Our laboratory studies the profound link between metabolism and cell identity.
We aim to characterize metabolic networks in differentiating cells and regulate cell fate by metabolic modulation.
Using bespoke state of the art analytical instrumentation and bioinformatic tools, we are able to identify thousands of small molecules (metabolites) in a given sample.
Using stem cell technologies and other advanced cellular and multicellular models, we study the influence of the identified metabolic shifts on developmental and pathological processes.
Our platform for metabolic analyses includes state of the art instrumentation (in-house Waters Acquity UPLC H-Class equipped with PDA detector and Xevo X2-XS Q-ToF - High resolution, High Mass Accuracy Q-ToF, and high access to high resolution GC-MS and NMR instruments) and bioinformatic tools, as well as top notch equipment for sample preparation.
This platform results in the most sensitive metabolic analysis, identifying thousands of metabolites in a single analysis.
The Metabolic Maturation of Inner Cell Mass Cells
We use stem cell technology to study the link between metabolism and cell identity.
Using advance 3-dimentional culture, we are modeling the implanted embryo, in an effort to improve the metabolic environment of the embryo and improve embryo implantiation.