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Researchers
  • Prof.  Yechiel Friedlander
Prof Yechiel Friedlander
 
Research fields
 
·       Biostatistics & Epidemiology
·       Cardiovascular Health & Disease
·       Genetic Epidemiology
·       Nutrition, Metabolism & Obesity
 
 
Research and Professional Activity
 
Genetic epidemiology of cardiovascular disease
Genetic epidemiology of cardiovascular risk factors
Perinatal Epidemiology and its relation to chronic diseases and mortality
 
 
Collaborations
 
Department of Epidemiology (CHRU), University of Washington, Seattle
National University of Singapore
Framingham Study
 
 
Teaching
 
Survey and Research Methods in Public Health
Statistical methods of Rates and Risk measures
Genetic epidemiology
Survival analysis
Clinical trials
 
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Selected Publications 
Friedlander Y, Cohen T, Stenhouse N, Davies AM, Stein Y. Familial aggregation of total cholesterol, triglyceride and high-density lipoprotein cholesterol in an Israeli population sample. Israel J Med Sci, 18:1137-1143, 1982.
 
Friedlander Y, Kark JD, Eisenberg S, Stein Y: Calculation of LDL-cholesterol from  total cholesterol, triglyceride and HDL-cholesterol: A comparison of methods in the Jerusalem Lipid Research Clinic prevalence Study. Israel J Med Sci, 18:1242-1252, 1982.
 
Karlin S, Carmelli D, Friedlander Y, Williams PT, Cohen T, Stein Y: Association arrays for comparing familial total cholesterol, high-density-lipoprotein cholesterol and triglyceride similarity in the Israeli population by country of origin. Am J Epidemiol,116:1022-1032, 1982.
 
Friedlander Y, Kark JD, Cohen T, Eisenberg S, Stein Y: Admixture analysis of high density lipoprotein cholesterol distribution in a Jerusalem population sample. Clin  Genet, 24:117-127, 1983.
 
Friedlander Y, Kark JD, Cohen T, Eisenberg S, Stein Y: Admixture analysis of plasma cholesterol levels in a Jewish population sample in Jerusalem. Human Heredity, 34:82-95, 1984.
 
Friedlander Y, Kark JD, Fainaru M, Gotsman M, Stein Y:  Aggregation of plasma lipids and lipoproteins in families with and without coronary heart disease. Atherosclerosis,  57:235-247, 1985.
 
Friedlander Y, Kark JD: Familial aggregation of blood pressure in a Jewish       population sample in Jerusalem among ethnic and religious groupings. Social Biology, 31:75-90, 1985.
 
Friedlander Y, Kark JD, Stein Y: Variability of plasma lipids and lipoproteins. The Jerusalem Lipid Research Clinic Study. Clinical Chemistry, 31:1121-1126, 1985.
 
Friedlander Y, Kark JD, Stein Y: Family history of myocardial infarction as an        independent risk factor for coronary heart disease. British Heart Journal, 53:382-387,1985.
 
Friedlander Y, Kark JD, Kaufmann NA, Stein Y: Coronary heart disease risk factors among religious groupings in a Jewish population sample in Jerusalem. Am J Clinical Nutrition, 42 (3):511-521, 1985.
 
Friedlander Y, Kark JD, Stein Y. Religiosity and myocardial infarction inJerusalem: a case-control study. International Journal Cardiol, 10:33-41, 1986.
 
Friedlander Y. Religiosity and myocardial infarction in Jerusalem. Letter to the editor.  Int Journal Cardiol, 12:270-271, 1986.
 
Friedlander Y, Kark JD, Stein Y. Heterogeneity in multifactorial inheritance of        plasma lipids and lipoproteins in ethnically diverse families in Jerusalem. Genet Epidemiol, 3:95-112, 1986.
 
Friedlander Y, Kark JD, Stein Y. Biological and Environmental sources of variation in plasma lipids and lipoproteins:The Jerusalem Lipid Research Clinic. Human Hered,  36:143-153, 1986.
 
Friedlander Y, Kark JD, Stein Y. Complex segregation analysis of low levels of        plasma high density lipoprotein cholesterol in a Jerusalem sample of nuclear families.  Genet Epidemiol, 3:285-297, 1986.
 
Friedlander Y, Kark JD. Complex segregation analysis of plasma lipid and lipoprotein  variables in a Jerusalem sample of nuclear families. Human Hered, 37:7-19, 1987.
 
Friedlander Y, Kark JD, Stein Y. Religious observance and plasma lipids and        lipoproteins among 17-year old Jewish residents of Jerusalem. Preventive Medicine, 16:70-79, 1987.
 
Friedlander Y, Kark JD. Religiosity and myocardial infarction in Jerusalem. Letter  to the editor. Journal Cardiol, 16:322-323, 1987.
 
Friedlander Y, Bucher K, Eisenberg S, Heiss G, Kark JD, Namboodiri KK, Stein Y, Tyroler HA. Heterogeneity between selected populations in the United States and Israel for familial aggregation of plasma lipids. Am J Epidemiol, 126:268-279, 1987.
 
Friedlander Y, Kark JD, Bar-On H. Family resemblance for fasting blood glucose: The Jerusalem Lipid Research Clinic. Clinical Genetics, 32:222-234, 1987.
 
Friedlander Y, Kark JD, Stein Y. Biological and environmental sources of familial aggregation of blood pressure: The Jerusalem Lipid Research Clinic. Int J Epidemiol, 17:70-75, 1988.
 
Bucher KD, Friedlander Y, Kaplan EB, Namboodiri KK, Kark  JD, Eisenberg S, Stein Y, Rifkind BM. Biological and cultural familial resemblances of plasma lipids:  A comparison between selected populations in North America and Israel. The Lipid  Research Clinics Program. Genet Epidemiol, 5:17-34, 1988.
 
Friedlander Y, Kark JD, Kaufmann NA, Berry E, Stein Y. Familial associations of  Weight and Body Mass index in ethnically diverse families in Jerusalem. The Jerusalem  Lipid Research Clinic. Int J Obesity, 12:237-247,1988.
 
Friedlander Y, Kark JD, Stein Y. Familial resemblance for serum uric acid in aJerusalem sample of families: The Jerusalem Lipid Research Clinic. Human Genetics, 79:58-63, 1988.
 
Friedlander Y, Palti H, Adler B. Temporal trends in sibling correlations for height  and weight. Hum Biol, 61:271-286, 1989.
 
Oppenheim A, Friedlander Y, Dan EJ, Schwartz SP, Leitersdorf E. Familial        hypercholesterolemia in five Israeli Christian-Arab kindreds: Complex segregation and  linkage analysis of lipid and lipoprotein variables. Human Genet, 88:75-84, 1991.
 
Friedlander Y, Dann EJ, Leitersdorf E. Absence of familial defective apolipoprotein  B-100 in Israeli patients with dominantly inherited hypercholesterolemia and in  offspring with parental history of myocardial infarction. Hum Genet, 91:299-300, 1993.
 
Friedlander Y, Lev Merom D, Kark JD. A comparison of different matching designs  in case-control studies: An empirical example using continuous exposures, continuous  confounders and incidence of myocardial infarction. Stat in Med, 12:993-1004, 1993.
 
Friedlander Y, Kaufmann NA, Cedar H, Weinberg N, Kark JD. The role of XbaI polymorphism of the apolipoprotein B gene in determining levels and covariability of lipids and lipoprotein variables in a sample of Israeli offspring with family history of myocardial infarction. Atherosclerosis, 98:165-177, 1993.
 
Friedlander Y, Kaufmann NA, Cedar H, Kark JD. XbaI polymorphism of the apolipoprotein B gene and plasma lipid and lipoprotein response to dietary fat and cholesterol: a clinical trial. Clin Genet, 43:223-231, 1993.
 
Friedlander Y, Kark JD, Kidron M, Bar-On H. Univariate and bivariate admixture analyses of serum glucose and glycosylated hemoglobin distributions in a Jerusalem  population. Human Biology, 67(1): 151-170, 1995.
 
Friedlander Y, Berry E, Eisenberg S, Stein Y, Leitersdorf E. Plasma lipids and lipoproteins response to a dietary challenge: analysis of four candidate genes. Clin Genet, 47:1-12, 1995.
 
Friedlander Y. Sibling correlations for coronary heart disease risk factors in a sample of Israeli offspring with family history of myocardial infarction. Atherosclerosis, 113:259-271, 1995.
 
Friedlander Y, Leitersdorf E. Segregation analysis of plasma lipoprotein(a) levels in pedigrees with molecularly defined familial hypercholesterolemia. Genet Epidemol, 12:129-143, 1995.
 
Friedlander Y, Elkana Y, Sinnreich R, Kark JD. Genetic and environmental sources  of fibrinogen variability in Israeli families: The Kibbutzim Family Study. Am J Hum Genet, 56:1194-1206, 1995.
 
Friedlander Y, Leitersdorf E. Apolipoprotein E genotype influence on the outcome of segregation analysis of plasma lipid and lipoprotein levels in pedigrees with molecularly defined familial hypercholesterolemia. Genet Epidemol, 13:159-177, 1996.
 
Friedlander Y. Genetic Contributions to LDL-C, ApoB and LDL-C/ApoB Ratio in a sample of Israeli offspring with parental history of myocardial infarction. Clin Genet, 50:1-9, 1996.
 
Austin M, Friedlander Y, Newman B, Selby JV, Edwards K, Mayer E, King M-C. Genetic influences on changes in body mass index: A longitudinal analysis of women twins. Obesity Research, 5:326-331, 1997.
 
Friedlander Y, Austin M, Newman B, Edwards K, Mayer E, King M-C. Genetic influences on longitudinal changes in coronary heart disease risk factors: The Kaiser Permanente Women Twins Study. Am J Hum Genet, 60:1502-1512, 1997.
 
Friedlander Y, Siscovick DS, Weinmann S, Austin MA, Psaty BM, Lemaitre RN, Arbogast P, Raghunathan TE, Cobb LA. Family history as a risk factor for primary cardiac arrest, Circulation 97:155-160, 1998.
 
Sinnreich R, Kark JD, Friedlander Y, Sapoznikov D, Luria MH. Heart rate variability measures for population studies: sex and age differences in para-sympathetic- sympathetic balance in Israeli kibbutzim. Heart, 80:156-162, 1998.
 
Sinnreich R, Friedlander Y, Sapoznikov D, Kark JD. Familial aggregation of heart rate variability based on short recordings: the kibbutzim family study. Hum Genet, 103:34-40, 1998.
 
Friedlander Y, Kark JD, Sinnreich R, Edwards KL, Austin MA. Inheritance of LDL peak particle diameter: results from a segregation analysis in Israeli families, Genetic Epidemiol, 16:382-396, 1999.
 
Friedlander Y, Lapidos T, Sinnreich R, Kark JD. Genetic and environmental    Sources  of QT interval variability in Israeli families: The Kibbutz Settlements Family Study. Clinical Genet, 56:200-209, 1999.
 
Friedlander Y, Kidron M, Caslake M, Lamb T, McConnell M, Bar-On H. LDL particle size and risk factors of insulin resistance syndrome. Atheriosclerosis,  148:141-149, 2000.
 
Friedlander Y, Austin MA, Edward K, Talmud P, Hamphries S. Sib-Pair Linkage analysis of Candidate Genes and Longitudinal Changes in Coronary Heart Disease Risk Factors in Women Twins. J Lipid Res, 41:1302-1309, 2000.
 
Friedlander Y, Leitersdorf E, Vecsler R, Funke H, Kark JD. The Contribution of Candidate Genes to the Response of  Plasma Lipids and Lipoproteinsto Dietary Challenge. Atherosclerosis, 152:239-248, 2000.
 
Friedlander Y, Arbogast P, Schwartz SM,  Marcovina SM, Austin MA, Rosendaal FR, Reiner AP, Psaty BM, Siscovick DS. Family history as a risk factor for early myocardial infarction in women.  Atherosclerosis, 156:201-207, 2001.
 
Friedlander Y, Siscovick DS, Weinmann S, Austin MA, Psaty BM, Lemaitre RN, Arbogast P, Raghunathan TE, Cobb LA. Sudden death and myocardial infarction in first-degree relatives as predictors of primary cardiac arrest. Atherosclerosis, 162:211-216, 2002.
 
Friedlander Y,  Paltiel O, Deutsch L,  Knaanie A,  Masalha S,  Tiram E,  Harlap S. Birth-Weight and Mortality in the Jerusalem Perinatal Study.  Paediatric and Perinatal Epidemiology, 17:398-406, 2003.
 
Friedlander Y,  Kark JD, Sinnreich R, Basso F, Humphries SE. Combined Segregation and Linkage Analysis of Fibrinogen Variability in Israeli Families: Evidence for Two Quantitative-Trait Loci, One of Which is Linked to a Functional Variant (-58G>A) in the Promoter of the a-Fibrinogen Gene. Ann of Hum Genet, 67:228-241, 2003.
 
Friedlander Y, Vatta M,  Sotoodehnia N,  Sinnreich R,  Li H, Manor O, Towbin JA, Siscovick DS, Kark JD. Possible Association of the human KCNE1 (minK) gene and QT Interval in Healthy Subjects: Evidence from Association and Linkage Analyses in Israeli families. Ann of Hum Genet, 69:645-656, 2005.
 
Friedlander Y, Kark JD, Sinnreich R, Tracy R, Siscovick DS. Fibrinogen and CRP in Israeli Families: Genetic and Environmental Sources of Concentrations and Longitudinal Changes. Atherosclerosis 189:169-177, 2006.
 
Harlap S, Deutch L, Manor O,  Paltiel O, Perrin MC, Terry MB, Tiram E, Yanetz R, Malaspina D, Friedlander Y. A REVIEW OF THE JERUSALEM PERINATAL STUDY. Paediatr Perinat Epidemiol, 2007; 21:256-273.
 
Friedlander Y, Paltiel O, Manor O, Deutsch L, Yanetz R, Calderon R, Siscovick DS, Harlap S. Birthweight of Offspring and Mortality of Parents: The Jerusalem Perinatal Study Cohort. Annals of Epidemiology, 17:914-922, 2007.
 
Friedlander Y, Schwartz SM, Durst R, Meiner V, Robertson AS, Leitersdorf E, Siscovick DS. SREBF2 and SCAP Polymorphisms and Risk of Early Onset Myocardial Infarction. Atherosclerosis, 196:896-904 2008.
 
Rozenn N. Lemaitre, David S. Siscovick, Elliot M Berry, Jeremy D Kark, Yechiel Friedlander Familial Aggregation of Red Blood Cell Membrane Fatty Acid Composition - the Kibbutzim Family Study. Metabolism, 57:662-668,2008.
 
Paltiel O, Yanetz R, Calderon-Margalit R, Manor O, Sharon N, Harlap S, Friedlander Y, Very high birth weight of offspring is associated with an increased risk of leukemia in their mothers; results of a population-based cohort study. Leukemia Research  2008;32:1709-1714.
 
Meiner V, Friedlander Y, Milo H, Sharon N, Ben-Avi L, Shpitzen S, Leitersdorf E, Siscovick DS, Schwartz SM. Cholestryl Ester transfer Protein (CETP) Genetic Variation and Early Onset of Non-Fatal Myocardial Infarction. Ann Hum Genet 2008;72:732-741.
 
Calderon-Margalit R, Friedlander Y, Yanetz R, Deutsch L, Perrin MC,  Kleinhaus K, Tiram E, Harlap S, Paltiel O. Preeclampsia and subsequent risk of cancer: update from the Jerusalem Perinatal Study. Am J Obst Gynecol 2009; 200:63e1-63e5.
 
Friedlander Y, Manor O, Paltiel O, Meiner V, Sharon N, Calderon R, Hochner H, Sagy Y, Avgil M, Harlap S, Siscovick DS. Birthweight of Offspring, Maternal Pre-pregnancy Characteristics and Mortality of Mothers:  The Jerusalem Perinatal Study Cohort. Ann of Epidemiol 2009;19:112-117.
 
Friedlander Y, Meiner V, Sharon N, Siscovick DS, Miserez AR. Leptin, insulin and obesity - phenotypes: Genetic influences on levels and longitudinal changes. Obesity 2009;17:1458-1460.
 
The Emerging Risk Factors Collaboration: Lipoprotein (a) concentration and the risk of coronary heart disease, stroke and nonvascular mortality. Individual data analysis of 121,944 participants from 34 cohorts. JAMA 2009;302:412-423.
 
Kathiresan S, Voight BF, Purcell S, Musunuru K, Ardissino D, Mannucci PM, Anand S, Engert JC, Samani NJ, Schunkert H, Erdmann J, Reilly MP, Rader DJ, Morgan T, Spertus JA, Stoll M, Girelli D, McKeown PP, Patterson CC, Siscovick DS, O'Donnell CJ, Elosua R, Peltonen L, Salomaa V, Schwartz SM, Melander O, Altshuler D, Merlini PA, Berzuini C, Bernardinelli L, Peyvandi F, Tubaro M, Celli P, Ferrario M, Fetiveau R, Marziliano N, Casari G, Galli M, Ribichini F, Rossi M, Bernardi F, Zonzin P, Piazza A, Yee J, Friedlander Y, Marrugat J, Lucas G, Subirana I, Sala J, Ramos R, Meigs JB, Williams G, Nathan DM, MacRae CA, Havulinna AS, Berglund G, Hirschhorn JN, Asselta R, Duga S, Spreafico M, Daly MJ, Nemesh J, Korn JM, McCarroll SA, Surti A, Guiducci C, Gianniny L, Mirel D, Parkin M, Burtt N, Gabriel SB, Thompson JR, Braund PS, Wright BJ, Balmforth AJ, Ball SG, Hall AS, Linsel-Nitschke P, Lieb W, Ziegler A, König I, Hengstenberg C, Fischer M, Stark K, Grosshennig A, Preuss M, Wichmann HE, Schreiber S, Ouwehand W, Deloukas P, Scholz M, Cambien F, Li M, Chen Z, Wilensky R, Matthai W, Qasim A, Hakonarson HH, Devaney J, Burnett MS, Pichard AD, Kent KM, Satler L, Lindsay JM, Waksman R, Epstein SE, Scheffold T, Berger K, Huge A, Martinelli N, Olivieri O, Corrocher R, McKeown P, Erdmann E, König IR, Hólm H, Thorleifsson G, Thorsteinsdottir U, Stefansson K, Do R, Xie C, Siscovick D. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nature Genetics 2009;41:334-341.
 
The Emerging Risk Factors Collaboration: C-reactive protein concentration and the risk of coronary heart disease. Collaborative analysis on data of 160,309 participants from 54 cohorts. Lancet,  2009;375:132-140.
 
The Emerging Risk Factors Collaboration: Major lipids, apolipoproteins and the risk of vascular disease. JAMA 2009;302:412-423.
 
Lemaitre RN, King IB, Sotoodehnia N, Knopp RH, Mozaffarian D, McKnight B, Rea TD, Rice K, Friedlander Y, Lumley TS, Raghunathan TE, Copass MK, Siscovick DS. Endogenous red blood cell membrane fatty acids and sudden cardiac arrest  Metabolism, 2010; 59:1029-1034
 
The Emerging Risk Factors Collaboration: Diabetes, fasting glucose and risk of vascular disease: collaborative analysis of 96 prospective studies. Lancet, 2010; 375:2216-2222.
 
The Emerging Risk Factors Collaboration: Triglyceride-mediated pathways and coronary disease: A genetic evidence for causal association. Lancet, 2010; 375:1634-1639.
 
The Emerging Risk Factors Collaboration: Statistical methods for the time-to-event analysis of individual participant data from multiple epidemiologic studies.  Int J Epidemiol, 2010; 39:1345-1359.
 
Friedlander Y, Li G, Fornage M, Williams OD, Lewis CE, Schreiner P, Pletcher MJ, Enquobahrie D, Williams M ,Siscovick DS.Candidate Genes from Molecular Pathways Related to Appetite Regulatory Neural Network and Adipocyte Homeostasis and Obesity: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Ann Hum Genet, 2010; 74:387-398.
 
Erez G, Tirosh A, Rudich A, Meiner V, Schwarzfuchs D, Sharon N, Shpitzen S,  Blüher M, Stumvoll M, Thiery J, Fiedler GM, Friedlander Y, Leiterstdorf E, Shai I. Phenotypic and genetic variation in leptin as determinants of weight regain over a 2 year nutritional intervention study Int J Obes, 2011; 35:785-792
 
The Emerging Risk Factors Collaboration: Diabetes mellitus, fasting glucose and risk of cause-specific mortality. NEJM, 2011; 364:829-841.
 
Lemaitre NL, Tanaka T, Tang W, Manichaikul A,  Foy M, Kabagambe E, Nettleton JA, King IB, Weng L-C, Bhattacharya S, Bandinelli S, Bis J, Rich SS, Jacobs DR Jr, Cherubini A, McKnight B, Liang S, Gu X, Rice K, Laurie CC, Lumley T, Browning BL, Psaty BM, Friedlander Y, Djousse L, Hu J, Siscovick DS, Uitterlinden AG, Arnett DK, Ferrucci L, Fornage M, Tsai MY, Mozaffarian D, Steffen LM. Genetic Loci Associated with Plasma Phospholipid n-3 Fatty Acids: A Meta-Analysis of Genome-wide Association Studies from the CHARGE Consortium. PLOS Genetics, Jul 2011; 7(7):e1002193.
 
Avgil-Tsadok M, Friedlander Y, Paltiel O, Manor O, Meiner V, Hochner H, Sagy Y, Sharon N, Yazdgerdi S, Siscovick DS, Elchalal U. Obesity and blood pressure in 17 year old offspring of mothers with gestational diabetes: insights from the Jerusalem Perinatal Study (JPS). Experimental Diabetes Research, 2011; 2011:906154.
 
Rapsomaniki E, White IR,Wood AM, Simon G. Thompsonb,c, et al. The Emerging Risk Factors Collaboration A framework for quantifying net benefits of alternative prognostic models. Stat in Med 2011.
 
Toperoff G, Aran D, Kark JD, Rosenberg M, Dubnikov T, Nissan B,Wainstein J, Friedlander Y, Levy-Lahad E, Glaser B, Hellman A. Genome-wide survey reveals predisposing diabetes type 2-related DNA methylation variations in human peripheral blood. Hum Mol Genet,  2012;21:371-383.
 
  
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