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Researchers
  • Prof.  Israel Ringel
Prof Israel Ringel
 
Research Interest  
My main research interests are:
 
     1. The mechanism of action of anti cancer drugs the affect the microtubule system.
 
     2. The application of NMR methods for:
             a. Studies of drug protein and drug cell interactions
             b. Categorization of cancer cell properties via their metabolic composition.
             c. Assessing a possible correlation between neoplasm response to chemotherapy and cellular metabolic profile.
 
 
Research Projects 
     ·       The effect of microgravity on cytoskeleton structure and function, and on the effect of anti mitotic drugs.
 
     ·       The mechanism of action of anti cancer drugs that affect the microtubule system.
 
     ·       Characterization of cancer cell properties, metabolism and response to chemotherapy treatment,utilizing Nuclear Magnetic
            Resonance techniques.

  

Chapters and reviews in books and proceedings  
Ringel I., Taxol: Molecular Mechanisms, Paclitaxel in Cancer Treatment McGuire W.P. and Rowinsky E.K. editors , pp 35-44, Marcel Dekker, Inc. 1995.
 
Horwitz S.B., Rao S., Krauss N.E., Heerding J.M., Swindell C.S., Ringel I. and Orr G.A., Photoincorporation of paclitaxel photoaffinity analogue into the N-terminal 31 amino acids of ??-tubulin. Am. Chem. Soc, Taxane Anticancer Agents (Gunda I.G., Chen T.T., Ojima I. and Vyas D.M., editors), pp 154-161 (1995).
 
Domb A.J., Elmalak O., Shastri V., Ta-Shma Z., Masters D.M., Ringel I., Teomim D. and Langer R., Polyanhydrides, in: Handbook of Biodegradable Polymers (A. J. Domb, J. Kost, D. Wiseman, Eds, Gordon and Breach Science Publishers), pp. 135-159 (1997).
 
Shastri V., Hildgen P.P., Langer R., Najajrah Y., Ringel I. and Domb A.J., Other Polyesters, Handbook of Biodegradable Polymers (A. J. Domb, J. Kost, D. Wiseman, Eds, Gordon and Breach Science Publishers), pp.119-134 (1997).
 
 
 
Abstracts  
 
Carmi S., Cohen J.S., Edelmann D., Anteby S.O., Abramov Y. and Ringel I., Characterization of human ovarian cancer cell metabolites and response to chemotherapy by magnetic resonance spectroscopy, The Montebello Conference 2004.
 
Labay V., Ringel I. And Assaraf Y., Mutual exclusiveness of P-glycoprotein overexpression and Taxoid-dependence as predominant mechanisms of resistance to Taxol and Taxotere in multiple mammalian clonal variants, French-American Colloquium on the Cytoskeleton and Human Disease, Marseille, pp 60 2001.
 
Sterin M, Cohen J.S., Mardor Y. and Ringel I., Glycerophosphorylcholine Level as a Marker for Treatment Efficiency of Anti-Mitotic Drugs Against Breast Cancer Cells: A 31P Magnetic Resonance Spectroscopy Study, French-American Colloquium on the Cytoskeleton and Human Disease, Marseille, pp 85 2001.
 
Mardor Y., Weiss Y., Sterin M., Ruiz-Cabello, Ash E., Ringel I., Orenstein A., Kaplan O., Roth Y., Maier S. and Cohen J.S., Diffusion weighted Proton MRS and MRI applications to cancer, MR in experimental and clinical cancer research in the new millenium Norway, 10-13 August, 2000.
 
Mardor Y., Kaplan O., Sterin M., Ruiz-Cabello J., Ash E., Ringel I. and Cohen J.S., Breast cancer cell metabolism and oncologic pharmacology by diffusion weighted proton MRS, Annual meeting of the Am. Ass. Cancer Res. 2000.
 
Elhanati G., Ringel I., Panet R., Lichtstein D. and Atlan H., Possible involvement of cellular volume changes in the mitogenic response Annual meeting of the Israel Soc. Physiol. Parmacol. 1999.
 
Landskroner S., Lelkes P.I. and Ringel I., Differential alteration of microtubule organization in human fibrosarcoma cells exposed to hypergravity and simulated microgravity, 14th meeting of the Eur. Cytoskeletal Forum. p 59 1999.
 
Sterin M., Cohen J.S., Mardor Y., Berman E. and Ringel I., Levels of phospholipid metabolites in breast cancer cells treated with anti-mitotic drugs: a 31P magnetic resonance spectroscopy study, 6th Int. Congress on Hormones and Cancer 1999.
 
Mardor Y., Kaplan O., Sterin M., Ruiz-Cabello J., Ash E., Ringel I. and Cohen J.S., Diffusion weighted proton MRS applications to cancer cell metabolism and oncologic pharmacology, 6th Int. Congress on Hormones and Cancer 1999.
 
Ringel I. and Horwitz S.B. An Anti-taxol antibody confirms that taxol binds to b-tubulin in vivo and delineates microtubule bundles in taxol-treated cells, 12th meeting of the Eur. Cytoskeletal Forum. P132, 1997. ​
 
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