Scientific Interest
· Drug delivery and therapy in cardiovascular disorders.
· Controlled release implantable and injectable drug delivery systems.
· Dosage forms and formulations.
· Targeted nanoparticles (polymeric-based and liposomes) in cancer and cardiovascular disorders.
· Gene, antisense, siRNA and protein delivery and therapy.
· Nanoparticles, Nanospheres, Liposomes, Matrices, Bisphosphonates.
· Modulation of the Innate Immunity (monocytes, macrophages).
Research Projects
· Anti-inflammatory Effects by Nanoparticles of Bisphosphonates Affecting Monocytes and Macrophages.
· Targeted Nanoparticles of Antisenses and siRNA in Mammary Carcinoma.
· Imunomodulation of the Innate-immunity by Liposomal Delivery Systems for Endometriosis Therapy.
· Blood Brain Barrier Transport of Nanoparticles.
· Nanoparticles (polymeric-based and liposomes) for MRI and Luminescence Imaging
· The Role of Innate-immunity in Restenosis and MI.
Laboratory Techniques
Pharmaceutical formulations and compositions; dosage forms; dissolution and release kinetics; controlled / sustained release; animal models of restenosis and cancer; DSC/TG.
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Chapters in Books
- R.J. Levy, G. Golomb and R. Langer, Prevention of cardiovascular calcification with controlled-release diphosphonate. In: Artificial Organs, Proceedings of the International Symposium on Artificial Organs, Biomedical Engineering and Transplantation, J.D. Andrade, Ed., VCH Publishers, New York, 1987, pp. 657-669.
- R.J. Levy, T.P. Johnston, A. Sintov and G. Golomb, Controlled release implants for cardiovascular disease. In: Advances in Drug Delivery Systems, J.M. Anderson, S.W. Kim and K. Knutson, Eds., Elsevier Science Publications, Amsterdam, 1990, pp. 245-255.
- R.J. Levy, S.F. Bolling, R. Siden, A. Kadish, Y. Patak, P. Dorostkar, A. Sintov, G. Golomb and T.P. Johnston, Polymeric controlled release of cardiovascular drugs. In: Cosmetic and Pharmaceutic Polymer Applications, C. Gebelein, T.C. Cheng and V.C. Yang, Eds., Plenum Press, NY, 1991, pp. 231-238.
- R.J. Levy, G. Golomb, V. Labhasetwar, New frontiers in cardiovascular polymeric controlled release. Polymeric Materials Science and Engineering 66, 492 (1992).
- R.J. Levy, G. Golomb, J. Trachy, V. Labhasetwar, D. Muller and E. Topol, Strategies for treating arterial restenosis using polymeric controlled release implants. In: Biotechnology and Bioactive Polymers, C.G. Gebelein, Ed., Edgewater, FL: Lionfire, Inc., 1994, pp. 259-268.
- G. Golomb, M. Mayberg and A.J. Domb, Polymeric perivascular delivery systems. In: Polymeric Site-specific Pharmacotherapy, A.J. Domb, Ed., John Wiley & Sons, NY, 1994, pp. 206-219.
- G. Golomb, D. Moscovitz, I. Fishbein and D. Mishaly, Perivascular polymeric controlled-release therapy. In: Encyclopedic Handbook of Biomaterials and Bioengineering, D. L. Wise, Ed., Marcel Dekker, NY, 1995, pp. 1043-1055.
- J.M. Van Gelder and G. Golomb, The evaluation of bisphosphonates as potential drugs for calcium-related disorders. In: Animal models of human related calcium- metabolic disorders. A. Ornoy Ed., CRC Press, Boca Raton, 1995, pp. 181-206.
- Theme Issue on Intrauterine Drug Delivery, G. Golomb, Ed., Adv. Drug Del. Rev. 17, 1995, pp. 149-204.
- Fishbein, M. Chorny, I. Gati, L. Rabinovich and G. Golomb, Drug delivery systems for the treatment of restenosis, In: Biomaterials and Bioengineering Handbook, D.L. Wise, Ed., Marcel Dekker, NY, 2000, pp.313-335.
- M. Chorny, H. Cohen-Sacks, I. Fishbein, H.D. Danenberg, and G. Golomb, Biodegradable nanoparticles as drug delivery systems for parenteral administration, Tissue Engineering and Novel Delivery Systems, M.J. Yaszemski et.al., Eds., Marcel Dekker, NY, 2004, 393-422.
- E. Cohen-Sela, M. Chorny, and G. Golomb, Nanoparticles for Treatment of Restenosis. In: Nanoparticles for Pharmaceutical Applications, A. J. Domb, Y. Tabata, M. N. V. R. Kumar, S. Farber Eds., ASP, Stevenson Ranch, CA, 2006, pp.123-134.
- H. Epstein, E. Afergan, N. Koroukhov, G. Eisenberg, D. Gutman and G. Golomb, Liposomal bisphosphonates for the treatment of restenosis. In: Liposome Technology, G. Gregoriadis Ed., 3rd ed., vol. II, Informa Healthcare, NY, 2007, pp. 187-206.
- E. Cohen-Sela, V. Elazar, H. Epstein-Barash and G. Golomb, Nano-carriers of drugs and genes for the treatment of restenosis. In: Nanoparticulate Drug Delivery Systems, D. Thassu, M. Deleers and Y. Pathak, Eds., Informa Healthcare, NY, 2007, pp. 235-270.
- E. Breuer, M.S. Chorghade, J. Fischer, and G. Golomb, Glossary of terms related to pharmaceutics (IUPAC Recommendations 2009), Pure Appl. Chem. 81, No. 5, pp. 971
- M. Zepp, T.J. Bäuerle, V. Elazar, J. Peterschmitt, R. Lifshitz-Shovali, H. Adwan, F.P. Armbruster, G. Golomb and M.R. Berger, Treatment of breast cancer lytic skeletal metastasis using a model in nude rats. In: Breast Cancer - Current and Alternative Therapeutic Modalities, E. Gunduz and M. Gunduz Eds., InTech OpenAccess, 2011, pp. 453-488.
- D. Gutman, H. Epstein-Barash, M. Tsuriel and G. Golomb. Alendronate liposomes for antitumor therapy: Activation of T cells and inhibition of tumor growth. In: Nano-biotechnology for Biomedical and Diagnostic Research (Advances in Experimental Medicine and Biology), E. Zahavy, A. Ordentlich, S. Yitzhaki and A. Shaffermaned Eds., Springer, 2011, pp. 165-180.
- D. Gutman and G. Golomb, Liposomal alendronate for the treatment of restenosis, J. Control. Release (in press)
Patents (>29)