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Researchers
  • Prof.  Meir Bialer
Prof.  Meir Bialer
 
Research Projects 

        ·       Pharmacokinetics and biopharmaceutics of existing and new drugs.

        ·       Pharmacokinetics-based design of new antiepileptics and CNS drugs.

        ·       Structure – pharmacokinetic-pharmacodynamic relationship (SPPR).

        ·       Pharmacokinetic evaluation of drug interactions, new drug delivery systems, prodrugs and controlled-release formulations.

        ·       Stereospecific pharmacokinetic and pharmacodynamic analysis of chiral drugs.

        ·       Pharmacokinetic and metabolic analysis of new CNS drugs at induced and non induced conditions.

  

Collaborations  
NIH Epilepsy Branch.
 
Prof. Rene H. Levy, Univ. of Washington, Seattle, USA.
 
Prof. H. Steve White, Univ of Utah, USA.
 
Prof Emilio Perucca, Univ. of Pavia, Italy.
 
Luigi Specio, Univ. of Pavia, Italy.
 
Prof. Richard Finell, Texas A&M Univ., USA.
 
Prof. Boris Yagen, The Hebrew Unievraity of Jerusalem.
 
Marshal Devor, The Hebrew University of Jerusalem.
 
Adrian Harwood, Univ. of Cardiff, UK.
 
Prof. Stefan Sovack.
 
Prof. Yoseph Caraco, Hadassah University Hospital, Jerusalem.
 
 
 
Patents 
Meir Bialer, Salim Hadad, Yaacov Herzig, Jeff Sterling, David Lerner, Mitch Shirvan. Derivatives of valproic acid amide and 2-valproenoic acid amide, method of making and use thereof as anticonvulsant.
        -U.S. Patent No. 5,585,358. Issued 17 December, 1996.
        -IL Pat No. 110216 issued 21/10/1994
        -IL Pat No. 133891 (divisional pat)  issued 13/05/2003
        -EP Pat No. 0659174 issued 10/02/1999 valid in CH,DE,FR,ES,GB
        -NZ Pat No. 269643 issued 17/04/1997
        -Jp Pat No. 3856464 issued 22/09/2006
        -CA Pat No. 2,143,636, issued 01/05/2007
        -AU Pat No. 673766 issued 12/03/1997
        -Chinese Pat No. ZL94190471.7 issued 23/04/2003
        -Chinese Pat (DIV) No. ZL02105358.8 issued 04/02/2009
 
Meir Bialer, Arie Dagan, Sherbel Sussan. Anticonvulsant drugs and pharmaceutical compositions thereof.
        -U.S. Patent No. 6,028,102 (Issued: 22 February, 2000).
        -IL Patent Application No. 137740.
 
Meir Bialer, Boris Yagen, Niv Papo. Active derivative of valproic acid for the treatment of neurological and psychotic disorders and a method for their preparation.
        -U.S. Patent No. 6,323,365 (Issued: 27 November, 2001). 
        -European Patent No. 1176138, issued 01/12/2004, valid in GB, DE, FR, IT, SP and CH
        -IL Patent No. 130666, issued 15/12/2002
 
Jeff Sterling, Yaacov Herzig, Meir Bialer, Abdullah Haj-Yehia, Boris Yagen. Derivatives of tetramethylcyclopropane.
        -U.S. Patent No. 5,880,157 (Issued: 9 March, 1999).
        -German Patent No. 19518497.5 (Issued: 5 August, 2004).
        -IL Pat No. 108595, issued 27/12/1998
 
Meir Bialer, Boris Yagen, Ofer Spiegelstein, Michael Roeder and Volker Schurig. Amelioration of neurological disorders by the administration of (2R),(3S) and/or (2S),(3S) stereoisomers of valnoctamide.
        -U.S. Patent No. 6,417,399 (Issued: 9 July, 2002).
        -European  Patent No. 98900346.2  validated  in Germany, France,  England, Spain,  Italy, Switzerland,  Greece,  Belgium, Netherlands
         and Sweden.
        -IL Patent No. 120006 (Issued: 7 March 1999).
 
Meir Bialer, Ofer Spiegelstein, Boris Yagen. Propylisopropyl acetic acid and propylisopropyl acetamide stereoisomers, a method for their synthesis and pharmaceutical compositions containing them.
        -U.S. Patent No. 6,630,602, issued 07/10/2003
        -European Patent No. 1077926, issued 23/02/2005, valid in GB, FR, DE, CH
        -IL Patent No. 124118 (stereoisomers) issued 21/12/2007
        -IL Patent  No.136030  issued 12/05/2007 (racemic mixtures).
        -US Pat No. 6,969,732, issued 29/11/2005.
 
Amnon Sintov, Andrew Volosov, Meir Bialer, Boris Yagen. Pharmaceutical compositions containing low-melting waxes.
        -U.S. Patent Application Serial No. 09/743,260 (Filing date: 8 January, 2001).
        -European Patent application No. 99928200.7
        -IL Patent Application No. 125244.
 
Meir Bialer, Nina Isoherranen, Boris Yagen. Derivatives of valproyl taurinamide, method of making and use thereof as anticonvulsant and CNS active agents.
        -US Pat No.  6,958,416 issued 25/10/2005
 
Meir Bialer, Nina Isoherranen, Boris Yagen. Derivatives and pharmaceutical compositions of N-Hydroxymethyl Tetramethylcyclopropyl-Carboxamide having anti-epileptic, neurological and CNS activity, and method for their preparation.
        -IL Patent No. 147953 issued 13/04/2008
        -International Application No. PCT/IL02/0150 (International filing date: 29 December, 2002)
        -US pat No. 6,960,687 issued 01/11/2005
 
Meir Bialer, Boris Yagen, Dan Kaufmann, and Eyal Sobol. New Amide derivatives of 2,2,3,3-tetramethylcyclopropane carboxylic acid, a method their synthesis and pharmaceutical compositions containing them.
        -IL Patent Application No. 154694 (Filing date: 28/02/2003),  and IL Patent Application No.157751 (Filing date: 4/09/2003).
        -International Application No. PCT/IL04/000193. (Filing date: 26 February, 2004).
        -EP pat no. 1603891, issued 28/05/2008  valid in DE, GB, CH & FR
 
Meir Bialer, Boris Yagen, Haim Pinchas Belmaker, Galila Agam, Galit Shaltiel. Use of 2,2,3,3, tetramethylcyclopropane carboxylic acid derivatives for treating psychiatric disorders.
        -EP pat No. 1626710, issued 01/10/2008 valid in GB, FR, DE and Switzerland.
        -Pending patent applications in : US, IL, CA & JP
 
Meir Bialer, Boris Yagen, Sara Eyal, Yoram Altschuler. Topiramate compositions useful for the treatment of cancer.
        -IL Patent Application No.156888 (Filing Date: 29 June 2003).
 
Meir Bialer, Boris Yagen , Ilan Winkler,  Marshal Devor. Compounds useful for treating neurological disorders.
        -Pending patent applications in Israel, Europe and US
 
Meir Bialer, Boris Yagen , Sara Eyal. Use of valproyl hydroxamic acid as an antineoplastic agent.
        -IL Patent Application No. 162263 (Filing Date: 31 May 2004)
 
Meir Bialer, Mitchell Shirvan. Use of Derivatives of Valproic Acid and 2-Valproenic Acid Amides for the Treatment of Mania Bipolar Disorder.
        -US Pat No. 6,555,585, issued 29/04/2003
        -NZ Pat No. 532917, issued 03/10/2005
        -Korean Pat No. 10-0843703, issued 27/06/2008
        -MX Patent No. 233952, issued 25/01/2006
         Pending paten applications in Canada, China, Europe, Isral, Japan , Australia.
 
Meir Bialer, Mitchell Shirvan. Use of Derivatives of Valproic Acid Amides and 2-Valproenoic Acid Amides for the Treatment of Pain and /Or Headaches Disorders
        -EP Pat No. 1311256, issued 17/08/2005 valid in FR,UK,EI,IT,NL,BE,CH,DE,ES
        -Chinese Pat No. 01817134.6, issued 18/02/2009
        -Korean Pat No. 10-0851955, issued 06/08/2008
        -South African pat No. 2003/1427, issued 28/04/2004
        -MX Pat No. 239154, issued 02/08/2006
         Pending patent applications in US, JP, AU, and IL
 
 
Meir Bialer, Boris Yagen , Neta Pessah . New -halo and -alkyl CNS-Active Analogues of Valproic Acid.
         Pending Patent applications in US and Israel , from PCT WO 008/102348 filed 19/02/08
 
Meir Bialer, Boris Yagen, Shimshoni Jakob Avi. ACYL-UREA DERIVATIVES AND USES THEREOF PCT app PCT/IL2008/000870,  WO 2009/001356 filed 25/06/2008
 
 
 
Recent Publications
 
M. Bialer. Chemical properties of antiepileptic drugs (AEDs). Adv. Drug Deliv. Rev. 64: 887-895 (2012)
 
I. Bejarano-Achache, L. Levy, L. Mlynarsky, M. Bialer, M. Muszkat, Y. Caraco. The impact of CYP4F2 genetic polymorphism on warfarin responsiveness during initiation phase. A prospective, open-label, observational, cohort study. Clin. Ther. 34: 811-823 (2012).
 
N. Hen, M. Bialer, B. Yagen. Syntheses and evaluation of anticonvulsant activity of novel branched alkyl carbamates. J. Med. Chem. 55:2835-2845 (2012).
 
M. Bialer, P. Soares-da-Silva. Pharmacokinetics and drug interactions of eslicarbazepine acetate. Epilepsia.53: 935-946 (2012).
 
M . Bialer. Comments on the working group's 2012 review of the NIH-ASP program, Epilepsia, in press.
 
M. Bialer. Why are antiepileptic drugs (AEDs) effecting in treatment non-epileptic conditions? Epilepsia, in press.
 
M. Bialer. How Phenobarbital chemical Structure Affected the Development of Subsequent Antiepileptic Drugs (AEDs)?  Epilepsia, in press.
 
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