Born 1945, Saratov, USSR
Ph.D. 1976, Hebrew Univ.
Sen. Lect. 1992
Field of Study
Molecular mechanisms involved in the processes of endocytosis and exocytosis in hormone secreting cells:
The ultimate requirement for calcium ions in secretion of both hormones and neurotransmitters has been known since decades. Nevertheless, the particular molecular processes in which calcium ions play a role is still unresolved, as is the cascade of events leading to the fusion of the vesicle and cell membranes. Recently, calcium has been shown to affect also the process of endocytosis, which probably uses a specific protein dynamin. In our lab we study endo- and exocytotic activity using the electrophysiology method of path-clamp capacitance recording.
Patch clamp recording of single channel activity
Whole cell recording of cell currents
Whole cell capacitance recording of endocytosis and exocytosis