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Researchers
  • Prof.  Marta Weinstock-Rosin
Prof Marta Weinstock Rosin
 
Scientific Interest  
        ·       Development of novel bifunctional drugs for the treatment of Alzheimer’s disease and vascular dementia.
 
        ·       Neurochemical, behavioral and genetic effects of prenatal stress.
 
 
      Collaborations  
    Prof. Avri Rubenstein, Hebrew University, Jerusalem
     
    Prof. Michal Lineal,  Hebrew University, Jerusalem
     
    Prof. Avraham Nudelman, Bar-Ilan University
     
     
     
    Laboratory Techniques  
     
    Genetics and proteomics of prenatal stress.
     
    Rat behavioral tests: (a) Tests of Spatial and episodic memory; (b) Tests of anxiety and depressive activity.
     
    In vivo and tissue culture models of neuronal damage involving oxidative stress.
     
    Kinetic analysis of cholinesterase inhibition by aromatic carbamates.
     
    Brain immunohistochemistry
     
     
      
     
    Reviews
     
    Weinstock, M., The long-term consequences of prenatal stress, Neurosci Biobehav Rev, 32: 1073-1083, 2008.
     
    Weinstock M., Gender differences in the effects of prenatal stress on brain development and behaviour, Neurochem Res 32: 1730-1740, 2007.
     
    Weinstock M., The potential influence of maternal stress hormones on development and mental health of the offspring. (invited review), Brain Behav. Immunity 19: 296-308, 2005.
     
    Weinstock, M., Can the behavioral abnormalities induced by gestational stress in rats be prevented or reversed?, Stress 5: 167-176, 2002
     
    Weinstock  M., Alterations induced by gestational stress in brain morphology and behaviour of the offspring, Prog Neurobiol.;65(5):427-51. Review. 2001.
     
    Weinstock  M., Effects of maternal stress on development and behaviour in rat offspring. (invited review), Stress 4: 157-167, 2001.
     
    Youdim, M. B.H. Weinstock, M., Molecular basis of neuroprotective activities of rasagline and the anti-Alzheimer drug, TV3326, [ N-propargyl- 3R aminoindan-5-YL -ethyl methyl carbamate], Cell. Mol Biol. 21: 555-573, 2001.
     
    Weinstock, M., Goren, T., Youdim, M.B.H., Development of a novel neuroprotective drug TV3326 for the treatment of Alzheimer’s Disease, with cholinesterase and monoamine oxidase inhibitory activities, Drug Dev. Res. 50: 216-222, 2000.
     
     
     
     
    Patents
     
    Phenylethylamine Derivatives: U.S patent No.US 6,251,938, B1: June 26 2001.
     
    Aminindan Derivatives: U.S patent No.US 6,303,650,  B1: Oct 16 2001.
     
     
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