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Researchers
  • Prof.  Joseph Deutsch
Prof Joseph Deutsch
 
Research Interest

        ·       Mass Spectrometry, Structure elucidation of bioorganic compounds.

        ·       Analysis of lipids and acyl CoAs in rat brain and liver.

        ·       Synthesis of steroids and oligonucleotides.
 
 
Chapters in Books 
D. Lichtstein, T. Levy, J. Deutsch, M. Steinitz. J. S. Zigler, Jr. and P. Russell, Involment of Na /K - ATPase inhibitors in cataract formation. Na /K - ATPase and Related ATPase, 2000 Elsevier ScienceB.V. Ed. E. Taniguchi and S. Kaya.
 
Joseph Deutsch and Thad A. Rosenberger, Analysis of Long and Short-Chain Acyl-Coenzyme A Esters from Mammalian Tissue, (2004), "HPLC of lipids" H.N.B. Publishing in New York City. Ed. Jiann-Tsyh (Ken) Lin and Dr. Thomas A. McKeon.
 
 
Abstracts 
Tal Peleg-Shulman, Joseph Deutsch and Dan Gibson, Mass spectral studies of the interaction of anticancer platinum drugs with biopolymers, Proceeding of the Annual Meeting of the Israeli Soc. for Mass Spectrometry, Haifa, Israel 2001.
 
R.A. Velliquette, J. Deutsch, P. Ernsberger, Altered fatty acid activation in obesity: Depletion of hepatic linoleoyl-CoA in SHROB rats lacking in leptin receptor gene, Proceeding of the Experimental Biology 2001, Orlando, FL.
 
Aneta E. Reszko, Tahir Kasumov, Blandine Comte, Bradley Pierce, France David, Joseph Deutsch, Christine Des Rosiers, and Henri Brunengraber, Measurement of the kinetics of malonyl-CoA in tissues, Proceeding of the Experimental Biology 2001, Orlando, FL.
 
J. Deutsch, G.Ben-Menahem S. Rotem, U. Zahringer, F. Wagner and E.Th. Ritschel, Mass spectral evidence for a linear structure of the phosphocholine glycerolipid found in Mycoplasma Fermentans, Proceeding of the Annual Meeting of the Israeli Soc. for Mass Spectrometry, 1998 Jerusalem, Israel.
 
Lichtstein D., Steinitz M., Gati I., Samuelov S., Levi T., Shpolansky U., Deutsch J.and Orly J., Bufodienolides as endogenous Na , K -ATPase inhibitors: Biosynthesis in rat adrenal cells, Am. J. Hyperten. 10, 273 1997.
 
R.A. Velliquette, J. Deutsch, P. Ernsberger, Imidazoline agonists increase Hepatic arachidonoyl-CoA on injection into portal vein, Proceeding of the Experimental Biology 2001, Orlando, FL.
 
J. Deutsch, E. Shohami, H. Heller, B. Kalderon, S.I. Rapoport and D. Purdon, ESI/MS of long chain acyl carnitines in acclimated rat brain after cerebral trauma, Proceeding of the Annual Meeting of the Israeli Soc. for Mass Spectrometry, 1999 Jerusalem, Israel.
 
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Publications 
J. Deutsch+, B. Kalderon, A.D. Purdon and S.I Rapoport, Evaluation of Rat Brain Long Chain Acylcarnitines During Cerebral Ischemia. Lipids, 35, 693-696 (2000).
 
D. Lichtstein, T. Levy, J. Deutsch, M. Steinitz. J. S. Zigler, Jr. and P. Russell, Involment of Na+/K+- ATPase inhibitors in cataract formation. Na+/K+- ATPase and Related ATPase, 2000 Elsevier ScienceB.V. Ed. E. Taniguchi and S. Kaya.
 
Greig,-N-H; De-Micheli,-E; Holloway,-H-W; Yu,-Q-S; Utsuki,-T; Perry,-T-A; Brossi,-A; Ingram,-D-K; Deutsch,-J; Lahiri,-D-K; Soncrant,-T-T. The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics. Acta-Neurol-Scand-Suppl. 2000; 17674-84
 
A E. Reszko, T. Kasumov, B. Comte, B. A. Pierce, F.David, Ilya R. Bederman, Joseph Deutsch, Christine Des Rosiers, and Henri Brunengraber. Assay of the Concentration and 13C-Isotopic Enrichment of Malonyl-Coenzyme A by Gas Chromatography-Mass Spectrometry, Analytical Biochemistry, 298, 69-75 (2001).
 
Joseph Deutsch, Stanley I. Rapoport and Thad A. Rosenberger, Coenzyme A and short-chain acyl-CoA species in control and ischemic rat brain, Neurochemical Research, 27, 1577-1582 (2002).
 
Joseph Deutsch, Stanley I. Rapoport and Thad A. Rosenberger, Valproyl-CoA and esterified valproic acid are not found in brains of treated with valproic acid, but the concentration of CoA and acetyl -CoA are altered Neurochemical Research, 28, 861-865 (2003).
 
I. Katzir, J. Shani, G. Goshen, J. Sela, E. Ninary, A. M. Dogonovski, D. Shabashov, S. Inoue, K. Ikeda, K. Hayashi, J. S. Gorinstein, J. Deutsch and P. Lazarovici. Characterization of Nerve Growth Factors (NGFs) from snake venoms by use of a novel, quantitative bioassay utilizing PC12 cells over-expressing human TRKA receptors. (2003) Toxicon 42, 481-490.
 
O. Ilovich and J. Deutsch, A Selective Synthesis of Bromofuran Derivatives, (2005) Heterocycles, 42, 1409-1411.
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D. Maoz 1, Ho-Joo Lee, J. Deutsch, S. I. Rapoport and R.P. Bazinet, Immediate no-flow Ischemia Decreases rat Heart Non-esterified Fatty acid and Increases Acyl-CoA Species Concentrations. (2005) Lipids, 40, 1149-1154.
 
Joseph Deutsch, Huang G. Jang, Nura Mansur, Ohad Ilovich, Uri Shpolansky, Dana Galili, Tomer Feldman, Haim Rosen and David Lichtstein, 4-(3'a15'b-Dihydroxy-5'b-estran-17'b-yl)furan-2-methyl alcohol, An Anti-Digoxin Agent with a Novel Mechanism of Action.(2006) J. Med. Chem., 49, 600-606.
 
J. Deutsch, Ma Kaizong and S. I. Rapoport, An accelerated mass spectrometric method for measuring myo-inositol in phosphatidylinositol in rat brain. (2006) Int. J. of Mass Spectrom. 249-250, 392-395.
 
Ma, Kaizong; Deutsch, Joseph; Villacreses, Nelly E.; Rosenberger, Thad A.; Rapoport, Stanley I.; Shetty, H. Umesha. Measuring brain uptake and incorporation into brain phosphatidylinositol of plasma myo-[2H6] inositol in unanesthetized rats: An approach to estimate in vivo brain phosphatidylinositol turnover. (2006), Neurochemical Research 31(6), 759-765.
 
Warburg, A., Gelman S. & Deutsch J. (2007). Xanthine in urine stimulates growth of Leishmania promastigotes in vitro. J. Med. Microbiol. 57,136-138 
 
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