Main Research Topics
The lab neurobiological research focuses on understanding neurological psychiatric diseases and on developing novel therapeutic approaches for them. Our basic hypothesis is that alterations in the neuronal communication (i.e., changes in neuronal networks) are responsible or are the consequences of the diseases. We hypothesize that identification of circuitry alterations can be used for diagnosis or for monitoring treatments. Furthermore, we believe that invasive alterations of brain communication (by for example deep brain stimulation) can 'correct' such circuits for the benefit of the patients. Specifically we focus on depression (on its many faces) and on Parkinson disease.
Experimental approach The lab main tool is the noninvasive functional connectivity MRI (fcMRI) and the functional MRI (fMRI) methods. In addition we use the invasive manganese enhance MRI method (MEMRI). FcMRI is used to estimate effective neuronal connectivity and to obtain network representations in humans and in rats. This can be obtained during rest and during emotional arousal states. FMRI is used to obtain an internal measure of the patient arousal state. The MEMRI method is used on rats. It gives the direct effective connectivity of a predefined neuronal target.
The following are now being studying:
• Reproductive depression (mood changes due to hormonal fluctuations in females)
• Cluster network analysis to identify best location for DBS in depression
• Mild cognitive impairments in Parkinson's disease patients
• Brain representation of PTSD patients
• The critical role of the habenula in depression – a study on chronic mild stress rat model.
• Brain representation of 6-OHDA injected rats (a rat model of Parkinson's disease) before and after STN DBS
• Circuitry alterations in prenatal stress rats and the effect of treatment to their mothers.
• Understanding the effect of rapid antidepressant treatment – study on different rat models for depression
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last 5 years
Gadi Goelman, Galit Pelled, Steave Dodd and Alan Koretsky, (2007) - "Observation of two distinct spatial-temporal BOLD clusters during sensory stimulation using the Radial-Correlation-Contrast method", NeuroImage, 34(3): 1220-6
Gideon Kipervaser, Galit Pelled, and Gadi Goelman, (2007) "Statistical framework and noise sensitivity of the Amplitude- Radial-Correlation-Contrast method", MRM Sep;58(3):554-61
Gadi Goelman, Liu Songtao, Fleysher Roman, Fleysher Lazer, Grosman Robert and Oded Gonen (2007), "CHEMICAL-SHIFT ARTIFACT REDUCTION IN HADAMARD-ENCODED MR SPECTROSCOPIC IMAGING AT HIGH, 3 T AND 7 T, MAGNETIC FIELDs", MRM, 58(1):167-73
Daniele Marciano, Ester Shohami, Yoel Kloog, Alexander Alexandrovich, Rachel Brandeis and Gadi Goelman, (2007) "Neuroprotective Effects of the Ras Inhibitor S-Trans-Trans-Farnesylthiosalicylic Acid, Measured by Diffusion-Weighted Imaging after Traumatic Brain Injury in Rats", Journal of Neurotrauma Aug;24(8):1378-86
Galit Pelled, Hagai Bergmann, Tamir Ben-Hur and Gadi Goelman,(2007) “Manganese-Enhanced MRI in a rat model of Parkinson’s disease”, JMRI Oct;26(4):863-70.
Atira Bick, Gadi Goelman and Ram Frost, (2008) "Neural Correlates of Morphological Processes in Hebrew", J. cognitive neuroscience, Mar, 20(3); 406-20
Shtarkshall Revital, Bergman Haga, and Goelman Gadi , (2008) " Evidence for the coexistence of segregated and integrated functional connections from the striatum to the substantia nigra in rats", NeuroImage, 40(2);451-7
O. Gonen, S. Liu, G. Goelman, E.M. Ratai, M.R. Lentz and R.G. Gonzalez, (2008), "Proton MR Spectroscopic Imaging of in vivo Rhesus Macaque Brain at 7 Tesla " – Magnetic resonance in medicine, 59(4);492-9
Gadi Goelman, Galit Pelled, Steve Dodd and Alan Koretsky, (2008) "Tracking the effects of crusher gradients on gradient-echo BOLD signal in space and time during rat sensory stimulation" , Magnetic resonance in medicine, 60(3), 548-54
Atira Bick, Ram Frost and Gadi Goelman, (2010) "Imaging Implicit Morphological Processing: Evidence from Hebrew", Journal of Cognitive Neuroscience 22, 9, 1955-1969
Omer Doron and Gadi Goelman, (2010)“Evidence for asymmetric intra substantia nigra functional connectivity – Application to basal ganglia processing" NeuroImage Feb 15;49(4):2940-6
Fanne RA.(C), Nassar T. (T), Mazuz A.(S), Waked O.(c), Heyman SN. (C) , Hijazi N.(C), Goelman G(C)., Higazi AA.(PI)," Neuroprotection by glucagon: role of gluconeogenesis", (2011), J Neurosurg. Jan;114(1):85-91
Bick A.(s), Goelman G.(PI) and Frost R. (PI), (2011) "Hebrew brain vs. English brain: Language modulates the way it is processed" , J Cogn Neurosci. 2011 Sep;23(9):2280-90
Tal A, Goelman G and Gonen O, "In vivo FID-based 3D Multivoxel Longitudinal Hadamard Spectroscopic Imaging In the Human Brain at 3T", (2012), Magn Reson Med. 2012 May 10.
Daphna Sourani, Renana Eitan, Noam Gordon and Gadi Goelman (2012). "Habenula couples the dopaminergic and the serotonergic systems - Application to depression in Parkinson’s disease", Eur J Neurosci. 2012 Sep;36(6):2822-9.
Uri Cohen, Asaf Tal Gadi Goelman and Oded Gonen (2012)," Non-spin-Echo 3D Transverse Hadamard Encoded Proton Spectroscopic Imaging in the Human Brain" MRM Aug 24.
Ido Davidesco, Michal Harel, Michal Ramot, Uri Kramer, Svetlana Kipervasser, Fani Andelman, Miri Neufeld, Gadi Goelman, Itzhak Fried, and Rafael Malach, "Spatial and object-based attention modulates broadband Gamma responses across the human visual cortical hierarchy" JNS accepted