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Researchers
  • Prof.  Philip Lazarovici
Prof.  Philip Lazarovici
 
Scientific Interest
 
Lazarovici Philip, a member of the Institute of Drug Research of the School of Pharmacy. An acclaimed neuropharmacologist, Professor Lazarovici graduated in pharmacology and toxicology at the Hebrew University, post graduated on neurobiology at the Weizmann Institute of Science and conducted neurochemical and molecular research at the National Institutes of Child Health and Human Development, NIH as a visiting scientist, which all set the stage for his lifelong career on neuropharmacology. His groundbreaking work provided Israeli scientific community with pharmacological neuronal models towards development of different brain neuroprotective drugs and elucidation of their mechanism of action. Prof. Lazarovici is a member of 15 international and national academic societies published 200 scientific articles and reviews and edited six books in his field of research. He is most proud of his graduate students which are active in the Israeli community pharmaceutical practice, academia, hospitals and institutions of teaching and research.
 
The research interests and activities of the laboratory of Neuropharmacology, Neurooncology and Neural Engineering (LNNN) headed by Prof. Lazarovici lie in the fields of neuropharmacology, neurotoxicity, neural engineering and neurooncology with emphasize on neurotrophins and neurotoxins signal transduction and receptor regulation. 
 
     Receptors: structure, regulation and signal transduction.
 
     NGF-trkA receptors: tissue distribution, function, regulation, drug discovery.
 
     Toxins-pharmacological tools to understand molecular function and lead compounds for drug discovery.
 
     Neuronal pharmacological models to study neurological diseases: pathological mechanisms and therapeutic approaches.
 
     Cell therapy using cord blood stem cells.
 
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Research Projects  
 
Isolation, characterization and mechanism of action of a novel and selective pharmacological antagonist (VP12) from Vipera palestinae venom targeting α2β1 collagen binding receptor (GIF).
 
Development of stable, safe and potent anti-metastatic lead compound, using disintegrin-antagonist(s) highly selective for α1 integrin receptor (NOFAR).
 Vipegitide, an α2 integrin receptor peptidomimetic antagonist with anti-adhesive and anti-coagulant properties (KAMIN).
 
Characterization of PLX Using Molecular and Cellular Neuroprotective Assays for Generation of Quality Control Platform (MAGNETON).
 
Ultrasound Assisted, Enhanced Topical Delivery of Methotrexate (MTX) from a Lipid Vesicular Carrier for Arthritis Therapy (HUJI-Drexel Cooperation).
 
Molecular characterization of nerve growth factor (NGF) angiogenic effect in endothelial cells using snake venom NGF-agonists (Bloom Research Center).
 
Development of a near infrared bio-imaging technology using epidermal growth factor and antibodies for visualization of colorectal cancer (MAGNET).
 
Tissue engineering approaches on stem cells from human placenta and cord blood for therapy of brain trauma (Ministry of Science, Technology and Space).
 
 
Lab Members
Dr. Tatjana Momic, Post Doc
 
Dr. Keren Ettinger, Post Doc
 
Mr. Gadi Cohen, PhD student (Final stage)
 
Miss. Galit Gincberg, PhD student (Shlav B)
 
Miss. Adi Lahiani, PhD student (Shlav A)
 
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Industry
Teva Co., Netanya, Israel.
Pluristem Therapeutics Inc. Haifa, Israel.
CollPlant Ltd. Ness-Ziona, Israel.
Given Imaging, Ltd. Yoqneam, Israel.
BiolineRX, Jerusalem, Israel.
Alomone Labs.Ltd., Jerusalem, Israel.
  
Collaborations
 
Prof. Lelkes Peter – the Laura H. Carnell Professor and Founding Chair of the Department of Bioengineering in the College of Engineering at Temple University – Tissue engineering and cardiovascular pharmacology.
 
Prof. Marcinkiewicz Cezary - Department of Neuroscience, Temple University, Philadelphia, USA - Snake Venom Disintegrins and C-lectin type proteins.
 
Prof. Peter Lewin - School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, USA –Ultrasound induced drug delivery.
 
Prof. Michael Chopp - Department of Neurology, Henry Ford Health System, Detroit, USA - Brain Stroke.
 
Prof. Eiden Lee - Section on Molecular Neuroscience, NIH, Bethesda, USA - PC12/NGF.
 
Prof. Lester David - Global Research and Development. Pfizer Inc. New-York. USA - Drug discovery/novel clinical technologies.
 
Prof. Levy Andrea - Institute of Neurobiology, Rome, Italy – NGF.
 
Prof. Bernardini Renato - Department of Clinical Pharmacology, Faculty of Medicine, Catania, Sicily, Italy - Angiogenesis/NGF.
 
Prof. Dr. Johannes A. Eble - Excellence Cluster Cardio-Pulmonary System Center for Molecular Medicine Vascular Matrix Biology Frankfurt University Hospital, Frankfurt, Germany - Collagen integrin receptor.
 
Prof. Nikos Tsopanoglou – Department of Pharmacology, Medical School, University of Patras, Patras-Rio, Greece - Angiogenesis.
 
Dr. Donald W. Fink, CBER, FDA, Rockville, MD, USA - Cell therapy.
 
 
 
Laboratory Techniques
Biochemical: protein purification, chromatography, FPLC, HPLC, electrophoresis, amino acid analysis, sequencing, ultracentrifugation, circular dichroism, Raman spectroscopy, fluorescence, radioactive labeling, pulse chase, DNA/RNA isolation and  labeling, autoradiography, phospholipids and glycolipid analysis, TLC, gas chromatography, peptide synthesis, solid phase technology, etc.
 
Molecular: western blotting, northern, southern, immunoprecipitation, RT-PCR, cloning, gene expression, overexpression, dominant negative, site-directed mutagenesis, transfection, protein and DNA microarrays, drug discovery.
  
Cellular: tissue culture, light microscopy, confocal microscopy, immunohistochemistry, SEM, TEM, transport, exocytosis, neurotransmitter release, proliferation, differentiation, apoptosis, toxicity, angiogenesis, bioassay, oxygen glucose deprivation (OGD), radioreceptor assay, signal  transduction assays, cell labeling mutagenesis, selection, cloning, sorting, FACS, IMACS, disease models, drug discovery and development.
 
Tissues: dissection, histology, pharmacological organs preparations (guinea pig ileum, trachea, aortic rings, uterus, heart, brain slices, synaptosomes, neuromuscular preparation, etc.), toxicity, pharmacology, tissue engineering, scaffolds.
 
Animals: in vivo experiments, small animals surgery, dissection, pharmacological models, transgenic, knockout, drug delivery, pharmacokinetics (ADME assays), near infrared imaging, behavioral assays, toxicity assays, lethal dose determination, carcinogenesis.
 
 
 
Chapters and reviews (2009-2013)
 
1.   Amin, R., Artmann, T., Artmann, G., Lazarovici, P. and Lelkes, P.I. Permeability of an In Vitro Model of Blood Brain Barrier (BBB). In: IFMBE Proceedings 13th International Conference on Biomedical Engineering (Teck Lim, C. and Goh, JCH, eds) Volume 23, pp 81-84. Springer Berlin Heidelberg, 2009.
2.    Arien-Zakay, H., Lazarovici, P. and Nagler, A. Tissue regeneration potential in human umbilical cord blood. Best Pract Res Clin Haematol 23: 291-303. 2010.
3.    Arien-Zakay H., Lecht S., Nagler A. and Lazarovici P. The Neuroprotective Potential of Human Umbilical Cord Blood Stem Cells in Ischemic Brain Injury - A Novel Therapeutic Strategy. Int J Mol Sci 21: 3513-3528, 2010.
4.    Lecht S., Marcinkiewicz C., Lelkes P.I. and Lazarovici P. Snake venom angioneurins: toxic or therapeutic growth factors? Neurotoxicology 31: 608-620, 2010.
5.     Lazarovici P., Arien-Zakay H., Lecht S., Galski H., Shohami E., Nagler A., Marcinkiewicz C. and Lelkes P.I.. Nerve growth factor and human umbilical cord blood-derived cells confer neurovascular protection in ischemia. Am J Neuroprotec Neuroregen. 3:1-8, 2011.
6.    Momic T., Arlinghaus F.T., Arien-Zakay H., Katzhendler J., Eble J.A., Marcinkiewicz C. and Lazarovici P. Pharmacological aspects of Vipera xantina palestinae venom. Toxins (Basel). 3(11):1420-32, 2011.
7.    Arien-Zakay H., Lecht S., Nagler A. and Lazarovici P. Neuroprotection by human umbilical cord blood derived progenitors in ischemic brain injuries. Arch Ital Biol. 149(2):233-45,2011.
8.    Wang H. , Zhang Q. , Wen Q. , Zheng Y. , Lazarovici P. , Jiang H., Lin J. and Zheng W.H . Proline-rich Akt substrate of 40 kDa (PRAS40): A Novel Downstream Target of PI3k/Akt Signaling Pathway.2011.Cellular Signalling. 24:17-24, 2012.
9.    Gincberg G., Arien-Zakay H., Lazarovici P. and Lelkes PI. Neural stem cells: therapeutic potential for neurodegenerative diseases. British Medical Bulletin. 104:7-19, 2012.
10.  Momic T. , Katzhendler J. , Marcinkiewicz C. , Eble J.A.  and Lazarovici P. Medicinal chemistry approach for solid phase synthesis of peptide mimetics of viperistatin disintegrin as lead compounds for α1/α2 integrin receptors. PEPTIDES 2012 (G Kokotos, V Constantinou-Kokotou and J Matsoukas eds), pp 304-306, University of Athens, Greece, 2012.
11.  Cohen G and Lazarovici P. Molecular Imaging of tumor receptor and signaling molecules using near-infrared nano-approches. In the upcomming special addition on Bioimaging, Biomaterials and Bioimaging of Nanotechnology Series ,(JN Govil ed), vol. 12, In press, 2013.
12.  Gincberg G., Nagler A., Elchalal U. , Lelkes P.I. and Lazarovici P. Cord blood mononuclear and derived NGF-responsive stem cells induced neuroprotection in ischemic models. EBRI- European Journal of Neurodegenerative Disorders. In press, 2013.
 
 
 
 
Articles (2009-2013)
 
1.  Arien-Zakay, H., Lecht, S., Perets, A., Roszell, B., Lelkes, P.I. and Lazarovici P. Quantitative assessment of neuronal differentiation in three-dimensional collagen gels using enhanced green fluorescence protein expressing PC12 pheochromocytoma cells. J Mol Neurosci 37:225-37, 2009.
2.  Arien-Zakay, H., Lecht, S., Bercu, M.M., Tabakman, R., Kohen, R., Galski, H., Nagler, A. and Lazarovici, P. Neuroprotection by cord blood neural progenitors involves antioxidants, neurotrophic and angiogenic factors. Exp Neurol. 216:83-94, 2009.
3.   Arien-Zakay, H., Lecht, S., Bercu, M.M., Amariglio, N., Rechavi, G., Galski, H., Lazarovici, P. and Nagler A. Interferon-gamma induced neuronal differentiation of human umbilical cord blood-derived progenitors. Leukemia. 23:1790-800, 2009.
4.  Staniszewska, I., Walsh, E.M., Rothman, V.L., Gaathon, A., Tuszynski, G.P., Calvete, J.J., Lazarovici, P. and Marcinkiewicz C. Effect of VP12 and viperistatin on inhibition of collagen receptors-dependent melanoma metastasis. Cancer Biology and Therapy. 8:1507-16, 2009.
5.   Lecht, S., Arien-Zakay, H., Marcinkiewicz, C., Lelkes, P.I. and Lazarovici, P.. Nerve growth factor-induced protection of brain capillary endothelial cells exposed to oxygen-glucose deprivation involves attenuation of Erk phosphorylation. J Mol Neurosci. 41:183-92, 2010.
6.  Lecht, S., Foerster, C., Arien-Zakay, H., Marcinkiewicz, C.,Lazarovici, P. and Lelkes PI.. Cardiac microvascular endothelial cells express and release nerve growth factor but not fibroblast growth factor-2. In Vitro Cell Dev Biol. 46:469-76, 2010.
7.  Lecht, S., Arien-Zakay, H., Kohan, M., Lelkes, P.I. and Lazarovici, P. Angiostatic effects of K252a, a Trk inhibitor, in murine brain capillary endothelial cells. Mol Cell Biochem. 339:201-213, 2010.
8.  Lecht, S., Arien-Zakay, H., Wagenstein, Y., Inoue, S., Marcinkiewicz, C., Lelkes, P.I. and Lazarovici, P.. Transient signaling of Erk1/2, Akt and PLCgamma induced by nerve growth factor in brain capillary endothelial cells. Vasc Pharmacol. 53:107-114, 2010.
9.  Leiser, Y., Silverstein, N., Blumenfeld, A., Shilo, D., Haze, A., Rosenfeld, E., Shay, B., Tabakman, R., Lecht, S., Lazarovici, P. and Deutch, D. The induction of tuftelin expression in PC12 cell line during hypoxia and NGF induced differentiation. J Cell Physiol. 226:165-172. 2011.
10.   Pimton, P., Sarkar, S., Sheth, N., Perets, A., Marcinkiewicz, C. ,Lazarovici P. and Lelkes, P.I. Fibronectin-mediated upregulation of α5β1 integrin and cell adhesion during differentiation of mouse embryonic stem cells. Cell Adh Migr. 5:73 -82. 2011.
11.   Han, J., Lazarovici, P., Pomerantz, C., Chen, X., Wei, Y. and Lelkes, P.I. Co-electrospun blends of PLGA, gelatin, and elastin as potential non-thrombogenic scaffolds for vascular tissue engineering. Biomacromolecules. 12: 399-408. 2011.
12.   Portnoy, E., Lecht, S., Lazarovici, P., Magdassi, S. Cetuximab-labeled liposomes containing NIR probe for in vivo imaging. Nanomedicine.7:480-488. 2011.
13.   Nassar, T., Attili-Qadri, S., Harush-Frenkel, O., Farber, S., Lecht, S., Lazarovici, P.  and Benita, S. A novel oral nanotransporter system based on nanocapsules elicits very high plasma levels of docetaxel in rats and favored lymphatic uptake. Cancer Res. 71: 3018-3028. 2011.
14.    Deutsch, D., Silverstein, N.C., Shilo, D., Lecht, S., Lazarovici, P. and Blumenfeld, A. Biphasic influence of hypoxia on tuftelin expression in mouse mesenchymal C3H10T1/2 stem cells. European Journal of Oral Sciences. Suppl 1:55-61, 2012.
15.   Frohbergh, M.E., Katsman, A., Botta, G.P., Lazarovici, P., Schauer, C.L., Wegst, U.G. and Lelkes, P.I. Electrospun hydroxyapatite-containing chitosan nanofibers crosslinked with genipin for bone tissue engineering. Biomaterials. 33:9167-9178, 2012.
16.   Ettinger, K., Lecht, S., Arien-Zakay, H., Cohen, G., Aga-Mizrachi, S., Yanay, N., Saragovi, H.U., Nedev, H., Marcinkiewicz, C., Nevo, Y. and Lazarovici, P. Nerve growth factor stimulation of ERK1/2 phosphorylation requires both p75(NTR) and α9β1 integrin and confers myoprotection towards ischemia in C2C12 skeletal muscle cell model.Cell Signal. 24:2378-2388. 2012.
17.  Saglam, A., Perets, A., Canver, A.C., Li, H.L., Kollins, K., Cohen, G., Fischer, I., Lazarovici, P. and Lelkes, P.I..Angioneural Crosstalk in Scaffolds with Oriented Microchannels for Regenerative Spinal Cord Injury Repair. J Mol Neurosci. 49:334-346, 2013.
18.   Lazarovici, P, Cohen, G., Arien-Zakay, H., Chen, J., Zhang, C., Chopp, M. and Jiang, H.Multimodal Neuroprotection Induced by PACAP38 in Oxygen-Glucose Deprivation and Middle Cerebral Artery Occlusion Stroke Models. J Mol Neurosci. 48:526-40. 2012.
19.   Lecht, S., Rotfeld, E., Arien-Zakay, H., Tabakman, R., Matzner, H., Yaka, R., Lelkes, P.I. and Lazarovici, P. Neuroprotective effects of nimodipine and nifedipine in the NGF-differentiated PC12 cells exposed to oxygen-glucose deprivation or trophic withdrawal. Int J Dev Neurosci. 30: 465-9. 2012 .
20.   Walsh, E.M., Kim, R., Del Valle, L., Weaver, M., Sheffield, J., Lazarovici, P. and Marcinkiewicz, C. Importance of interaction between nerve growth factor and α9β1 integrin in glial tumor angiogenesis. Neuro Oncol. 14:890-901. 2012.
21.   Lin, L., Perets, A., Har-El, Y.E., Varma, D., Li, M., Lazarovici, P., Woerdeman, D.L. and Lelkes, P.I. Alimentary 'green' proteins as electrospun scaffolds for skin regenerative engineering. J Tissue Eng Regen Med. 2012. (Epub ahead of print).
22.   Momic, T., Cohen, G., Reich, R., Arlinghaus, F.T., Eble, J.A., Marcinkiewicz, C. and Lazarovici, P. Vixapatin (VP12), a C-type lectin protein from Vipera xantina palestinae (V.x.p.) venom: characterization as a novel anti-angiogenic compound. Toxins (Basel). 4:862-877, 2012.
23.   Cohen, G., Lecht, S., Arien-Zakay, H., Ettinger, K., Amsalem, O., Oron-Herman, M.,Yavin, E., Prus, D. Benita, S., Nissan, A. and Lazarovici, P.Bio-imaging of colorectal cancer models using near infrared labeled epidermal growth factor. PLOS ONE. 7(11): e48803, 2012.
24.   Bercu, M.M., Arien-Zakay, H., Stoler, D., Lecht, S., Lelkes, P.I., Samuel, S., Or, R., Nagler, A., Lazarovici, P. and Elchalal, U. Enhanced Survival and Neurite Network Formation of Human Umbilical Cord Blood Neuronal Progenitors in Three-Dimensional Collagen Constructs. J Mol Neurosci. 2012. (Epub ahead of print).
25.   Strande, J.L., Routhu, K.V., Lecht, S., and Lazarovici, P. Nerve growth factor reduces myocardial ischemia/reperfusion injury in rat hearts. J Basic Clin Physiol Pharmacol. 11:1-4, 2013.
26.   Arlinghaus, F.T., Momic, T., Ammar, N.A., Shai, E., Spectre, G., Varon, D., Marcinkiewicz, C., Heide, H., Lazarovici, P. and Eble, J.A. Identification of α2β1 integrin inhibitor VP-i with anti-platelet properties in the venom of Vipera palaestinae. Toxicon. 64: 96-105, 2013.
27.   Jakubowski. P., Calvete, J.J., Eble, J.A., Lazarovici, P. and Marcinkiewicz, C. Identification of inhibitors of α2β1 integrin, members of C-lectin type proteins, in Echis sochureki venom. Toxicol Appl Pharmacol. 269: 34-42, 2013.
28.   Han, J., Gerstenhaber, J.A., Lazarovici, P. and Lelkes, P.I. Tissue factor activity and ECM-related gene expression in human aortic endothelial cells grown on electrospun biohybrid scaffolds. Biomacromolecules. 14: 1338-1348, 2013.
29.   Karatzas, A., Katsanos, K., Lilis, I., Papadaki, H., Kitrou, P., Lecht, S., Marcinkiewicz, C., Siablis, D., Lelkes, P.I., Lazarovici, P. and Tsopanoglou, N.E. NGF promotes hemodynamic recovery in a rabbit hindlimb ischemic modelthrough trkA- and VEGFR2-dependent pathways. J Cardiovasc Pharmacol. 2013. (Epub ahead of print).
30.   Galski, H., Oved-Gelber, T., Simanovsky, M, Lazarovici, P., Gottesman, M.M. and Nagler, A. P-glycoprotein-dependent resistance of cancer cells toward the extrinsic TRAIL apoptosis signaling pathway. Biochem Pharmacol. 2013. (Epub ahead of print).
31.   Cohen G, Lecht S, Oron-Herman M, Momic T, Nissan A, Lazarovici P. Near Infrared Optical Visualization of Epidermal Growth Factor Receptors Levels in COLO205 Colorectal Cell Line, Orthotopic Tumor in Mice and Human Biopsies. Int J Mol Sci. 14:14669-14688. 2013.
32.   Ettinger K, Cohen G, Momic T, Lazarovici P. The effects of a chactoid scorpion venom and its purified toxins on rat blood pressure and mast cells histamine release. Toxins 5:1332-1342. 2013.
 
 
 
Abstracts (2009-2013)
 
2009- Inaugurating Meeting of the Israeli Society of Cancer Research. Tel Aviv, Israel.
    Lazarovici, P., Brown, M.C., Staniszewska, I., Tuszynski, P.G., Del Valle, L. and Marcinkiewicz, C. Regulation effect of nerve growth factor in a9b1 integrin-dependent progression of glioblastoma.
     Lecht, S., Riech, R., Davidson, B., Marcinkiewicz, C., Lelkes, PI. and Lazarovici P. Nerve growth factor: novel angiogenic growth factor.
2009 - New horizons in Cellular and Molecular Biology of the 21st Century.  Bar Ilan, Israel.
     Lecht, S., Marcinkiewicz, C., Lelkes, PI. And Lazarovici P. Nerve growth factor angiogenic effects involve TRKA receptor activation of ERK, PI3K/AKT and PLCgamma signaling.
     Arien-Zakay, H., Lecht, S., Bercu, MM. Tabakman, R., Kohen, R., Galski, H., Nagler, A., Lazarovici, P. Neuroprotection by cord blood neural progenitors involves antioxidants, neurotrophic and angiogenic factors.
2009 - Israel Society for Physiology and Pharmacology (ISPP). Ma'ale Hachamisha, Israel.
     Lecht, S., Arien-Zakay, H., Lelkes, P.I. and Lazarovici, P. Differential temporal activation of Erk, PI3K/Akt and PLCg signaling pathways induced by NGF in endothelial cells.
     Arien-Zakay, H., Lecht, S., Nagler, A. and Lazarovici, P. IFNg and NGF-responsive neuronal progenitors from human umbilical cord blood.
     Ettinger, K., Mizrachi, S., Marcinkiewicz, C., Nevo, Y. and Lazarovici, P. The role of NGF and its receptors TrkA, p75 and a9b1 integrin on skeletal muscle regeneration.
2009 - The 10th Scientific Meeting of the Israeli Association for Bone Transplantation, Tel-Hashomer, Israel.
     Arien-Zakay, H., Galski, H., Lazarovici, P. and Nagler, A. Neurological tissue regeneration potential from UCB.
2010- 2nd Annual Meeting of Israeli Society for Cancer Research. Rehovot, Israel. Lecht, S., Arien-Zakay, H., Kohan, M., Lelkes, P.I. and Lazarovici, P. Angiostatic effects of K252a, a Trk inhibitor, in murine brain capillary endothelial cells.
2010 - NGF 2010 - Neurotrophic Factors in Health and Diseases. Helsinki, Finland.
     Arien-Zakay, H., Lecht, S., Shohami, E., Galski, H., Nagler, A. and Lazarovici, P. Neuroprotective potential of NGF-responsive neuronal progenitors from human umbilical cord blood.
 2010 - The Hebrew University Center for Nanoscience and Nanotechnology Annual Conference. Ashkelon, Israel.
     Nassar, T., Attili-Qadri, S., Harush-Frenkel, O., Farber, S., Lecht, S., Lazarovici, P. and Benita, S.The potential switch from intravenous to oral docetaxel therapy by stealth nanocapsule delivery system.
2010 - FISEB (ILANIT). Eilat, Israel.
     Benita, S., Nassar, T., Attilli-Qadri, S., Farber, S., Lecht, S., Lazarovici, P.. A novel nanoparticulate delivery system enhances markedly the oral docetaxel absorption following Pgp bypass.
2010 - Experimental Biology – ASPET. Washington, DC,USA.
     Ettinger, K., Arien-Zakay, H., Mizrachi, S., Marcinkiewicz, C., Nevo, Y. and Lazarovici, P. Nerve growth factor (NGF) and its receptors in skeletal muscle signaling.
2011 - 3th Annual Meeting of the Israeli Society for Cancer Research. Jerusalem, Israel.
     Cohen, G., Lecht, S., Arien-Zakay, H., Oron-Herman, M., Nissan, A. and Lazarovici, P. A near-infrared-based imaging technological platform for colorectal cancer diagnosis.
2011 - Gordon Conference on Fibronectin, Integrins and Related Molecules. Lucca (Barga), Italy.
     Lazarovici, P. Fibronectin-mediated up-regulation of a5b1 integrin and cell adhesion  during differentiation of mouse embryonic stem cells.
2011 - 8th Enamel Conference. Utica, Illinois, USA.
     Silverstein, N., Shilo, D., Lecht, S., Lazarovici, P., Blumenfeld, A. and Deutsch, D.  The influence of hypoxia on tuftelin expression in C3H10T1/2 cells.
2011 - The 13th International Symposium of The Society of Chinese Bioscientists in America. Guangzhou, China.
     Su, X., Meng, Q., Liao, S., Wang, F., Lazarovici, P. and Zheng, W.H. Tanshinone 2A inhibited IGF-1-induced proliferation of PC12 cells by activating receptor tyrosine phosphatase SHP-2.
2011 - Israel Society for Physiology and Pharmacology (ISPP). Ma'ale Hachamisha, Israel.
     Ettinger, K., Nevo, Y., Lecht, S., Arien-Zakay, H., Mizrachi, S., Yanay, N., Saragovi, U., Marcinkiewicz, C. and Lazarovici, P. Nerve growth factor (NGF) stimulation of ERKs phosphorylation by a cross talk between p75NTR and α9β1 integrin in C2C12 muscle cell model.
     Cohen, G., Lecht, S., Arien-Zakay, H., Ettinger, K., Stoler, D., Amsalem, O., Oron-Herman, M., Yavin, E., Nissan, A., Benita, S. and Lazarovici, P. Near infrared optical imaging of epidermal growth factor receptors  in colorectal tumors.
     Momic, T., Arlinghaus, F.T., Arien-Zakay, H., Katzhendler, J., Eble, J.A., Marcinkiewicz, C. and Lazarovici, P. VP12 - pharmacological tool for development of novel drugs selective for α2β1 integrin.
2012 - 7th International Symposium on Neuroprotection and Neurorepair. Postdam, Germany.
     Netzer, N., Abraham, E., Zahavi-Goldstein, E., Wadmany, M., Raveh-Shoval, S., Lahiani, A., Arien-Zakay, H. and Lazarovici, P. 3D cultured placental derived MSC-like cells for cell therapy-from the lab to the clinic.
2012 - 5th Triennial Seminar on  Brain Malfunction and Degeneration. Maale Hachamisha, Israel.
     Cohen, G. and Lazarovici, P. Bioimaging of NGF-induced down regulation of EGF receptors in PC12 sympathetic neuronal model.
     Arien-Zakay, H., Shohami, E. and Lazarovici, P. Human umbilical cord blood stem cells for treatment of traumatic brain injury.
     Ettinger, K., Nevo, Y., Lecht, S., Arien-Zakay, H., Mizrachi, S., Yanay, N., Saragovi, U., Marcinkiewicz,  C. and Lazarovici, P. NGF stimulation of ERKs phosphorylation by a cross talk between p75 and α9β1 integrin in C2C12 muscle cell model.
     Lazarovici, P., Brown, M.C., Staniszewska, I., Tuszynski, G.P., Del Valle, L., and Marcinkiewicz, C. Regulatory effect of NGF in α9β1 integrin-dependent progression of glioblastoma.
     Momic, T., Arlinghaus, F.T., Arien-Zakay, H., Katzhendler, Y., Eble, J.A., Marcinkiewicz, C. and Lazarovici, P.VP12-pharmacological tool for development of novel CNS drugs selective for α2β1integrin.
2012 - NGF 2012- Neurotrophic factors and plasticity of the nervous system. Wurzburg,Germany.
     Lazarovici, P., Cohen, G., Arien-Zakay, H., Chen, J., Zhang, C., Chopp, M. and Jiang, H. Multimodal neuroprotection induced by PACAP38 in oxygen-glucose-deprivation and middle cerebral artery occlusion stroke models.
2012 - 32nd  European Peptide Symposium. Megaron  Athens, Greece.
    Momic, T., Katzhendler, Y., Marcinkiewicz, C., Eble, J.A. and Lazarovici, P. Medicinal chemistry approach for solid phase synthesis of peptide mimetics of viperistatin disintegrin as lead compounds for α1/α2 integrin receptors.
2012 - Imaging in 2020, 8th meeting. Wyoming, USA.
     Cohen, G., Lecht, S., Arien-Zakay, H., Ettinger, K., Amsalem, O., Oron-Herman, M., Yavin, E., Prus,  D., Benita, S., Nissan, A. and Lazarovici, P. Bio-imaging of colorectal tumors biopsies based on optimization of in vitro CRC models using near infrared labeled epidermal growth factor.
2013-Israel Society for Physiology and Pharmacology. Ma'ale Hachamisha, Israel.
     Cohen, G., Lecht, S., Arien-Zakay, H., Ettinger, K., Amsalem, O., Oron-Herman, M., Yavin, E., Prus, D., Benita, S., Nissan, A. and Lazarovici, P. Bio-Imaging of Colorectal Cancer Models Using Near Infrared Labeled Epidermal Growth Factor.
     Lahiani, A., Arien-Zakay, H., Cohen, G., Zahavi-Goldstein, E., Abraham, E., Wadmany, M., Netzer, N., Grynspan, F. and Lazarovici, P. Neuroprotective effect of human PLacental eXpanded mesenchymal stromal cell (PLX) using rat PC12 sympathetic neurons exposed in vitro to oxygen-glucose-deprivation (OGD) insult.
     Arien-Zakay, H., Nagler, A., Gincberg, G., Cohen, G., Trembovler, V., Alexandrovich, A.G., Galski, H., Shohami, E. and Lazarovici P. Human cord blood CD45+ hematopoietic cells protect mice brain after closed head injury.
     Momic, T., Arlinghaus, F.T., Abu Ammar, N., Shai, E., Spectre, G., Varon, D., Eble, J.A., Marcinkiewicz, C. and Lazarovici, P. Detection of α2β1 integrin inhibitor with anti-platelet properties in the venom of Vipera palaestinae.
2013 - 8th Annual Conference of The Israeli Society of Gene & Cell Therapy (ISGCT), Jerusalem, Israel.  
     Arien-Zakay, H., Gincberg, G., Cohen, G., Bercu, M.M., Trembovler, V., Alexandrovich, A.G., Lecht, S., Samuel, S., Nagler, A., Galski, H., Lelkes, P.I. Or, R., Elchalal, U., Shohami, E. and Lazarovici, P. Enhanced survival and neurite network formation of cord blood neuronal-progenitors in three-dimentional (3D) collagen constructs and hematopoietic CD45+ cells induced protection in mice with traumatic brain injury
2013 - Israstem
     Nagler, A., Arien-Zakay, H. and Lazarovici, P. Human umbilical cord blood more than a source of hematopoietic stem cells: neurological potential.
2013 – Israel Society of Neurosurgery
     Bercu, M.M., Arien-Zakay, H., Stoler, D., Lecht, S., Lelkes, P.I., Samuel, S., Or, R., Nagler, A., Lazarovici, P. and Elchalal, U. Enhanced survival and neurite network formation of human umbilical cord blood neuronal progenitors in three-dimentional collagen constructs.
2013The Fifth Annual Meeting of the Israeli Society for Cancer Research. Beer Sheva, Israel.
     Cohen, G., Lecht, S., Oron-Herman, M. and Lazarovici, P. A novel platform for colorectal cancer near infrared bio-imaging, measuring growth factor receptor expression.
2013 – 18th Congress of European Hematology Association,  Stockholm, Sweden
     Arien-Zakay, H., Nagler, A., Gincberg, G., Cohen, G., Shohami, E. and Lazarovici, P. Human cord blood CD45+ cells protect mice brain after closed head injury.
 
 
 
 
Selected Patents
Magdassi S, Lazarovici P, Larush L, Portnoy E, Lecht S, Tivony R. Near Infrared Fluorescent Particles and Uses Thereof. / Particules Fluorescentes Dans L'infrarouge Proche et Leurs Utilisations. YISSUM Research and Development of The Hebrew University of Jerusalem. Mar, 15 2012: WO 2012/032524
 
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