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Researchers
  • Prof.  Shlomo Rottem
Prof Shlomo Rottem
 
Research Interest
Structure and function of the mycoplasma cell membrane.
 
Bioactive lipid and lipoprotein components from the cell membrane of Mycoplasmas.
 
Inactivation of mycoplasmas with preservation of structural integrity by targeting the hydrophobic domain of the cell Membrane. 
 
 
​Research Projects
        ·       Invasion of eukaryotic cells by Mycoplasma penetrans
 
        ·       Upregulation of the syntesis of host cell proteins by M. hyorhinis
 
        ·       Phosphoproteomics of M. fermentans
 
        ·       The genomics and proteomics of lipid biosynthesis in M. fermentans
 
 
Recent Publications
Atalla H., Lysnyansky I., and Rottem S. 2015. Mycoplasma gallisepticum, inactivated by targeting the hydrophobic domain of the membrane, preserves surface lipoproteins and induces a strong immune response. Plos One (in press)
 
Kornspan J. D., Rottem S. and Nir-Paz R. 2014. Cardiolipin synthetase is involved in the antagonistic interaction (reversed CAMP phenomenon) of Mycoplasma species with Staphylococcus aureus hemolysis. J. Clin. Microbiol. 52, 1622-1628.
 
Kornspan J. D. Tsur M. Tarshis, M., Rottem, S., and Brenner T.  2014. Mycoplasma hyorhinis induces proinflammatory responses in mice lymphocytes. J. Basic Microbiol. 54, 1-6.
 
Kornspan J. D., Ginsburg I, Rottem S. 2013. The oxidant scavenging capacity of the oral Mycoplasma salivarium. Arch Oral Biol. 58, 1378-1384.
 
Rechnitzer, H., Rottem, S., and Herrmann, R.H. 2013. Reconstitution of an active arginine deiminase pathway in Mycoplasma pneumoniae M129. Infect.and Immun. 81, 3742-3749
 
Elkind E, Vaisid T, Kornspan JD, Barnoy S, Rottem S. and Kosower NS. 2012  Calpastatin upregulation in Mycoplasma hyorhinis-infected cells is promoted by the mycoplasma lipoproteins via the NF-κB pathway. Cell Microbiol. 14:840-851
 
Kornspan, J.D. and Rottem, S. 2012. Phospholipase A and glycerophosphodiesterase activities in the cell membrane of Mycoplasma hyorhinis. FEMS Microbiol Letters 332, 34-39.
 
Kornspan, J.D. and Rottem, S. 2012. Phospholipase A and glycerophosphodiesterase activities in the cell membrane of Mycoplasma hyorhinis. FEMS Microbiol Letters 332, 34-39.
 
Kornspan, J.D. and Rottem, S. 2012. The phospholipid profile of Mycoplasmas. J. of Lipids 2012 Article 640762
 
Rottem, S., Kosower N.S. and Kornspan J.K. 2012. “Contamination of tissue cultures by Mycoplasmas”.  Chapter in Biomedical Tissue cultures, INTECH open pub.
 
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