The molecular mechanism of cell migration and cytokinesis
Our research goals are to elucidate the mechanisms that underlie directed cell migration and cytokinesis. Migration contributes to numerous pathological phenomena as well. It plays a pivotal role in the formation of tumors, which requires the invasion of blood vessels, as well as in metastasis, the spread of tumors from the primary tumor mass to distant sites where secondary tumors form. Migration participates centrally in normal tissue regeneration and wound repair and is an issue in successful stem cell transplantation.
Another research goal is the mechanisms that underlie cytokinesis, which is the process in which the cytoplasm of a single eukaryotic cell is divided to form two daughter cells. Unregulated cytokinesis is often associated with tumorigenesis.
Our research focuses on the role of the cytoskeletal proteins actin and myosin II and their regulator proteins, the tumor suppressor Lgl1 and survivin a member of the inhibitor of apoptosis (IAP) family.
In our research we use a variety of techniques such as molecular and cell biology and cell imaging.