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Researchers
  • Dr.  Jacob Golenser
Dr Jacob Golenser
 
Collaborations
 
2005
Kremsner P.G. Institute of Tropical Medicine, Tuebingen Germany, Drug effects on immune functions.
 
Hunt N. University of Sydney, Australia. Cerebral malaria.
 
 
Lab Members  
Yosi Shmulevich, M.Sc. student - Curcumin for treatment of malaria.
 
Avishag Shear, M.Sc. student - Artemisinins against leishmanial parasites.
 
Judith Vaknin, Ph.D. student - Treatment of cerebral malaria.
 
Ora Gaska - Laboratory assistant.
 
 
 
Ongoing Research 
Our studies comprise the design, production and examination of drugs against malaria and leishmaniasis, both of which have global and regional significance. Due to the international interest in these diseases we are cooperating with research groups in both technologically advanced and developing countries. Our specific expertise also involves us in general health projects related to chemotherapy (slow release of drugs, transplantation, cancer, etc.).
 
One of the major problems in the struggle against malaria is the dwindling arsenal of antimalarial drugs due to the evolution of drug resistance. We are thus attempting to define and validate new drug targets, produce derivatives of existing drugs, and use combinations of drugs that might be synergistic or prevent the development of resistance. The current treatment of leishmanial infections is also inadequate due to toxicity of the marketed first line drugs (pentavalent antimonials) and parasite resistance to these drugs.
 
Parasitic infection may be overcome by a variety of balanced immune responses. Drugs may affect the disease by reducing parasite load and by altering immune responses. We are therefore investigating drug effects on both parasites and immune functions.
The variety of techniques which have been used throughout our research with parasites are also applied in experiments concerning the treatment of melanoma, solid tumors and bone infections.
 
 
 
Experience 
1975-1977
Research Associate, University of Nijmegen, The Netherlands.
 
1977-1980
Lecturer, University of Ibadan, Nigeria.
 
1978-1979
Senior Investigator, MRC Durban, South Africa.
 
1979-2005
Senior Investigator in Parasitology, Faculty of Medicine, The Hebrew University of Jerusalem and The Hadassah Medical College, Jerusalem (part time).
 
2005
Visiting Professor, Department of Molecular Pathology, The University of Sydney, Australia.
 
 
 
Education 
1965-1967 
B.Sc. Biology, The Hebrew University of Jerusalem.
 
1968-1970 
M.Sc. Microbiology, The Hebrew University of Jerusalem.
 
1971-1975 
Ph.D. Parasitology, The Hebrew University of Jerusalem.
 
 

Selected Research Support

 
2005
Gretel B. Bloch Trust.
 
Zelman Cowen Trust.
 
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