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Useful Information
Some Useful 2D NMR Experiments ​
2D NMR spectra provide more information about a molecule than 1D NMR spectra .
The following Table* provides a brief overview of useful 2D NMR experiments for structure determination and the information they provide.  
* The Schemas represents in this Table are taken from AVANCE Tutorials
 
2D HSQC
(Heteronuclear Single-Quantum Correlation)
This experiment correlates the chemical shift of a proton with the chemical shift of the directly bonded heteronucleus (usually 13C or 15N).
 
The obtained spectrum is two-dimensional (2D) with one axis for proton (1H) and the other for a heteronucleus (usually 13C or 15N)
Heteronuclear Single-Quantum Correlation
2D HMBC
(Heteronuclear multiple-bond correlation spectroscopy)
The experiment correlates long-range coupled 1H and 13C, separated from each other with two or more chemical bonds
 
The obtained spectrum is two-dimensional (2D) with one axis for proton (1H) and the other for 13C
Heteronuclear multiple-bond correlation spectroscopy
2D COSY
(Correlation Spectroscopy)​
The experiment is useful for determining the coupling between protons that are connected usually through two to three bond lengths
2D COSY Correlation Spectroscopy
​2D TOCSY
(Total Correlation Spectroscopy)
​The experiment correlates all protons of a spin system
​2D TOCSY​  Total Correlation Spectroscopy
2D NOESY
(Nuclear Overhauser Spectroscopy)​
NOESY spectra contain information on protons in a molecule that are close in space (less than 5 Å apart.)​
2D NOESY Nuclear Overhauser Spectroscopy
 
  
Useful sites
Varian/Agilent site
Bruker site 
 
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