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  • Prof.  Uri Wormser
Prof Uri Wormser
Research projects  
Development of antidotes against chemical- and heat-induced skin lesions.
Development of drugs for multiple sclerosis.
Development of drugs for systemic lupus erythematosus.
Development of drugs for autoimmune diseases.
The mechanism of action of T regulatory cells and their role in autoimmune diseases.
Research interests
        ·       Drug development for autoimmune diseases and involvement of T regulatory cells in these pathologies.
        ·       Development of antidotes against thermal and chemical skin burns and investigation of their mechanism of action
Chapters and reviews in books and proceedings  
Chorev, M., Gilon, C., Wormser, U., Friedman, Z.Y. and Selinger, Z. (1981),  Structural Requirements at the N-Acylating Residue of Substance P Partial Sequence In: "Peptides 1980, Proceedings of the 16th European Peptide Symposium" (Brunefeldt, K., Ed.) Scriptor, Copenhagen pp. 451-456.
Rubini, E., Chorev, M., Gilon, C., Friedman, Z.Y., Wormser,U. and Selinger, Z. (1981), Enzymatically Stable, Partially Modified Retro-Inverso Analogs of Substance P: Synthesis and Biological Activity. In: "Peptides - Synthesis - Structure - Function -  Proceedings of The 7th American Peptide Symposium" (Rich, D.H. And Gross, E., Eds.) Pierce Chemical Co., Rockford, Ill. pp. 593-597.
Wormser, U., Gilon, C., Chorev, M., Laufer, R. And Selinger, Z. (1984), Degradation of [pGlu6]Sp6-11 And its N-Methylated Analogs in Rat Hypothalamic and Parotid Slices. In: "Peptides 1984", U. Ragnarsson Ed. Almquist & Wiksell Int. Stockholm, Sweden pp. 351-354.
Rubini, E., Wormser, U., Levian-Teitelbaum, D., Laufer, R.,Gilon, C., Selinger, Z. and Chorev, M. (1985), Design, Synthesis and Biological Activity of Topologically Related Partial Non-Peptide Peptidomimetic Analogs of Substance P. In: Peptides Structure and Function, (Koppe K.D. and Deber C.M. Eds.) Pierce Chem. Comp.Rockland, Ill. pp. 635-638.
Chorev, M., Laufer, R., Ron, D., Frey, J., Wormser, U., Rubini, E., Selinger, Z. and Gilon, C. (1987), Design, Synthesis and Biological Activity of Selective Agonists for Tachykinin Receptor Subtypes. In: "Peptides 1986" (Theodoropolus, D. Ed.) Walter De Gruyter Co., Berlin, pp. 397-400.
Wormser, U. and Calp, D. (1988), Induction of Hepatic Metallothionein following Acetaminophen Administration. In: The Target Organ and the Toxic Process, Proceedings of The European Society of Toxicology, Arch. Toxicol., Suppl. 12, 375-377.
Wormser, U. and Calp, D. (1988), A Rapid and Reliable Acute Toxicity Test for Hepatotoxic Agents Using only A Single Animal. In: Alternative Methods In Toxicology, Progress in In Vitro Toxicology, (Goldberg, A.M. Ed.) Marry Ann Liebert Inc., N.Y. 6, 303-307.
Wormser, U. and Ben-Zakine, S. (1989), Protective Effect of Zinc against Hepatotoxic Agents in the Rat Liver Slice System: Role of Metallothionein. In: Biological Monitoring of Exposure and the Response at Subcellular Level to Toxic Substances. Arch. Toxicol., Suppl. 13, 316-318. (number of citations minus self citations 4)
Wormser, U., Ben-Zakine, S., Stivelband, E. and Nyska, A. (1989), The Liver Slice System: A Simple Acute Toxicity Test for Evaluation of Hepatotoxic Agents. In: Alternative Methods in Toxicology, In Vitro Toxicology - New Directions (Goldberg A.M. Ed.) Marry Ann Liebert Inc. N.Y. 7 231-236.
Wormser, U., Ben-Zakine, S. and Nyska, A. (1990) The Liver Slice System: A Rapid and Simple Acute Toxicity Test for Assessment of Environmental Toxic Substances. In: Proceedings of The Second International Conference on Environmental Analytical Chemistry, Honolulu, Hawaii. US Environmental Protection Agency, US National Institute of Standards and Technology, The Center for Environmental Health-Cornell University, pp. 108-114.
Wormser, U., Brodsky, B., Shatz, I., Furth, M., Ashash, E., Weisman, Y.and Nyska, A. (1997), A Bioassay for Evaluation of Exposure to Environmental Hazardous Agents. The ASA Newsletters, 58, 16-17.
Wormser, U., Yellin-Arad, R., Green B.S., Brodsky, B. and  Nyska, A. (1997), Post-Exposure Treatment with Povidone-Iodine Ointment Protects Guinea Pig Skin against Sulfur and Nitrogen Mustards. Proceedings of the Second Chemical and Biological Medical Treatment Symposium, Spiez, pp 146-148.
Wormser, U., Brodsky, B., Shatz, I., Furth, M., Ashash, E., Weisman, Y.and Nyska, A. (1997), A Bioassay for Evaluation of Exposure to Environmental Hazardous Agents. Proceedings of the Second Chemical and Biological Medical Treatment Symposium, Spiez, pp 149-150.
Wormser, U., Brodsky, B., Moor, E.V., Eldad, A., Gal, R., Nyska, A. and Kohen, R. (1998), Skin Surface Proteolytic Activity: Partial Characterization and Identification. Adv. Exp. Med. Biol. 436, 207-212.
Wormser, U., Brodsky,B., Nyska, A. and Sintov, A. (2000), Iodine protects against sulfur mustard-induced skin lesions. US Army Medical Defense Bioscience Review, Biosience 2000 Proceedings, 522-528.
Brodsky, B., Wormser, U., Nyska, A. and Sintov, A. Topical treatment with iodine reduces skin toxicity caused by sulfur mustard. Proceedings of the CBMTS III Symposium, Spiez, Switzerland.
Wormser, U., Sintov, A.,  Brodsky, B., Casillas, R.P. and Nyska, A. protective effect of new povidone-iodine preparation against sulfur mustard-induced skin lesions. US Army Medical Defense Bioscience Review, Biosience 2002.
Wormser U, Langenbach R, Peddada S, Sintov A, Brodsky B and Nyska A. Involvement of Cyclooxygenase in Sulfur Mustard Toxicity. US Army medical Defense Review Bioscience, 2004 Proceedings.
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Wormser, U. (1991) A Neutralizing Agent for Mustard Gas. Patent Application No. 095087.
Wormser, U. and Sintov, A. (1997) Transdermal Delivery System. Israeli Patent Application No. 120,943; International Application No. PCT/ IL 98/ 00205 (1998); PCT WO98/53847; US Pat. No. 6,274,166 B1; Continuation in Part Application No. 09/928,131 (2001). US Patent No. 6,667,052 B2 (2003), European patent No.  0975357.
Wormser, U. (1998) Protective Factor against Burns. US Patent Application No. 60-086,606, refilled 60-153,990 (1999).
Wormser, U. and Sintov A. (2000) Compositions containing molecular iodine. Israeli Patent Application No. 135,222; International Application No. PCT/ IL 01/00277 (2001). European patent No. 1280538 B1. Singapore patent No. 91731. US Patent  No. 6,926,913 B2
Wormser, U. (2001) Protective factors against inflammation, burns and noxious stimuli. Israeli Application No. 145,181; PCT Patent Application No. PCT/IL02/00713 (2002).
Wormser, U. Histone H2A peptide derivatives and methods of use thereof. US Patent Application 60/555,334 (2004); PCT Patent Application No. PCT/IL2005/000328 (2005).
Sintov, A., Ben Shabat, S. and Wormser, U. Topical systems based on complexes of vitamin D derivatives and fatty acids and thereof. US Patent Application 60/566,401, (2004); PCT/IL05000405 (2005).
Wormser, U. Cosmetic preparation comprising short peptides. US Provisional Application 60/715,589 (2005).
Wormser, U. Peptides derived from alfa-1 antitrypsin and methods of use thereof. US provisional application. 61/121,203 (2008).
Wormser, U.  Peptides derived from oryza sativa japonica group and uses thereof. US provisional application 61/177,353 (2009).
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