, Mechoulam R, Trembovler V, Kohen R, Alexandrovich A, and Shohami E. The Endocannabinoid 2-AG Protects the Blood Brain Barrier after Closed Head Injury and Inhibits Expression of Proinflammatory Cytokines. Neurobiology of Disease, 22:257-264, 2006
Tam J, Ofek O, Fride E, Ledent C, Gabet Y, Muller R, Zimmer A, Mackie K, Mechoulam R, Shohami E, Bab I. Involvement of Neuronal Cannabinoid Receptor, CB1, in Regulation of Bone Mass and Bone Remodeling. Mol Pharmacol. 70:786-792. 2006
Yaka R, Biegon A, Grigoriadis N, Simeonidou C, Grigoriadis S, Alexandrovich AG, Matzner H, Schumann J, Trembovler V, Tsenter J and Shohami E. D-cycloserine improves functional recovery and reinstates long-term potentiation (LTP) in a mouse model of closed head injury. FASEB J 21:2033-2041, 2007
Shein NA, Horowitz M, Shohami E. Heat acclimation: a unique model of physiologically mediated global preconditioning against traumatic brain injury. Prog Brain Res. 161:353-363, 2007
Mechoulam R. and Shohami E. Endocannabinoids and traumatic brain injury. Molecular Neurobiology, 36:68-74, 2007.
Flierl, M.A., Stahel, P.F, Beauchamp, K.M., Morgan, S.J, Smith, W.R, Shohami E. Mouse closed head injury model induced by a weight-drop device.. Nat Protoc. 2009;4(9):1328-1337.
Thau-Zuchman, O, Shohami E, Alexandrovich A.G., Leker, R.R. Combination of Vascular Endothelial and Fibroblast Growth Factor 2 for Induction of Neurogenesis and Angiogenesis after Traumatic Brain Injury. J Mol Neurosci 47:166-172, 2012
Umschweif G., Shabashov D., Alexandrovich A.G, Trembovler V, Horowitz M., Shohami E. Neuroprotection following TBI in heat acclimated mice involves induced neurogenesis and activation of angiotensin receptor type 2 signaling. J Cereb Blood Flow Metabol. 34:1381-1390, 2014.
Liraz-Zaltsman, S., Yaka R., Shabashov, D., Shohami E., Biegon, A. Neuroinflammation-Induced Memory Deficits Are Amenable to Treatment with D-Cycloserine. J Mol Neurosci 60:46-62, 2016 DOI 10.1007/s12031-016-0786-8

Cannabinoid-related publications

Chen, Y., McCarron, RM., Ohara, Y., Bembry J, Azzam, N., Lenz, FA., Shohami E, Mechoulam, R. and Spatz, M. A Novel Functional Interaction Between 2-Arachidonoglycerol, an Endocannabinoid, and Endothelin-1 in Human Brain Capillary Endothelium. Circ Res. 87: 323-327, 2000
Panikashvili, D, Simeonidou, C., Ben-Shabat, S., Hanuš, L., Breuer, A., Mechoulam, R., and Shohami E. 2-Arachidonoyl Glycerol, an Endogenous Cannabinoid, is Neuroprotective After Brain Injury. Nature, 413: 527-531, 2001
McCarron RM, Shohami E, Panikashvili D, Chen Y, Golech S, Strasser A, Mechoulam R, Spatz M.Antioxidant properties of the vasoactive endocannabinoid, 2-arachidonoyl glycerol (2-AG). Acta Neurochir Suppl. 86:271-275. 2003
Golech SA, McCarron RM, Chen Y, Bembry J, Lenz F, Mechoulam R, Shohami E, Spatz M. Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors. Brain Res Mol Brain Res. 132:87-92, 2004
Panikashvili D, Mechoulam R, Beni SM, Alexandrovich A, Shohami E. CB(1) cannabinoid receptors are involved in neuroprotection via NF-kappaB inhibition.. J Cereb Blood Flow Metabol 25:477-484, 2005
Ofek O, Karsak M, Leclerc N, Fogel M, Frenkel B, Wright K, Tam J, Attar-Namdar M, Kram V, Shohami E, Mechoulam R, Zimmer A, Bab I. Peripheral CB2 Cannabinoid Receptor Regulates Bone Mass. Proc Natl Acad Sci USA 103:696-701, 2006
Shohami E, Mechoulam R Multiple Sclerosis May Disrupt Endogenous Brain Protection Mechanism. Commentary, Proc Natl Acad Sci USA, 103:6087-6088, 2006
Panikashvili, D, Shein NA, Mechoulam R, Trembovler V, Kohen R, Alexandrovich A, and Shohami E. The Endocannabinoid 2-AG Protects the Blood Brain Barrier after Closed Head Injury and Inhibits Expression of Proinflammatory Cytokines. Neurobiology of Disease, 22:257-264, 2006
Tam J, Ofek O, Fride E, Ledent C, Gabet Y, Muller R, Zimmer A, Mackie K, Mechoulam R, Shohami E, Bab I. Involvement of Neuronal Cannabinoid Receptor, CB1, in Regulation of Bone Mass and Bone Remodeling. Mol Pharmacol. 70:786-792. 2006
McCarron RM, Chen Y, Tomori T, Strasser A, Mechoulam R, Shohami E, Spatz M. Endothelial-mediated regulation of cerebral microcirculation. J Physiol Pharmacol. 57 (Suppl) 11:133-144. 2006
Mechoulam R. and Shohami E. Endocannabinoids and traumatic brain injury. Molecular Neurobiology, 36:68-74, 2007
Tam J, Trembovler V, Di Marzo V, Petrosino S, Leo G, Alexandrovich AG, Regev E, Casap N, Shteyer A Ledent C, Karsak M, Zimmer A, Mechoulam R, Yirmiya R, Shohami E, Bab I. The Cannabinoid CB1 Receptor Regulates Bone Formation by Modulating Adrenergic Signaling. FASEB J. 22:285-294., 2008
Ofek O, Attar-Namdar M, Kram V, Dvir-Ginzberg M, Mechoulam R, Zimmer A, Frenkel B, Shohami E, Bab I. (2010). CB2 cannabinoid receptor targets mitogenic Gi protein - cyclin D1 axis in osteoblasts. J Bone Miner Res. J. Bone Min. Res., 26: 308-316, 2011
Shohami E., Cohen-Yeshurun, A., Magid, L., Elgali, M., and Mechoulam, R. Endocannabinoids And Traumatic Brain Injury. review. Br. J. Phram, 163:1402-1410, 2011
Cohen-Yeshurun, A, Trembovler, V., Alexandrovich, A., Ryberg, E., Greasley, P.J., Mechoulam, R., Shohami E., and Leker, R.R. N-Arachidonoyl-L-Serine is Neuroprotective after Traumatic Brain Injury by Reducing Apoptosis. J Cereb Blood Flow Metabol. 31:1768-1777, 2011
Lourbopoulos A, Grigoriadis N, Lagoudaki R, Touloumi O, Polyzoidou E, Mavromatis I, Tascos N, Breuer A, Ovadia H, Karussis D, Shohami E, Mechoulam R, Simeonidou C. Administration of 2-arachidonoylglycerol ameliorates both acute and chronic experimental autoimmune encephalomyelitis. Brain Res. 16;1390:126-141, 2011
Cohen-Yeshurun A, Willner D, Trembovler V, Alexandrovich A, MechoulamR, Shohami E, Leker R.R. N-arachidonoyl-L-serine (AraS) possesses proneurogenic properties in vitro and in vivo after traumatic brain injury. J Cereb Blood Flow & Metabol. 33:1242-1250, 2013
Hanuš L., Shohami E., Bab I., Mechoulam R., N-Acyl amino acids and their impact on biological processes. Biofactors. 40:381-388, 2014
Mann A, Smoum R, Trembovler V, Alexandrovich A, Breuer A, Mechoulam R, Shohami E. Palmitoyl Serine: An Endogenous Neuroprotective Endocannabinoid-Like Entity After Traumatic Brain Injury. J Neuroimmune Pharmacol. 10:356-363, 2015
Mann A, Cohen-Yeshurun A, Trembovler V, Mechoulam R, Shohami E. Are the endocannabinoid-like compounds N-acyl aminoacids neuroprotective after traumatic brain injury? J Basic Clin Physiol Pharmacol. 27(3): 209-216, 2016. doi: 10.1515/jbcpp-2015-0092
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