The development of an organism from a mass of undifferentiated cells into a fully functioning adult is one of the most fascinating and complex processes in all of nature. Research in our lab is directed toward understanding how complementary and sometimes antagonistic processes such as proliferation promotion and arrest, programmed cell death, cell-fate specification and pattern formation are regulated and coordinated during organ formation. The deregulation of proliferation and programmed cell death underlies human pathologies like cancer, autoimmunity, hyper-inflammatory states, and neurodegenerative disease, whereas the failure to control differentiation, or establish proper morphological connections, result in many pathological situations including genetic malformation syndromes.
We take advantage of the powerful genetic and molecular techniques available in Drosophila, which facilitate both gene discovery and the analysis of gene function, to study the cellular and molecular mechanisms, which govern these processes.
Ziv O, Finkelstein R, Suissa Y, Dinur T, Deshpande G and Gerlitz O “Inverse Regulation of Target Genes at the Brink of the BMP Morphogen Activity Gradient” (J Cell Sci. 2012)
Mollereau B, Perez-Garijo A, Bergmann A, Miura M, Gerlitz O, Ryoo H D, Steller H and Morata G “Compensatory proliferation and apoptosis-induced proliferation: a need for clarification”. Cell Death Differ. 2013 Jan;20(1):181.
Neuman H, Suissa Y, Ziv O, Ordan E, Weisman I, Grossman J, Dinur T and Gerlitz O “A screen identifying genes responsive to Dpp and Wg signaling in the Drosophila developing wing”. GENE 2012; 15;494(1):65-72
Suissa Y, Ziv O, Dinur T, Arama E and Gerlitz O “The NAB-BRK Signal Bifurcates at JNK to Independently Induce Apoptosis and Compensatory Proliferation”. J Biol Chem 2011; 286(17):15556-64
Suissa Y, Ordan E, Deshpande G and Gerlitz O “Males and Females: Creating Differences while Maintaining the Similarities”. Fly; 2011; 5(1):25-8
Yekhtina Z, Hirshfeld E, Weiss L, Gerlitz O, Slavin S and Shapira MY “Multidonor bone marrow transplantation improves donor engraftment and increases the graft vs. tumor effect while decreasing graft vs. host disease”. Transplant International 2011; 24(2):194-200
Lavon I, Zriha D, Granit A, Einstein O, Fainstein O, Cohen ME, Cohen MA, Zelikovitch B, Shoshan Y, Spektor S, Reubinoff BE, Felig Y, Gerlitz O, Ben-Hur T, Smith Y, Siegal T “Gliomas Display a microRNA Expression Profile Reminiscent of Neural-Precursor-Cells”. Neuro-Oncology 2010; 12:422-33
Suissa Y, Kalifa Y, Dinur T, Graham P, Deshpande G, Schedl P and Gerlitz O “Hrp48 Attenuates Sxl Expression to Allow for Proper Notch Expression and Signaling in Wing Development”. Proc Natl Acad Sci 2010; 107(15):6930-5