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  • Prof.  Elka Touitou
Prof Elka Touitou
Research Interests 
            ·       Dermal and transdermal drug delivery: enhancers and mechanism of action, enhanced delivery of peptides and other drugs
                   through biological membranes
            ·       Nasal drug delivery for systemic action
            ·       New CNS therapies
            ·       Systems for prevention and regeneration of burn injury
            ·       Novel approaches for  enhanced and modulated  delivery  of peptides  and drugs to/through the skin: ethosomes, eutectics,
                   chiral drugs
            ·       Novel combined model for skin penetration with biological endpoint
            ·       Design and development of a new sunscreen non-penetrating the skin
Research Projects  
Ethosomes: novel vesicular carriers for topical and transdermal delivery
Carriers for enhanced nasal absorption of therapeutic agents
Specially tailored carriers for topical anti-cancer therapy
Improved delivery of testosterone from novel transdermal systems: testosome patch and gel
New dermal therapeutic compositions for treatment of: acne, deep skin infections, alopecia, herpes simplex, cellulite
New transdermal delivery systems for treatment of: hypogonadism, erectile dysfunction, pain, inflammation, depression, rheumatic arthritis
New sanitizer concept and compositions
Books edited 
Touitou E., Barry B.W. (Eds.), Enhancement in Drug Delivery, CRC Press, Taylor & Francis Group, Boca Raton-London-New York, 2006
Magdassi S., Touitou E. (Eds.), Novel Cosmetic Delivery Systems, Marcel Dekker, Inc., New York, 1999
Book Chapters:
Godin B and Touitou E. Dermal and transdermal delivery. In: Bhushan B. and Decuzzi P. (Eds.) Encyclopedia of nanotechnology, Springer, Invited, 2012, In press.
Ainbinder D., Touitou E., Skin photodamage prevention: state of the art and new prospects, In: Farage M.A., Miller K. W., Maibach H. I. (Eds) Textbook of Aging Skin, Springer-Verlag Berlin Heidelberg, 2010, DOI 10.1007/978-3-540-89656-2 44.
Godin B., Touitou E., Nanoparticles aiming at specific targets - dermal and transdermal delivery, In: Domb A. J., Tabata Y., Ravi Kumar M. N. V. (Eds) Nanoparticles for Pharmaceutical Applications, American Scientific Publishers, Valencia, 2007, pp. 192-211.
Godin B., Touitou E., Surfactants in enhanced enteral delivery of macromolecules, In: Touitou E., Barry BW. (Eds) Enhancement in drug delivery, CRC Press, Taylor & Francis Group, Boca Raton-London-New York, 2006, pp. 37-56.
Touitou E., Godin B., Vesicles for enhanced delivery into and through the skin, In: Touitou E., Barry BW. (Eds) Enhancement in drug delivery, CRC Press, Taylor & Francis Group, Boca Raton-London-New York, 2006, pp. 255-278.
Touitou, E., Godin, B., Enhanced skin permeation using ethosomes, In: Smith and Maibach (Eds) Percutaneous Penetration Enhancers, 2nd edition, CRC Press, New York, 2005, pp 95-108.
Touitou, E., Godin, B., Kommuru, T.R, Afouna, M.I., Reddy I.K., Transport of chiral molecules across the skin, In: Reddy and Mehvar (Eds) Chirality in drug design and development, Marcel Dekker, Inc., New York, 2003, pp. 67-99.
Magdassi, S., Touitou, E., Cosmeceutics and Delivery Systems, In: Magdassi and Touitou (Eds) Novel Cosmetic Delivery Systems, Marcel Dekker, Inc., New York, 1999, pp.1-9.
Meidan, V.M., Touitou, E., Quantitation of penetrant molecules within the skin, In: Novel Cosmetic Delivery Systems, Marcel Dekker, Inc., New York, 1999, pp. 131-144.
Touitou, E., Chow, D.D., n-Decyl Methyl Sulphoxide, In: Maibach and Smith (Eds) Skin Permeation Enhancers, CRC, New York, 1995, pp.103-113.
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Touitou, E. Compositions for applying active substances to or through the skin
Touitou, E. Compositions and methods for intracellular delivery
Touitou, E., Bergelson, L. Products for preventing penetration into the skin
Touitou, E., Godin, B. In vitro test for predicting pharmacologic and/or pharmacokinetic and/or pharmacodynamic parameters of a compound
Touitou E. Method and composition for burned skin
Touitou E., Godin B., Duchi S. Compositions for nasal delivery
Formulations and testing of dermal and transdermal products
Methods for quantitating drugs in the skin
Novel and generic dermal formulations
Use of ethosomes for design of topical and transdermal formulations of peptides, antivirals, antialopecia, others
Design of new carriers for topical compositions
Novel model for skin penetration and bioassay for Pharmalogica consortium, Magnet, Ministry of Industry, Israel
The Pharmaceutical Society of Israel Honorary Award 2011
Best teacher of the year 2009
Kaye Award for Innovation (2006)
Jorge Heller 2000 JCR Outstanding Paper Award
Outstanding Paper Award – Drug Delivery to the 3rd Millennium Conference -Italy (1999)
Honoree Women Pharmacist of the World (FIP 1998)
Professional Activities:
Reviewer of Scientific International Journals 
Reviewer for International Institutional Grants:
Italian Ministry of Research and Universities
Arthritis Research Campaign (UK)
Research Founds Committee (FWF, Austria)
Ministry of Health (Israel)
Ministry of Agriculture (Israel)
Ministry of Science (Israel)
Binational Science Foundation (Israel-US)
ISF (Israel)
Public Responsibilities and Committees:
Public Representative, Appointment Committee (Ministry of Health)
Member of the Advisory Committee to the Ministry of Health for Cosmetic products registration, Israel
Skin Bioavalability Committee (Ministry of Health)
Adviser Committee for Curriculum (ORT Givat-Ram High School, Jerusalem Municipality)
Committee for updating the Pharmaceutical Law, Ministry of Heath
 Professional Honors:
CRS Fellow from 2010
Member at Large, Board of Directors, CRS
President – Israeli Chapter of CRS (ICRS)
Member of Awards Committee, CRS
Board - Israeli Chapter of CRS (ICRS)
Relevant Publications 
Ainbinder D, Touitou E. A new approach for skin tumor treatment: from delivery system characterization to in vivo evaluation
Drug Deliv. Transl. Res., 1(1): 53-65, 2011
Ainbinder D, Paolino D, Fresta M, Touitou E. Drug Delivery Applications with Ethosomes. J. Biomed. Nanotechnol., 6(5): 558–568, 2010
Shumilov M, Bercovich R, Duchi S, Ainbinder D, Touitou E. Ibuprofen Transdermal Ethosomal Gel: Characterization and Efficiency in Animal Models. J. Biomed. Nanotechnol., 6(5): 569-576, 2010
Shumilov M, Touitou E. Buspirone transdermal administration for menopausal syndromes, in vitro and in animal model studies
Int. J. Pharm., 387(1-2): 26-33, 2010
Ainbinder D, Protokin R, Chaouat M, Touitou E., Effect of honokiol and 5-FU on non-melanoma skin cancer cells, J. Drug Del. Sci. Tech., 19 (4): 283-7, 2009
Shumilov M, Touitou E, Godin B, Ainbinder D, Yosha I, Tsahor-Ohayon H., Evaluation of a polysiloxane-collagen biphasic membrane: a model for in vitro skin permeation studies, J. Drug Del. Sci. Tech., 19 (4): 289-94, 2009
Touitou E, Godin B, Shumilov M, Bishouty N, Ainbinder D, Shouval R, Ingber A, Leibovici V., Efficacy and tolerability of clindamycin phosphate and salicylic acid gel in the treatment of mild to moderate acne vulgaris, J. Eur. Acad. Dermatol. Venereol. 22 (5): 629-31, 2008
Touitou E, Godin B., Skin nonpenetrating sunscreens for cosmetic and pharmaceutical formulations, Clin. Dermatol. 26 (4): 375-9, 2008
Godin B, Touitou E., Transdermal skin delivery: predictions for humans from in vivo, ex vivo and animal models, Adv. Drug Deliv. Rev. 59 (11): 1152-61, 2007
Touitou E, Waknine JH, Godin B, Golenser J., Treatment of malaria in a mouse model by intranasal drug administration, Int. J. Parasitol. 36 (14): 1493-8, 2006
Ainbinder D, Touitou E., Testosterone ethosomes for enhanced transdermal delivery, Drug. Deliv. 12 (5): 297-303, 2005
Godin B, Touitou E, Rubinstein E, Athamna A, Athamna M., A new approach for treatment of deep skin infections by an ethosomal antibiotic preparation: an in vivo study, J. Antimicrob. Chemother. 55 (6): 989-94, 2005
Godin B, Touitou E., Erythromycin ethosomal systems: physicochemical characterization and enhanced antibacterial activity, Curr. Drug Deliv. 2 (3): 269-75, 2005
Godin B, Touitou E., Mechanism of bacitracin permeation enhancement through the skin and cellular membranes from an ethosomal carrier, J. Control Release. 94 (2-3): 365-79, 2004
Touitou E, Lodzki M, Godin B, Rakou L, Mechoulam R, Gallily R., Cannabidiol-transdermal delivery and anti-inflammatory effect in a murine model, J. Control Release. 93 (3): 377-87, 2003
Godin B, Touitou E., Ethosomes: new prospects in transdermal delivery, Crit. Rev. Ther. Drug Carrier Syst. 20 (1): 63-102, 2003
Touitou E., Drug delivery across the skin, Expert Opin. Biol. Ther. 2 (7): 723-33, 2002
Touitou E, Godin B, Karl Y, Bujanover S, Becker Y., Oleic acid, a skin penetration enhancer, affects Langerhans cells and corneocytes, J. Control Release. 80 (1-3): 1-7, 2002
Touitou E, Godin B, Dayan N, Weiss C, Piliponsky A, Levi-Schaffer F., Intracellular delivery mediated by an ethosomal carrier, Biomaterials 22 (22): 3053-9, 2001
Evrard D, Touitou E, Kolusheva S, Fishov Y, Jelinek R., A new colorimetric assay for studying and rapid screening of membrane penetration enhancers, Pharm. Res. 18 (7): 943-9, 2001
Meidan VM, Touitou E., Treatments for androgenetic alopecia and alopecia areata: current options and future prospects, Drugs 61 (1): 53-69, 2001
Dayan N, Touitou E., Carriers for skin delivery of trihexyphenidyl HCl: ethosomes vs. liposomes, Biomaterials 21 (18): 1879-85, 2000
Touitou E, Dayan N, Bergelson L, Godin B, Eliaz M., Ethosomes - novel vesicular carriers for enhanced delivery: characterization and skin penetration properties, J. Control Release 65 (3): 403-18, 2000
Levi-Schaffer F, Slovik D, Armetti L, Pickholtz D, Touitou E., Activation and inhibition of mast cells degranulation affect their morphometric parameters, Life Sci. 66 (21): 283-90, 2000
Horwitz E, Pisanty S, Czerninski R, Helser M, Eliav E, Touitou E., A clinical evaluation of a novel liposomal carrier for acyclovir in the topical treatment of recurrent herpes labialis, Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 87 (6): 700-5, 1999
Touitou E, Meidan VM, Horwitz E., Methods for quantitative determination of drug localized in the skin, J Control Release 56 (1-3): 7-21, 1998 
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