Some Useful 2D NMR Experiments
2D NMR spectra provide more information about a molecule than 1D NMR spectra .
The following Table* provides a brief overview of useful 2D NMR experiments for structure determination and the information they provide.
* The Schemas represents in this Table are taken from AVANCE Tutorials
(Heteronuclear Single-Quantum Correlation)
This experiment correlates the chemical shift of a proton with the chemical shift of the directly bonded heteronucleus (usually 13C or 15N).
The obtained spectrum is two-dimensional (2D) with one axis for proton (1H) and the other for a heteronucleus (usually 13C or 15N)
(Heteronuclear multiple-bond correlation spectroscopy)
The experiment correlates long-range coupled 1H and 13C, separated from each other with two or more chemical bonds
The obtained spectrum is two-dimensional (2D) with one axis for proton (1H) and the other for 13C
The experiment is useful for determining the coupling between protons that are connected usually through two to three bond lengths
(Total Correlation Spectroscopy)
The experiment correlates all protons of a spin system
(Nuclear Overhauser Spectroscopy)
NOESY spectra contain information on protons in a molecule that are close in space (less than 5 Å apart.)