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Researchers
  • Prof.  Reuven Laskov
Prof Reuven Laskov
 

Publications

Reynaud CA, Moutel S, Dieu-Nosjean MC, Laskov R, Teillaud JL. 1(st) French-Israeli International Conference on B Cells and therapeutic antibodies: October 23-25, 2011 Jerusalem, Israel. MAbs. 2012 Jul-Aug;4(4):426-33.

Laskov R, Yahud V, Hamo R, Steinitz M. Preferential targeting of somatic hypermutation to hotspot motifs and hypermutable sites and generation of mutational clusters in the IgVH alleles of a rheumatoid factor producing lymphoblastoid cell line. Mol Immunol. 2011 Feb;48(5):733-4

Chezar I, Lobel-Lavi L, Steinitz M, Laskov R. Ongoing somatic hypermutation of the rearranged VH but not of the V-lambda gene in EBV-transformed rheumatoid factor-producing lymphoblastoid cell line. Mol Immunol. 2008 Nov;46(1):80-90.

Berger N, Ben Bassat H, Klein BY, Laskov R. Cytotoxicity of NF-kappaB inhibitors Bay 11-7085 and caffeic acid phenethyl ester to Ramos and other human B-lymphoma cell lines. Exp Hematol. 2007 Oct;35(10):1495-509.

Gil Y, Levy-Nabot S, Steinitz M, Laskov R. Somatic mutations and activation-induced cytidine deaminase (AID) expression in established rheumatoid factor-producing lymphoblastoid cell line. Mol Immunol. 2007 Jan;44(4):494-505.

Laskov R, Berger N, Scharff MD, Horwitz MS. Tumor necrosis factor-alpha and CD40L modulate cell surface morphology and induce aggregation in Ramos Burkitt's lymphoma cells. Leuk Lymphoma. 2006 Mar;47(3):507-19.

Laskov R, Berger N, Horwitz MS. Differential effects of tumor necrosis factor-alpha and CD40L on NF-kappa B inhibitory proteins I kappa B alpha, beta and epsilon and on the induction of the Jun amino-terminal kinase pathway in Ramos Burkitt lymphoma cells. Eur Cytokine Netw. 2005 Dec;16(4):267-76.

Gabay C, Ben-Bassat H, Schlesinger M, Laskov R. Somatic mutations and intraclonal variations in the rearranged Vkappa genes of B-non-Hodgkin's lymphoma cell lines. Eur J Haematol. 1999 Sep;63(3):180-91.

Riss J, Laskov R. Expression of novel alternatively spliced isoforms of the oct-1 transcription factor. Biochim Biophys Acta. 1999 Feb 16;1444(2):295-8.

Hochberg M, Gabay C, Laskov R. Somatic mutations in the Ig variable region genes and expression of novel Cmu-germline transcripts in a B-lymphoma cell line ("Farage") not producing Ig polypeptide chains. Leuk Lymphoma. 1998 Aug;30(5-6):637-49.

Baruch M, Hochberg M, Gabay C, Ben-Bassat H, Shlomai Z, Laskov R. Molecular characterization of an unusual non-Hodgkin's B-lymphoma cell line ("Farage") lacking the ability to produce immunoglobulin polypeptide chains. Leuk Lymphoma. 1996 May;21(5-6):485-95. PubMed PMID: 9172815.

Shurman L, Laskov R, Bergman Y. Direct and indirect mechanisms of repression participate in suppression of T-cell-specific gene expression in T x L-cell hybrids. Gene Expr. 1996;5(6):285-300.

Reich L, Sharir H, Ber R, Wirth T, Bergman Y, Laskov R. Coordinate suppression of myeloma-specific genes and expression of fibroblast-specific genes in myeloma X fibroblast somatic cell hybrids. Somat Cell Mol Genet. 1996 Jan;22(1):1-20.

Jaffe J, Hochberg M, Riss J, Hasin T, Reich L, Laskov R. Cloning, sequencing and expression of two isoforms of the murine oct-1 transcription factor. Biochim Biophys Acta. 1995 Apr 4;1261(2):201-9.

Catalano-Sherman J, Laskov R, Palmon A, David S, Deutsch D. Production of a monoclonal antibody against human amelogenin. Calcif Tissue Int. 1994 Jan;54(1):76-80.

Bergsagel PL, Timblin CR, Eckhardt L, Laskov R, Kuehl WM. Sequence and expression of a murine cDNA encoding PC326, a novel gene expressed in plasmacytomas but not normal plasma cells. Oncogene. 1992 Oct;7(10):2059-64.

Laskov R, Sharir H, Tzieger-Dickbuch S, Hijazzi M, Greenberg A, Ber R. Suppression of the translocated myc gene and expression of intracisternal A-particle genes in tumorigenic and non-tumorigenic hybrids between murine myeloma and normal fibroblasts. Int J Cancer. 1991 Jun 19;48(4):574-82.

Laskov R, Michaeli RI, Sharir H, Yefenof E, Vlodavsky I. Production of heparanase by normal and neoplastic murine B-lymphocytes. Int J Cancer. 1991 Jan 2;47(1):92-8.

Bibi E, Laskov R. Selection and application of antibodies modifying the function of beta-lactamase. Biochim Biophys Acta. 1990 Aug 17;1035(2):237-41.

Laskov R, Lancz G, Ruddle NH, McGrath KM, Specter S, Klein T, Djeu JY, Friedman H. Production of tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) by murine pre-B and B cell lymphomas. J Immunol. 1990 May 1;144(9):3424-30.

Bergman Y, Strich B, Sharir H, Ber R, Laskov R. Extinction of Ig genes expression in myeloma x fibroblast somatic cell hybrids is accompanied by repression of the oct-2 gene encoding a B-cell specific transcription factor. EMBO J. 1990 Mar;9(3):849-55.

Panet R, Amir I, Snyder D, Zonenshein L, Atlan H, Laskov R, Panet A. Effect of Na + flux inhibitors on induction of c-fos, c-myc, and ODC genes during cell cycle. J Cell Physiol. 1989 Jul;140(1):161-8.

French DL, Laskov R, Scharff MD. The role of somatic hypermutation in the generation of antibody diversity. Science. 1989 Jun 9;244(4909):1152-7. Review.

Greenberg A, Hijazzi M, Sharir H, Cohen L, Bergman Y, Ber R, Laskov R. Extinction of expression of the translocated myc gene in somatic cell hybrids between mouse myeloma and L-cells. Int J Cancer. 1989 Jan 15;43(1):87-92.

Deutsch D, Palmon A, Catalano-Sherman J, Laskov R. Production of monoclonal antibodies against enamelin and against amelogenin proteins of developing enamel matrix. Adv Dent Res. 1987 Dec;1(2):282-8.

Greenberg A, Ber R, Kra-Oz Z, Laskov R. Extinction of expression of immunoglobulin genes in myeloma X fibroblast somatic cell hybrids. Mol Cell Biol. 1987 Feb;7(2):936-9.

Rabinowitz R, Hadar R, Laskov R, Schlesinger M. A new autoreactive monoclonal antibody specific for the Thy-1 antigen. Thymus. 1986;8(5):279-94. Erratum in: Thymus 1987;9(4):261.

Pass A, Avidor B, Golenser J, Laskov R, Sulitzeanu D. Use of a monoclonal, anti Plasmodium berghei antibody, cross reacting with P. falciparum, for the detection of P. falciparum in in vitro infected blood. Immunol Lett. 1985;10(1):31-4.

Treves AJ, Fuks Z, Voss R, Tal T, Barak V, Konijn AM, Kaplan R, Laskov R. Establishment of cell lines from somatic cell hybrids between human monocytes and mouse myeloma cells. J Immunol. 1984 Feb;132(2):690-4.

Laskov R, Muller S, Hochberg M, Giloh H, Van Regenmortel MH, Eilat D. Monoclonal autoantibodies to histones from autoimmune NZB/NZW F1 mice. Eur J Immunol. 1984 Jan;14(1):74-81.

Schlesinger M, Levy J, Laskov R, Hadar R, Weinstock J, Ben-Bassat H, Rabinowitz R. The role of E receptors in the attachment of thymocytes and T lymphocytes to human target cells. Clin Immunol Immunopathol. 1983 Dec;29(3):349-58.

Laskov R, Ishay-Michaeli R, Wallach M, Givol D, Kim KJ. Simultaneous expression of mu- and gamma-chain mRNA in cloned murine B-lymphoma cell lines. EMBO J. 1983;2(2):167-72.

Eilat D, Hochberg M, Fischel R, Laskov R. Antibodies to RNA from autoimmune NZB/NZW mice recognize a similar antigenic determinant and show a large idiotypic diversity. Proc Natl Acad Sci U S A. 1982 Jun;79(12):3818-22.

Wallach M, Ishay-Michaeli R, Givol D, Laskov R. Analysis of immunoglobulin mRNA in murine myeloma cell variants defective in the synthesis of the light or heavy polypeptide chains. J Immunol. 1982 Feb;128(2):684-90.

Eilat D, Laskov R. Production of anti-RNA antibody by hybridoma cells: purification from mixed immunoglobulin products. Mol Immunol. 1981 Jul;18(7):589-95.

Laskov R, Kim JK, Woods VL, McKeever PE, Asofsky R. Membrane immunoglobulins of spontaneous B lymphomas of aged BALB/c mice. Eur J Immunol. 1981 Jun;11(6):462-8.

Benbassat J, Hershko C, Laskov R, Eliakim M. Effect of iron deficiency on transplantable murine plasmacytoma. Nutr Cancer. 1981;3(1):20-6.

Eilat D, Ben Sasson SA, Laskov R. A ribonucleic acid-specific antibody produced during autoimmune disease: evidence for nucleotide sequence specificity. Eur J Immunol. 1980 Nov;10(11):841-5.

Laskov R, Kim KJ, Kanellopoulos-Langevin C, Asofsky R. Extinction of B-cell surface differentiation markers in hybrids between murine B-lymphoma and myeloma cells. Cell Immunol. 1980 Oct;55(2):251-64.

Wallach M, Laskov R. A high production rate of translatable IgG mRNA accounts for the amplified synthesis of IgG in myeloma cells. Eur J Biochem. 1980 Sep;110(2):545-54.

Rabinowitz R, Laskov R, Schlesinger M. Inhibition of cell-mediated lysis by xenoantibodies reactive with effector T lymphocytes. Eur J Immunol. 1980 Mar;10(3):219-23.

Eilat D, Asofsky R, Laskov R. A hybridoma from an autoimmune NZB/NZW mouse producing monoclonal antibody to ribosomal-RNA. J Immunol. 1980 Feb;124(2):766-8.

McKeever PE, Kim KJ, Nero GB, Laskov R, Merwin RM, Logan WJ, Asofsky R. Two spontaneous BALB/c lymphomas synthesize IgM: monomers and half molecules are isolated and characterized whereas another molecule resembles IgD. J Immunol. 1979 Apr;122(4):1261-5.

Laskov R, Kim KJ, Asofsky R. Induction of amplified synthesis and secretion of IgM by fusion of murine 'b lymphoma with myeloma cells. Proc Natl Acad Sci U S A. 1979 Feb;76(2):915-9.

Rabinowitz R, Laskov R, Schlesinger M. The effect of xenoantisera on T-lymphocyte functions in the absence of complement. Adv Exp Med Biol.1979;121B:247-60.

Polliack A, Gamliel H, Froimovici M, Laskov R. Myeloma cells: surface morphology as seen by scanning and transmission electron microscopy. Isr J Med Sci. 1978 Dec;14(12):1252-8.

Baumal R, Sklar S, Wilson B, Laskov R. Casein-induced murine amyloidosis: amyloidogenesis in vitro by monolayer spleen explants of casein-injected mice. Lab Invest. 1978 Dec;39(6):632-9.

Rabinowitz R, Laskov R, Schlesinger M. Antigenic properties of lymph-node cells responding to allogeneic lymphocytes and to various concentrations of lectins. Immunology. 1978 Jun;34(6):959-67.

Laskov R, Baumal R, Polliack A. Surface morphology of cultured myeloma cells: bleb formation in cell variants with defects in immunoglobulin production and secretion. J Reticuloendothel Soc. 1978 May;23(5):361-72.

Polliack A, Nilsson K, Laskov R, Biberfeld P. Characteristic surface morphology of human and murine myeloma cells: a scanning and transmission electron microscopic study. Br J Haematol. 1978 May;39(1):25-32.

Laskov R, Kimm KJ, Asofsky R. Induction of IgM secretion by fusing murine B-lymphoma with myeloma cells. Curr Top Microbiol Immunol. 1978;81:173-5.

Laskov R, Rabinowitz R, Haimovitz A, Schlesinger M. Cell surface antigens as differentiation markers of the B lymphocyte lineage. Isr J Med Sci. 1977 Aug;13(8):767-76.

Naor D, Berman-Goldman R, Kahan M, Goldfisher H, Laskov R, Simon E, Tchakirov R. Induction of hapten recognizing helper function by heavily trinitrophenylated sheep erythrocytes. Adv Exp Med Biol. 1976;66:253-60.

Rabinowitz R, Laskov R, Schlesinger M. Proceedings: Alloantigenic characterization of responder cells in the mixed lymphocyte reaction. Isr J Med Sci. 1975 Dec;11(12):1387.

Solage A, Laskov R. Characterization of cytoplasmic DNA of mouse-myeloma cells. Eur J Biochem. 1975 Dec 1;60(1):23-33.

Solage A, Laskov R. Proceedings: Cytoplasmic DNA in mouse myeloma cells. Isr J Med Sci. 1975 Nov;11(11):1204.

Laskov R, Mitelman S. Immune precipitation of immunoglobulin producing polysomes from mouse myeloma cells. J Immunol. 1975 Feb;114(2 Pt 1):566-70.

Laskov R, Scharff MD. Independent synthesis of light and heavy chains: quantitation of light-chain production by mouse myeloma variants. J Exp Med. 1974 Oct 1;140(4):1112-6.

Rabinowitz R, Cohen A, Laskov R, Schlesinger M. Antibodies specific for the theta- and Ly-alloantigens in various rabbit antisera. J Immunol. 1974 Feb;112(2):683-92.

Laskov R, Rabinowitz R, Schlesinger M. Antigenic characterization of murine rosette and plaque-forming cells. Immunology. 1973 Jun;24(6):939-54.

Laskov R, Simon E. Rosette-forming cells in mice immunized with sheep and chicken red cells. Isr J Med Sci. 1973 Feb;9(2):175-84.

Fields BN, Laskov R, Scharff MD. Temperature-sensitive mutants of reovirus type 3: studies on the synthesis of viral peptides. Virology. 1972 Oct;50(1):209-15.

Coffino P, Baumal R, Laskov R, Scharff MD. Cloning of mouse myeloma cells and detection of rare variants. J Cell Physiol. 1972 Jun;79(3):429-40.

Laskov R. [Myeloma as a tool for elucidation of the mechanism of antibody diversity]. Harefuah. 1972 Jan 16;82(2):78-85. Review. Hebrew.

Baumal R, Coffino P, Bargellesi A, Buxbaum J, Laskov R, Scharff MD. The regulation of immunoglobulin synthesis and assembly. Ann N Y Acad Sci. 1971 Dec 31;190:235-49.

Laskov R, Lanzerotti R, Scharff MD. Synthesis, assembly and secretion of gamma globulin by mouse myeloma cells. II. Assembly of IgG2b immunoglobulin by MPC 11 tumor and culture cells. J Mol Biol. 1971 Mar 14;56(2):327-39.

Scharff MD, Bargellesi A, Baumal R, Buxbaum J, Coffino P, Laskov R. Variations in the synthesis and assembly of immunoglobulins by mouse myeloma cells: a genetic and biochemical analysis. J Cell Physiol. 1970 Dec;76(3):331-48.

Laskov R, Scharff MD. Synthesis, assembly, and secretion of gamma globulin by mouse myeloma cells. I. Adaptation of the Merwin plasma cell tumor-11 to culture, cloning, and characterization of gamma globulin subunits. J Exp Med. 1970 Mar 1;131(3):515-41.

Coffino P, Laskov R, Scharff MD. Immunoglobulin production: method for quantitatively detecting variant myeloma cells. Science. 1970 Jan 9;167(3915):186-8.

Scharff MD, Laskov R. Synthesis and assembly of immunoglobulin polypeptide chains. Prog Allergy. 1970;14:37-80. Review.

Laskov R. Rosette forming cells in non-immunized mice. Nature. 1968 Aug 31;219(5157):973-5.

Laskov R, Simon E, Gross J. Studies on a naturally occurring human antibody active against mouse Landschutz ascites tumor cells. 3. The nature of the antigenic site on the tumor cell. Int J Cancer. 1968 Jul 15;3(4):511-22.

Laskov R, Simon E, Gross J. Studies on a naturally occurring human antibody active against mouse Landschutz ascites tumor cells. I. Cytotoxicity assay system and quantitation in normal sera. Int J Cancer. 1968 Jan 15;3(1):96-106.

Laskov R, Simon E, Ram D, Gross J. Studies on a naturally occurring human antibody active against mouse Landschutz ascites tumor cells. II. Identification of the antibody as IgM and its partial purification. Int J Cancer. 1968 Jan 15;3(1):107-15

Laskov R, Gross J. The Size and Shape of Rat Liver Glycogen Prepared By Phenol Extraction. Isr J Med Sci. 1965 Jan; 1:26-42.

Laskov R, Margoliash E, Littauer UZ, Eisenberg H. High-molecular-weight ribonucleic acid from rat liver. Biochim Biophys Acta. 1959 May;33(1):247-8.

 

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