Bachrach U. Prof. (Retired)
Nolecular Biology. Cancer
Research was focused on studying the physiological functions of naturally occurring polyamines (spermine, spermidine and putrescine). Special emphasis was given to elucidating their role in promoting growth and malignant transformation. It has been found that they activate protein kinases which are involved in signal transduction. This resulted in stimulated expression of the nuclear oncogenes fos. jun and myc
Based on these studies a new method for determining the sensitivity of cancer cells to chemotherapy and radiotherapy was developed. This in vitro chemosensitivity test, was successfully applied for predicting the optimal treatment for hematological cancer patients. As a result, undesired toxic side effects of anti cancer agents could be reduced.
The mode of anticancer activity of polyphenols derived from green tea was also elucidated.
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Academy of Medical Sciences, Jinan, Shandong, China (In vitro chemosensitivity assays).
University of Vienna, Austria, School of Pharmacy (Attempts to establish an European Polyamine Research Center).
Tabib, A. and Bachrach, U. Polyamines induce malignant transformation in cultured NIH 3T3 fibroblasts. Internat. J. Biochem. Cell Biol. 30, 135-146 (1998).
Tabib, A and Bachrach, U.: Role of polyamines in mediating malignant transformation and oncogene expression. Internat. J. Biochem. Cell Biol. 31, 1289-1295 (1999).
Wang, Y. Ashkenazi, Y.J. and Bachrach, U.: In vitro chemosensitivity testing of hematological cancers: immunohistochemical detection of ornithine decarboxylase. Anti-cancer Drugs 10, 797-805 (1999).
Itova, I., Pavlov, V. Dimitrov, O. and Bachrach, U.: Developmental aspects of polyamine oxidizing enzyme activities in mouse kidney: Effects of testosterone. Amino Acids 17, 267-276 (1999).
Jotova, I. Wang, C., Tabib, A., Dimitrov, O. and Bachrach, U.: Effects of testosterone and 17b-estradiol on the polyamine metabolism in cultivated normal and rat kidney epithelial cells . Amino Acids 18, 353-361 (2000).
Wang, Y. and Bachrach U.: A luminescence-based test for determining ornithine decarboxylase. Analyt. Biochem. 287, 299-302 (2000).
Wang. Y, Or, R. and Bachrach, U.: Chemosensitivity testing of hematological cancers using ornithine decarboxylase as a marker. J. Med. Biol. And Environment 28, 51-56 (2000).
Bachrach, U. Wang, Y-C. and Tabib, A.: Polyamines: New cues in cellular signal transduction. News Physiol. Sci. 16, 106-109 (2001).
Bachrach, U. and Wang, Y-C.: Cancer therapy and prevention by green tea: role of ornithine decarboxylase. Amino Acids 22, 1-13 (2002).
Wang, Y-C. and Bachrach, U.: The specific anti-cancer activity of green tea (-)-epi-gallocatechin-3-gallate (EGCG). Amino Acids 22, 131-143 (2002).
Han, B., Fixler, R., Beeri, R., Wang, Y., Bachrach, U. And Hasin, Y.: The opposing effects of endothelin-1 and C-type natriuretic peptide on apoptosis of neonatal cardiac myocytes. Europ. J. Pharmacol., 474, 15-20 (2003).
Bachrach U. Polyamines and cancer. Amino Acids (in press).
Chapters in Books
Yaniv, Z. and Bachrach, U. Roots as a source of metabolites with medicinal activity. In: Plants Roots , the Hidden Half (Y. Waisel, A. Eshel and Kafkafi, U. eds.) Marcel Decker Inc. N.Y. pp. 1071-1091, 2002.
Bachrach, U. Tabib, A. and Wang, Y.: Polyamines and malignant transformation. In: Biologically Active Amines in Food, COST 917 (D.M.L. Morgan, T. Hirvi, G. Dandrifosse, P. Deloyer and A. White, eds.). European Communities, Luxemburg, pp. 44-47, 2002.
Bachrach, U. and Wang, Y. In vitro chemosensitivity testing of hematological cancer patients: Detection of ornithine decarboxylase. In: Recent Results in Cancer Research, Chemosensitivity Testing in Oncology (U. Reinhold and W. Tilgen, eds.). Springer, Berlin, Vol. 161, pp. 62-70, 2003.
Bachrach, U. Naturally occurring polyamines: interaction with macromolecules. In: Current Protein and Peptide Science (B.M. Dunn, ed.). Bentham Science Publishers Ltd. 2004 ( in press).
Bachrach, U. Immunohistochemical detection of ornithine decarboxylase as a measure of chemosensitivity (R.D. Blumenthal, ed.) Humana Press. 2004 (in press).
Editor of a book:
Yaniv, Z. and Bachrach, U. eds. Handbook of Medicinal Plants, Binghamton, NY, Haworth Press (2004).
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Awards and Medals
Elected as honorary member of Shandong Academy of Medical Siences (China).
Elected member of the Board of Governors of the Institute of Molecular Medicine, Huntington beach, Ca.
Awarded “Qilu Friendship Award” for foreign expert who gives great contribution for the development of the Shandong Academy of Medical Sciences, Shandong, China.
A medal from the University of Roma , Italy.