We develop methods and theory in statistical and population genetics, with applications to medicine, biology, and history, in particular in the context of the Jewish population. Current research is focused on the following projects.
Open positions We are looking for talented and motivated PhD students/post-docs with quantitative skills to join the lab. Experience in programming, computer science, and/or statistics is a prerequisite. Projects are available across the spectrum of statistical, population, and medical genetics. Day-to-day work ranges between hands-on medical data analysis and probabilistic modeling, and could fit students with diverse backgrounds and interests.
Ashkenazi Jewish genetics
D. M. Behar, L. Saag, M. Karmin, …, S. Carmi
, S. Tzur
, …, K. Skorecki, M. Metspalu, S. Rootsi, R. Villems. The genetic variation in the R1a clade among the Ashkenazi Levites’ Y chromosome
. Sci. Rep. 7, 14969 (2017).
B. Baskovich, S. Hiraki, K. Upadhyay, P. Meyer, S. Carmi, N. Barzilai, A. Darvasi, K. Offit, S. Bressman, L. Ozelius, I. Peter, J. Cho, G. Atzmon, L. Clark, T. Lencz, I. Pe’er, H. Ostrer, and C. Oddoux. Expanded Genetic Screening Panel for the Ashkenazi Jewish Population. Genet. Med. 18, 522 (2016).
, K. Y. Hui, E. Kochav, X. Liu, J. Xue, F. Grady, S. Guha, K. Upadhyay, D. Ben-Avraham, S. Mukherjee, B. M. Bowen, T. Thomas, J. Vijai, M. Cruts, G. Froyen, D. Lambrechts, S. Plaisance, C. Van Broeckhoven, P. Van Damme, H. Van Marck, N. Barzilai, A. Darvasi, K. Offit, S. Bressman, L. J. Ozelius, I. Peter, J. H. Cho, H. Ostrer, G. Atzmon, L. N. Clark, T. Lencz, and I. Pe’er. Sequencing an Ashkenazi reference panel supports population-targeted personal genomics and illuminates Jewish and European origins
. Nat. Commun.
5, 4835 (2014).
Statistical and population genetics
D. Backenroth, F. Zahdeh, Y. Kling, A. Peretz, T. Rosen, D. Kort, S. Zeligson, T. Dror, S. Kirshberg, E. Burak, E. Levy-Lahad, D. Zangen, G. Altarescu, S. Carmi*, and D. A. Zeevi*. Haploseek: A 24-hour all-in-one method for preimplantation genetic diagnosis (PGD) of monogenic disease and aneuploidy. Submitted (2018).
Selected recent publications in computational biology
RNA and DNA editing
Trypanosoma brucei RNA processing
2011-2015 Post-doctoral scientist, Department of Computer Science, Columbia University. Mentor: Prof. Itsik Pe’er
2010-2011 Post-doctoral fellow, Faculty of Life Sciences, Bar-Ilan University, Israel. Mentor: Dr. Erez Levanon
2005-2010 M.Sc. and Ph.D., Physics , Bar-Ilan University, Israel. Advisor: Prof. Shlomo Havlin
2002-2005 B.Sc., Physics and Computer Science, Bar-Ilan University, Israel.