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Researchers
  • Prof.  Ron Kohen
Prof  Ron Kohen
 

Research Interest

 

        · Antioxidants, (mechanism, natural compounds, new designed antioxidants); 

        · New hypotheses concerning the way antioxidants act in vivo; 

        · Regulation of the antioxidant network; 

        · Delivery of antioxidants;

        · The role of oxidative stress in the aging process (brain, skin, intestinal tract);

        · Biological redox potential and new approaches for evaluating biological redox state;

        · ROS-related diseases; 

        · Development of new methodologies in the field;

 
 
 
Research Projects 
Can exogenous antioxidants modulate the total antioxidant capacity of the organism?
 
Oxidation in the gastrointestinal tract and its relevance to various diseases.
 
The existence of a common mechanism for different types of stress.
 
How do antioxidants work in vivo?
 
New approaches for quantification of the biological redox state.
 
Oxidation processes in the brain and its relevance to brain pathologies. 
 
 
 
Laboratory Techniques
 
Tissue culture
 
Spectroscopy methods (E.g. Electron spin resonance, UV, Fluorescence, Chemiluminescence)
 
Separation techniques
 
Cell biology techniques
 
Animal models of disease states associated with oxidation
 
In vitro simulation of biological oxidation process
 
Electrochemical techniques (E.g. voltammetric measurements).
 
 
 
Chapters and reviews in books and proceedings  
Kohen, R. Diet and its effect on lipoprotein oxidation. In: Diabetes S. Baba and T. Kaneko (eds.), Elsevier Science B. V. pp. 430-435 (1995).
 
Tirosh, O., Katzhendler, Y., Barenholz, Y., Ginsburg, I. and Kohen, R. Amidothionophosphates: Novel antioxidant molecules. In: Phosphorus. Sulfur, and Silicon, Overseas Publishers Association, Amsterdam, 111, 707 (1996).
 
Lomintski,, L., Chen, Y., Shohami, E., Kohen, R. and Michaelson, D.M. Neurochemical derangement and cognitive deficits in apolipoprotein E deficient mice following closed head injury . In: Neurochemistry A. W. Teelken & Y. Korf (eds.), Plenum Press (1996).
 
Kohen, R., Fanberstein, D., Zelkowicz, A., Tirosh, O. and Farfouri, S. Non-invasive in vivo evaluation of skin antioxidant activity and oxidation status. In: Methods in Enzymology L. Packer (ed.), Academic Press, 300, San Diego, CA, pp. 428-437 (1999) (2.435).
 
Tirosh, O., Katzhendler, Y., Barenholz, Y. and Kohen, R. Antioxidant activity of amidothionophosphates. In: Methods in Enzymology L. Packer (ed.), Academic Press 299, San Diego, CA, pp.293-300 (1999).
 
Kohen, R , Beit-Yannai, E.. Berry, E. and Tirosh, O. Evaluation of the overall low molecular weight antioxidant. activity of biological fluids and tissues by cyclic voltammeter. In: Methods in Enzymology L. Packer (ed.), Academic Press 300, San Diego, CA, pp. 285-295 (1999) (2.435).
 
Rubinstein, A., Blau, S., Bass, P. and Kohen, R. The effect of adhesive antioxidant enzymes on experimental colitis in the rat. In: ACS symposium Series 752, Controlled Drug Delivery, Designing Technologies for the Future, K. Park and R.J. Mrsny (eds.), Oxford University Press. pp. 78-89 (2000).
 
Kohen, R. and Niska, A. Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions and methods for their quantification. Toxicol. Pathol. 30:620-650 (2002).
 
Granot, E. and Kohen, R. Oxidative stress in childhood-in health and diseases states. Clin. Nutr. 23:3-11 (2004).
 
Kohen R., Moor E. and Oron, M. Measurements of biological reducing power by voltammetric methods In: Redox- Genome Interaction, Fuchs and L. Packer (eds.), Marcel Dekker Inc. NY. 13-42 (2004).
 

 

 

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