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Researchers
  • Dr.  Iddo Ben-Dov
Dr. Iddo Ben-Dov
 
Current Research
In my current research, I hope to continue to study and contribute to both basic understanding of molecular mechanisms of disease and unmet health needs. The research of post-transcriptional regulators of gene expression is lagging behind other fields in molecular biology, despite obvious translational potential. I believe this is due to the complexity of interactions between RNA-binding proteins, non-coding RNA and their targets. I intend to apply and develop sophisticated tools to decipher the targets and function of RNA-binding proteins, with potential to contribute to the health of kidney patients.
 
Currently funded projects:
​1. ​Bicaudal-C RNA binding protein in human autosomal dominant polycystic kidney disease (ISF grant)
​2. ​Serum microRNA as biomarkers in patients with pheochromocytoma (GIF grant)
​3. ​MicroRNA in human parasitic infections (I-CORE funding)
​4. ​Circulating microRNA for the detection and management of human schistosomiasis (Kamin grant)
​5.
 
​Urine miRNA for the prediction of chronic kidney disease progression (NIH consortium grant through collaboration with the Tuschl lab, Rockefeller University)
​6. ​Urine H19 non-coding RNA in the detection of bladder cancer (BioCancell Ltd.)
 
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Selected publications
Original papers
Marx-Tibbon, S., Ben-Dov, I. and Willner, I. (1996). Electrochemical and quartz-crystalmicrobalance transduction of light-controlled supramolecular interactions at monolayer functionalized electrodes. J Am Chem Soc 118:4717-8.
 
Ben-Dov, I., Willner, I. and Zisman, E. (1997). Piezoelectric immunosensors for urine specimens of Chlamydia trachomatis employing quartz crystal microbalance microgravimetric analyses. Anal Chem 69:3506-12.
 
Blonder, R., Levi, S., Tao, G., Ben-Dov, I. and Willner, I. (1997). Development of amperometric and microgravimetric immunosensors and reversible immunosensors using antigen and photoisomerizable antigen monolayer electrodes. J Am Chem Soc 119:10467-78.
 
Sosna, J., Shulimzon, T., Roznman, J., Lidgi, M., Lavy, A., Ben-Dov, I.Z. and Ben-Dov, I. (1999). Drug-resistant pulmonary tuberculosis in Israel, a society of immigrants: 1985-1994. Int J Tuber Lung Dis 3:689-94.
 
Ben-Dov, I.Z., Ben-Arie, L., Mekler, J. and Bursztyn, M. (2005). In clinical practice, masked hypertension is as common as isolated clinic hypertension: Predominance of younger men. Am J Hypertens 18:589-93.
 
Elinav, E., Ben-Dov, I.Z., Hai-Am, E., Ackerman, Z. and Ofran, Y. (2005). The predictive value of admission and follow up factor V and VII levels in patients with acute hepatitis and coagulopathy. Journal of Hepatology 42:82-6.
 
Ben-Dov, I.Z., Ben-Arie, L., Mekler, J. and Bursztyn, M. (2006). How should patients treated with alpha-blockers be followed? Insights from an ambulatory blood pressure monitoring database. J Hypertens 24:861-5.
 
Ben-Dov, I.Z., Ben-Arie, L., Mekler, J. and Bursztyn, M. (2006). Normal ambulatory blood pressure: a clinical-practice-based analysis of recent American Heart Association recommendations. Am J Med 119:69.e13-8.
 
Elinav, E., Ben-Dov, I.Z., Shapira, Y., Daudi, N., Adler, R., Shouval, D. and Ackerman, Z. (2006). Acute hepatitis A infection in pregnancy is associated with high rates of gestational complications and preterm labor. Gastroenterology 130:1129-34.
 
Levi, R., Ben-Dov, I.Z., Lavi-Moshayoff, V., Dinur, M., Martin, D., Naveh-Many, T. and Silver, J. (2006). Increased parathyroid hormone gene expression in secondary hyperparathyroidism of experimental uremia is reversed by calcimimetics: Correlation with posttranslational modification of the trans acting factor AUF1. J Am Soc Nephrol 17:107-12.
 
Ben-Dov, I.Z., Ben-Ishay, D., Mekler, J., Ben-Arie, L. and Bursztyn, M. (2007). Increased prevalence of masked blood pressure elevations in treated diabetic subjects. Arch Intern Med 167:2139-42.
 
Ben-Dov, I.Z., Pappo, O., Sklair-Levy, M., Galitzer, H., Ilan, Y., Naveh-Many, T. and Silver, J. (2007). Lanthanum carbonate decreases PTH gene expression with no hepatotoxicity in uraemic rats. Nephrol Dial Transplant 22:362-8.
 
Ben-Dov, I.Z., Galitzer, H., Lavi-Moshayoff, V., Goetz, R., Kuro-o, M., Mohammadi, M., Sirkis, R., Naveh-Many, T. and Silver, J. (2007). The parathyroid is a target organ for FGF23 in rats. J Clin Invest 117:4003-8.
 
Ben-Dov, I.Z., Kark, J., Ben-Ishay, D., Mekler, J., Ben-Arie, L. and Bursztyn, M. (2007). Blunted heart rate dip during sleep and all-cause mortality. Arch Intern Med 167:2116-21.
 
Ben-Dov, I.Z., Kark, J., Ben-Ishay, D., Mekler, J., Ben-Arie, L. and Bursztyn, M. (2007). Predictors of all-cause mortality in clinical ambulatory monitoring - Unique aspects of blood pressure during sleep. Hypertension 49:1235-41.
 
Ben-Dov, I.Z., Mekler, J. and Bursztyn, M. (2008). Sex differences in ambulatory blood pressure monitoring. Am J Med 121:509-14.
 
Nechama, M., Ben-Dov, I.Z., Briata, P., Gherzi, R. and Naveh-Many, T. (2008). The mRNA decay promoting factor K-homology splicing regulator protein post-transcriptionally determines parathyroid hormone mRNA levels. Faseb Journal 22:3458-68.
 
Gavish, B., Ben-Dov, I.Z., Kark, J., Mekler, J. and Bursztyn, M. (2009). The association of a simple blood pressure-independent parameter derived from ambulatory blood pressure variability with short-term mortality. Hypertens Res 32:488-95.
 
Nechama, M., Ben-Dov, I.Z., Silver, J. and Naveh-Many, T. (2009). Regulation of PTH mRNA stability by the calcimimetic R568 and the phosphorus binder lanthanum carbonate in CKD. Am J Physiol-Ren Physiol 296:F795-F800.
 
Galitzer, H., Ben-Dov, I.Z., Silver, J. and Naveh-Many, T. (2010). Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease. Kidney International 77:211-8.
 
Ben-Dov, I.Z. and Kark, J.D. (2011). Serum uric acid is a GFR-independent long-term predictor of acute and chronic renal insufficiency: the Jerusalem Lipid Research Clinic cohort study. Nephrol Dial Transplant 26(8):2558-66.
 
Levi I.M., Ben-Dov I.Z., Klimov A., Pizov G., Bloom A.I. (2011). Transjugular kidney biopsy: enabling safe tissue diagnosis in high-risk patients. Isr Med Assoc J 13(7):425-427.
 
Ben-Dov I.Z., Muthukumar T., Sharma V., Ding R., Campagne F., Tuschl T., Suthanthiran M. (2012). MicroRNA Sequence Profiles of Human Kidney Allografts With or Without Tubulointerstitial Fibrosis. Transplantation 94(11):1086-1094.
 
Totary-Jain H., Sanoudou D., Ben-Dov I.Z., Dautriche C.N., Guarnieri P., Marx S.O., Tuschl T., Marks A.R. (2013). Reprogramming of the microRNA transcriptome mediates resistance to rapamycin. J Biol Chem 288(9):6034-44.
 
Ben-Dov I.Z.*, Williams, Z.*, Elias R., Brown M., Rosenwaks Z., Tuschl T. (2013). Comprehensive profiling of circulating microRNA via small RNA sequencing of cDNA libraries reveals biomarker potential and limitations. Proc Nat Acad Sci USA 110(11):4255-60 [*, equal contributors]
 
Ben-Dov IZ, Tan YC, Morozov P, Wilson PD, Rennert H, Blumenfeld JD, Tuschl T.  (2014). Urine microRNA as potential biomarkers of autosomal dominant polycystic kidney disease progression: description of miRNA profiles at baseline. PLoS One 9(1):e86856.
 
Lai, J.Y., Luo, J., O'Connor, C., Jing, X., Nair, V., Ju, W., Randolph, A., Ben-Dov, I.Z., Matar, R.N., Briskin, D., Zavadil, J., Nelson, R.G., Tuschl, T., Brosius, F.C. 3rd, Kretzler, M., Bitzer, M. (2015). MicroRNA-21 in glomerular injury. J Am Soc Nephrol [Epub ahead of print].
 
Reviews, commentaries, hypotheses, editorials
Galitzer, H., Ben-Dov, I.Z., Lavi-Moshayoff, V., Naveh-Many, T. and Silver, J. (2008). Fibroblast growth factor 23 acts on the parathyroid to decrease parathyroid hormone secretion. Curr Opin Nephrol Hypertens 17:363-7.
 
Bursztyn, M. and Ben-Dov, I.Z. (2009). White-Coat Hypertension Should Not Be Treated in Subjects With Diabetes. Diabetes Care 32:S310-S3.
 
Bitzer M., Ben-Dov I.Z., Thum T. (2012) Microparticles and microRNAs of endothelial progenitor cells ameliorate acute kidney injury. Kidney Int 82(4):375-7.
 
Farazi T.A., Brown M., Morozov P., Ten Hoeve J.J., Ben-Dov I.Z., Hovestadt V., Hafner M., Renwick N., Mihailović A., Wessels L.F., Tuschl T. (2012) Bioinformatic analysis of barcoded cDNA libraries for small RNA profiling by next-generation sequencing. Methods 58(2):171-187.  
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