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Researchers
  • Prof.  Menachem Hanani
Menachem Hanani
 
Research Interests  
  
 
Basic mechanisms of chronic pain. We study how nerve damage and inflammation change the morphology and physiology of nerve and glial cells. We obtained evidence that such changes contribute to chronic pain, and how reversing them can serve for pain therapy. We use electrophysiology and various imaging techniques (e.g., calcium imaging) to study glia-glia and neuron–glia interactions.
Gap junctions in sensory and autonomic ganglia.
The contribution of the sympathetic nervous system to pain, with emphasis on satellite glial cells.
Physiology of the autonomic nervous system in animals and humans.
The intrinsic nerves of the human digestive tract in health and disease.
The effects of natural products on the nervous system and on smooth muscle cells.
Glial cells in the peripheral nervous system.
Physiology of fat tissue.
 
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 Recent Projects
 
The role neuron-glia and glia-glia interactions in sensory ganglia in chronic pain.
 
Augmentation in gap junction-mediated cell coupling in dorsal root ganglia following sciatic nerve neuritis in the mouse.
 
Mechanisms of visceral pain. 
 
Phenotypic changes in satellite glial cells in cultured trigeminal ganglia.
 
Differential effect of hyperthermia on nerves and smooth muscle of the mouse  ileum.
 
Functional study of endothelin B receptors in satellite glial cells in trigeminal ganglia. 
 
Upregulation of purinergic P2X receptor expression after peripheral inflammation in satellite glial cells of mouse trigeminal ganglia: A calcium imaging study.
 
Morphological study of the myenteric plexus in the human tenia coli. 
 
The contribution of satellite glial cells to chemotherapy-induced neuropathic pain.
 
Non-adrenergic innervation of fat cells.
 
Gap junctions in fat tissue.
 
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Lab Members 
Menachem Hanani, Ph.D.
 
Ahmed Eid, M.D.
 
Shoshana Burk, M.D.
 
Rachel Goriachnik-Feldman, Ph.D. Student
 
Vitali Belzer, Ph.D. Student
 
Rebekah Warwick, Ph.D. Student
 
Erez Blum, Ph.D. Student
 
 
Selected publications
 
Huang TY,  Belzer V,  Hanani M. Gap junctions in dorsal root ganglia: possible contribution to visceral pain. Europ J Pain 14:49-57, 2010. 
 
Suadicani, S.O.,  Cherkas, P.S.,  Zuckerman, J., Smith, D.N., Spray, D.C., Hanani, M. Bidirectional calcium signaling between satellite glial cells and neurons in cultured mouse trigeminal ganglia. Neuron Glia Biology  6:43-51, 2010.
 
Hanani, M. Satellite Glial Cells in Sympathetic and Parasympathetic Ganglia: In Search of Function. Brain Res Rev  64:304-327, 2010 
 
Hanstein, R.,  Basak, R.,  Zhao, J.B.,  Smith, D.N.,  Zuckerman, Y., Hanani, M., Spray, D.C.,  Gulinello, M. Transient focal inflammation causes carbenoxolone-sensitive chronic pain in mice. Open Pain Journal 3:122-133, 2010.
 
Belzer, V., Shraer, N., Hanani, M.  Phenotypic changes in satellite glial cells in cultured trigeminal ganglia. Neuron Glia Biology, 6, 237-243, 2011.
 
Burke, S., Abu-Wasel, B., Eid, A.,  Nissan, A., Hanani, M.  Differential effect of hyperthermia on nerves and smooth muscle of the mouse  ileum. J Surg Oncol 103:92-100, 2011.
 
Feldman-Goriachnik, R., Hanani, M. Functional study of endothelin B receptors in satellite glial cells in trigeminal ganglia. NeuroReport,  22:465-469, 2011.
 
Kushnir, R., Cherkas, P.S., Hanani, M. Peripheral inflammation upregulates P2X receptor expression in satellite glial cells of mouse trigeminal ganglia: A calcium imaging study. Neuropharmacology, 61:739-746, 2011.
 
Hanani M. Lucifer yellow – an angel rather than the Devil.  J. Cell. Mol. Med. 16, 22-31, 2012.
 
Burke, S., Hanani, M. The actions of hyperthermia on the autonomic nervous system: central and peripheral mechanisms and clinical implications. Autonomic Neurosci. 168:4-13, 2012.
 
Hanani, M.,  Grossman, S., Nissan, A.,  Eid, A. Morphological and quantitative study of the myenteric plexus in the human tenia coli. Anat. Rec. 295:1321-1326, 2012.
 
Hanani, M. Intercellular communication in sensory ganglia by purinergic receptors and  gap junctions: Implications for chronic pain. Brain Res.  1487:183-191, 2012.
 
Hanani,  M., Spray, D.C. Glial Cells in autonomic and sensory ganglia. In: Neuroglia; H. Kettenmann and B.R. Ransom, Eds. Oxford Univeresity Press, 2013.  
 
Warwick, R.A., Hanani, M. The contribution of satellite glial cells to chemotherapy-induced neuropathic pain. Europ. J. Pain. In press.
 
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