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  • Prof.  Raphael Mechoulam
Prof Raphael Mechoulam
Research Projects
Chemistry and biological effects of natural products and drugs. Specifically, the research projects in my laboratory at present cover chemistry of endogenous cannabinoids (isolation, structure elucidation, synthesis), as well as synthesis of novel compounds to be tested as drugs against pain, inflammation, high blood pressure and cancer. The mechanism of action of action of these endogenous cannabinoids and synthetic drugs are investigated.
Grant support: US National Institutes of Health.
 Curriculum Vitae
Professor Raphael Mechoulam

1930 Born Sofia, Bulgaria.
1952 M.Sc. in Biochemistry, Hebrew University, Jerusalem.
1953-56 Army Service.
1956-58 Ph.D. studies with Professor F. Sondheimer, Weizmann Institute, Rehovot.   Research on steroid synthesis.
1959-60 Postdoctoral research at Rockefeller Institute, New York.  Research on structure of triterpenes.
1960-65 Junior and later Senior Scientist, Weizmann Institute. 
             Resesearch on chemistry of natural products, including cannabinoids, terpenes, alkaloids.
1966 Hebrew University, Jerusalem; 1968 – Associate Professor; 1972 –Professor.
1975 Endowed chair: Lionel Jacobson Professor of Medicinal Chemistry.
1979-82 Rector (Academic Head) of Hebrew University.
1983-85 Pro-Rector, Hebrew University.
1993-94 Visiting Professor, Departments of Pharmacology and Medicinal Chemistry, Virginia Commonwealth University,
             Medical College of  Virginia, Richmond, USA.
1999-2000 Pressident of the International Cannabinoid Research Society.

2007 Head, Natural Sciences Section, Israel Academy of Sciences.

Scientific Interest
Chemistry and biological activity of natural products and synthetic drugs.
Published ca. 390 scientific articles.

I have numerous contacts with Israeli and foreign companies, several of which have licensed our compounds and are developing them. I consult for a pharmaceutical company.
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CollaborationsI collaborate with colleagues in Israel – in Jerusalem, Tel-Aviv, Beer Sheba and Haifa in various biomedical and medical fields. I collaborate with numerous groups in the US, Canada, Spain, Germany and Italy.
Laboratory Techniques  
The techniques used in my laboratory depend on the research project – organic synthetic methods for the chemical projects, physical techniques for structure elucidation, and a variety of biochemical and pharmacological techniques for the biological and pharmacological projects.
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Books edited

I have edited 4 books the most recent of which is  
R. Mechoulam (ed) Cannabinoids as Therapeutics, Birkhauser Verlag,  Basel, 2005.
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Books Chapters and Patents

I have published numerous book chapters and have about 25 patents.  
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I have received numerous honors:
Somach Sachs Prize for “best research by a scientist below 35 at the Weizmann Institute”, 1964.
Distinguished Visiting Professorship, Ohio State University, Columbus, Ohio, 1982-1983.
“Pharmacology, Biochemistry and Behavior” Nov. 1991 issue dedicated to R.Mechoulam. for achievements in the cannabinoid field.
Kolthof Prize in Chemistry, 1994, The Technion, Haifa.
Elected, Member Israel Academy of Sciences, 1994.
Ulf von Euler Lecture in Physiology, Karolinska Institute. Stockholm, Sweden, 1994.
Hanus Medal, 1998, by the Czech Chemical Society in recognition of contribution to cannabinoid chemistry.
David R. Bloom Prize, 1998, for “excellence in pharmaceutical research”, Hebrew University.
The International Cannabinoid Research Society (ICRS) establishes an annual award to be named The R. Mechoulam Annual Award in Cannabinoid Research, 1999.
Israel Prize in Exact Sciences – chemistry, 2000.
Ariens Award and Lecture. 2000.  Dutch Pharmacological Society sponsored by Solvay Pharmaceuticals.  Amsterdam.
Doctor Honoris Causa, Ohio State University, Columbus, Ohio, 2001.
Elected, Honorary Member, Israel Society of Physiology and Pharmacology, 2002.
Heinrich Wieland Prize, to promote research on “lipids and related substances in the fields of Chemistry, Biochemistry, Physiology, and Clinical Medicine”, Munich, Germany, 2004.
Henrietta Szold Prize for achievements in medical research, Tel-Aviv Municipality, June 2005.
Doctor Honoris Causa, Complutense University, Madrid, 2006.
ECNP (European College of Neuropsychopharmaclogy), Lifetime Achievement Award, Paris, 2006.
ICRS (International Cannabinoid Research Society) Special Award For lifetime achievements in the cannabinoid field, Cologne, Germany, 2007.
Israel Chemical Society Prize for excellence in research, Feb. 2009.
Hebrew University, Medical Faculty Prize for excellence in research, June 2010.
Eicosanoid Research Foundation Lifetime Achievement Award, Seattle, Washington, September, 2011.
NIDA Discovery Award, NIH, Bethesda, September 2011.
Rothschild Prize by Keren Hanadiv (The Rothschild Family Foundation), Jerusalem  (in the Knesset) 2012. 
EMET Prize – to be presented by the Prime Minister in November, 2012.

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