Past research projects have focused on the mechanism of food-induced hemolytic crisis in G-6-PD deficiency (Favism), and the role of transition metals in injurious processes in biology and medicine involving free radicals—which are either spontaneous (e.g. aging or ischemic heart disease) or induced by drugs, foods, xenobiotics or radiation. He has also investigated the effects of burn injury to skin and eye tissues by toxic chemicals including warfare agents. Recently he focused on novel mechanisms of protection of the ischemic heart, brain and retina. These studies have been extended to the diabetic heart.
• Mechanisms of injury and modes of protection of the diabetic heart under ischemia.
• Mechanism of injury and modes of protection of ischemic retinal injury and age related macular degeneration.
• The development of novel modalities for the treatment of oxidative stress and inflammation relating to asthma and skin disorders.
• Eduard Berenshtein, M.D., Ph.D.
• Roslana Alper, Ph.D.
• Vladimir Vinokur, Ph.D.
• Hilbert Grievink, Ph.D.
• Mara Shapero, visiting research assistant
• Professor Abraham M. Konijn, Co-Investigator
• Professor Benjamin Drenger, Co-Investigator
M. Chevion, S. Leibowitz, N.N. Aye, O. Novogrodsky, A. Singer, O. Avizemer, et al: Heart protection by ischemic preconditioning: A novel pathway initiated by iron and mediated by ferritin. J Mol Cell Cardiol. 45: 839–845, 2008.
B.E. Bulvik, E. Berenshtein and E.G. Meyron-Holtz: “Cardiac Protection by Preconditioning is Generated via an Iron-Signal Created by Proteasomal degradation of Iron Proteins”. PLos ONE 7(11): e48947. Doi:10.1371/journal.phone.0048947, 2012.
A. Obolensky, E. Berenshtein, A.M. Konijn, E. Banin and M. Chevion: Ischemic preconditioning of the rat retina: Protective role of ferritin. Free Radic Biol Med. 44(7):1286-1294, 2008.
E. Deleon, M. Lederman, E. Berenstein, T. Meir, M. Chevion and I.Chowers: Alteration in Iron Metabolism During Retinal Degeneration in rd10 Mouse. Invest Ophthalmol Vis Sci. 50(3):1360-5, 2009.
A. Obolensky, E. Berenshtein, M. Lederman, B. Bulvik, R. Alper-Pinus, R. Yaul, E. Deleon, I. Chowers, M. Chevion and E. Banin: Zinc-desferrioxamine attenuates retinal degeneration in the rd10 mouse model of retinitis pigmentosa. Free Radic. Biol. Med. 51(8):1482-91, 2011.
V. Vinokur, S. Weksler-Zangen, E. Berenshtein, R. Eliashar and M. Chevion: Heredity or Nutrition in the Diabetic Heart: Roles of Iron in Protection by Preconditioning. Submitted for publication.
V. Vinokur, E. Berenshtein, B. Bulvik, L. Grinberg, R. Eliashar and M. Chevion: The bitter fate of the sweet heart: iron homeostasis impairment leads to failure in diabetic heart cardioprotection. Submitted for publication