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  • Prof.  Michal Horowitz
Prof Michal Horowitz
Born 1939, Afula, Israel

Ph.D. 1971, Hebrew Univ.

Lect. 1976

Sen. Lect. 1978

Assoc. Prof. 1985

Prof. 1990
Field of study 
Our studies focus on mechanisms associated with the dynamics of heat acclimation. Within this frame we study the linkage between global genomic/proteomic responses and integrative physiological adaptive mechanisms. Our current research focuses on:
         ·       Heat acclimatory responses in the heart and the hypothalamus
         ·       Beneficial effects of heat acclimation  on  non-thermoregulatory-associated  protective  effects, namely, on  the  phenomenon  that
                  adjusting  to  one  environmental  stressor  can,  in  addition  to  the  evolving  of  the  primary  adaptations,  add  to the  amount  of
                  adjustment to novel stressors without prior exposure to it (exaptation). 
An important beneficial effect of heat acclimation observed in our laboratory is the development of “cross-tolerance” against oxygen supply/oxygen demand mismatching and its consequences in the heart. In this respect, we study:

        ·       Sarcoplasmic reticulum calcium regulatory proteins and cardiomyocytes calcium homeostasis;

        ·       HSP in heat acclimation and cross-tolerance;

        ·       The role played by thyroid hormone status in heat acclimation;

        ·       The role played by HIF 1α in heat acclimation and its contribution to heat-acclimation-oxygen deprivation cross-tolerance.


Laboratory Techniques


Integrative physiological responses: online recordings of rectal, skin and hypothalamic temperatures, as well as systemic blood pressure and heart rate

Cardiac Performance: Studies on isolated perfused heart and isolated cardio-myocytes using fluorimetric and imaging systems for ion measurements and contractile responses.

Global genomic responses and protein maps: microarray technology, 2D gels, immunohistochemistry, confocal microscopy and various molecular and biochemical techniques. 




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