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  • Prof.  Millet Treinin
Prof Millet Treinin
Research Interests 
Identification and characterization of molecular mechanisms underlying neuronal function and dysfunction.
Recent Projects 
     Mechanisms regulating functions of RIC-3, a key player in Nicotinic Acetylcholine receptor maturation.
     Function and dysfunction of Nicotinic Acetylcholine Receptors.
     Molecular determinants of nociceptor function. 
     Mechanisms underlying enduring behavioral responses to noxious stimuli. 
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Laboratory Techniques 
Genetics, molecular biology, electrophysiology.
Lab Members 
Emil Battat
Yael Ben-David
Emiliano Cohen
Gracia Safdie
Ithai Rabinowitch, PhD
Tal Zinger 
 Recent Publications
Millet Treinin. RIC-3 and Nicotinic Acetylcholine Receptors: Biogenesis, Properties, and Diversity. Biotechnology Journal.  3, 1539-1547(2008).
Anna Shteingause, Emiliano Cohen, Yoav Biala, and Millet Treinin. The BTB/MATH protein BATH-42 interacts with RIC-3 to regulate nicotinic acetylcholine receptor maturation.  Journal of Cell Science 122, 807-812 (2009).
Yoav Biala, Jana F. Liewald, Hagit Cohen Ben-Ami, Alexander Gottschalk, and Millet Treinin. The conserved RIC-3 coiled-coil domain mediates receptor specific interactions with Nicotinic Acetylcholine Receptors.  Molecular and Cellular Biology 20, 1419-1427 (2009).
Hagit Cohen Ben-Ami, Yoav  Biala, Hanna Farah,  Esty Elishevitz, Emil Battat,  and Millet Treinin. Receptor and subunit specific interactions of RIC-3 with Nicotinic Acetylcholine Receptors. Biochemistry 48, 12329-12336 (2009).
Meital Oren-Suissa, David H. Hall, Millet Treinin, Gidi Shemer and Benjamin Podbilewicz.  The fusogen EFF-1 controls sculpting of mechanosensory dendrites. Science. 328,1285-1288 (2010).
Marios Chatzigeorgiou, Wei Hsiang Lee, Joseph D. Watson, Sungjae Yoo, W. Clay Spencer, Katie S. Kindt, Sun Wook Hwang, David M. Miller, III, Millet Treinin, Monica Driscoll, William R. Schafer. Specific roles for DEG/ENaC and TRP channels in mechanical and thermal sensation in C. elegans polymodal nociceptors. Nature Neuroscience 13, 861-8 (2010).
Cody J. Smith, Joseph D. Watson, W. Clay Spencer, Tim O’Brien, Byeong Cha, Adi Albeg, Millet Treinin, David M. Miller. Time-lapse imaging and cell-specific expression profiling identify dynamic processes and molecular determinants of a multi-dendritic nociceptor in C. elegans. Developmental Biology. 345, 18-33 (2010).
Adi Albeg, Cody Smith, Marios Chatzigeorgiou, Dror G. Feitelson, David H. Hall, William R. Schafer, David M. Miller, and Millet Treinin. . C. elegans multi-dendritic sensory neurons: morphology and function. Molecular and Cellular Neuroscience, 46, 308-317 (2011).
David H. Hall and Millet Treinin. How does morphology relate to function in sensory arbors? Trends in Neuroscience 34, 443-451 (2011).
Steven J. Husson, Wagner Steuer Costa1, Sebastian Wabnig, Jeffrey N. Stirman, Joseph D. Watson, W. Clay Spencer, Jasper Akerboom, Loren L. Looger, Millet Treinin, David M. Miller, III, Hang Lu, and Alexander Gottschalk. Optogenetic analysis of a nociceptor neuron and network reveals modulatory ion channels acting downstream of nociceptive sensors. Current Biology, 22, 743-752 (2012).
Emiliano Cohen, Eviatar Yemini, Dror G. Feitelson, William R. Schafer, and Millet Treinin. Locomotion analysis identifies roles of mechanosensory neurons in governing locomotion dynamics of C. elegans. Journal of Experimental Biology, 215, 3639-3648. 
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