Somach Sachs Prize for “best research by a scientist below 35 at the Weizmann Institute”, 1964.
Distinguished Visiting Professorship, Ohio State University, Columbus, Ohio, 1982-1983.
“Pharmacology, Biochemistry and Behavior” Nov. 1991 issue dedicated to R.Mechoulam. for achievements in the cannabinoid field.
Kolthof Prize in Chemistry, 1994, The Technion, Haifa.
Elected, Member Israel Academy of Sciences, 1994.
Ulf von Euler Lecture in Physiology, Karolinska Institute. Stockholm, Sweden, 1994.
Hanus Medal, 1998, by the Czech Chemical Society in recognition of contribution to cannabinoid chemistry.
David R. Bloom Prize, 1998, for “excellence in pharmaceutical research”, Hebrew University.
The International Cannabinoid Research Society (ICRS) establishes an annual award to be named The R. Mechoulam Annual Award in Cannabinoid Research, 1999.
Israel Prize in Exact Sciences – chemistry, 2000.
Ariens Award and Lecture. 2000. Dutch Pharmacological Society sponsored by Solvay Pharmaceuticals. Amsterdam.
Doctor Honoris Causa, Ohio State University, Columbus, Ohio, 2001.
Elected, Honorary Member, Israel Society of Physiology and Pharmacology, 2002.
Heinrich Wieland Prize, to promote research on “lipids and related substances in the fields of Chemistry, Biochemistry, Physiology, and Clinical Medicine”, Munich, Germany, 2004.
Henrietta Szold Prize for achievements in medical research, Tel-Aviv Municipality, June 2005.
Doctor Honoris Causa, Complutense University, Madrid, 2006.
ECNP (European College of Neuropsychopharmaclogy), Lifetime Achievement Award, Paris, 2006.
ICRS (International Cannabinoid Research Society) Special Award For lifetime achievements in the cannabinoid field, Cologne, Germany, 2007.
Israel Chemical Society Prize for excellence in research, Feb. 2009.
Hebrew University, Medical Faculty Prize for excellence in research, June 2010.
Eicosanoid Research Foundation Lifetime Achievement Award, Seattle, Washington, September, 2011.
NIDA Discovery Award, NIH, Bethesda, September 2011.
Rothschild Prize by Keren Hanadiv (The Rothschild Family Foundation), Jerusalem (in the Knesset) 2012.
EMET Prize – to be presented by the Prime Minister in November, 2012.