· Development of novel bifunctional drugs for the treatment of Alzheimer’s disease and vascular dementia.
· Neurochemical, behavioral and genetic effects of prenatal stress.
Prof. Avri Rubenstein, Hebrew University, Jerusalem
Prof. Michal Lineal, Hebrew University, Jerusalem
Prof. Avraham Nudelman, Bar-Ilan University
Genetics and proteomics of prenatal stress.
Rat behavioral tests: (a) Tests of Spatial and episodic memory; (b) Tests of anxiety and depressive activity.
In vivo and tissue culture models of neuronal damage involving oxidative stress.
Kinetic analysis of cholinesterase inhibition by aromatic carbamates.
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Weinstock, M., The long-term consequences of prenatal stress, Neurosci Biobehav Rev, 32: 1073-1083, 2008.
Weinstock M., Gender differences in the effects of prenatal stress on brain development and behaviour, Neurochem Res 32: 1730-1740, 2007.
Weinstock M., The potential influence of maternal stress hormones on development and mental health of the offspring. (invited review), Brain Behav. Immunity 19: 296-308, 2005.
Weinstock, M., Can the behavioral abnormalities induced by gestational stress in rats be prevented or reversed?, Stress 5: 167-176, 2002
Weinstock M., Alterations induced by gestational stress in brain morphology and behaviour of the offspring, Prog Neurobiol.;65(5):427-51. Review. 2001.
Weinstock M., Effects of maternal stress on development and behaviour in rat offspring. (invited review), Stress 4: 157-167, 2001.
Youdim, M. B.H. Weinstock, M., Molecular basis of neuroprotective activities of rasagline and the anti-Alzheimer drug, TV3326, [ N-propargyl- 3R aminoindan-5-YL -ethyl methyl carbamate], Cell. Mol Biol. 21: 555-573, 2001.
Weinstock, M., Goren, T., Youdim, M.B.H., Development of a novel neuroprotective drug TV3326 for the treatment of Alzheimer’s Disease, with cholinesterase and monoamine oxidase inhibitory activities, Drug Dev. Res. 50: 216-222, 2000.
Phenylethylamine Derivatives: U.S patent No.US 6,251,938, B1: June 26 2001.
Aminindan Derivatives: U.S patent No.US 6,303,650, B1: Oct 16 2001.