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Dr. Yosefa Avraham
Dr Yosefa Avraham Phone: +97226757547
Room Number: 31 bld 4 floor 1
Academic Unit:  School of Public Health
Research Fields | Teaching |​ Collaborations | Peer Reviewer | Selected Publications |​
     •      Nutrition &Metabolism, from anorexia to obesity 
     •      Nutrition & cognitive function
     •      Endocannabinoids &Disease
     •      Steatosis & Cardiovascular Disease
     •      Leptin as  a survival hormone
     •      Metabolic Syndrome &Depression, Food and Mood
     •      P​ostpartum Depression
     •      Autism
Nutrition in Health and Disease for Pharmacy students
Nutrition and Metabolism to Siud students
Mentor  of 3PhD, 3MD, 15MSc, 20BSc students.
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CollaborationsIsrael, Europe, USA, Japan, Brazil.
Involved in A European consortium which obtained the support of IMI in its 8th Call for developing Functional foods against Alzheimer's disease
Director of eating disorders forum in the Hadassah hospital website
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Peer Reviewer
American J of Gastroentrology; GUT; British J Pharmacology; European J Pharmacology; Brain Behaviour and Immunity; Journal of Hepatology; Pharmaceuticals; Biochemical Pharmacology; Brain Research; Neuroscience Research; European Journal of Nutrition; Behavioural Brain Research; Food Chem; Plos 1;J of Medicinal Food ;American J Clin Nutrition.
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Avraham Y., Bonne OB, Berry E.M., 1996. Behavioral and neurochemical alterations caused by diet restriction - The effect of tyrosine administration in mice. Brain Research 732,133-144.
Van Leeuwen, SD, Bonne OB, Avraham Y., 1997. Separation as a new animal model for self induced weight loss. Physiology and Behavior. 62,1,77-81.
Hao, S., Avraham, Y. Mechoulam, R. and Berry E.M., 2000. Low dose anandamide affects food intake, cognitive function , neurotransmitter and corticosterone levels in diet-restricted mice. European Journal of Pharmacology 392:147-156.
Hao S., AvrahamY., Bonne ,O. and Berry E.M.,. 2000. Separation –induced body weight loss impairment in alternation behaviour and autonomic tone: effects of tyrosine. Pharmacology Biochemistry and Behavior 67, 1-9.
Avraham, Y., Hao S., Mendelson S. ,Bonne, O., and Berry E.M. 2001., Diet restriction in mice causes a decrease in hippocampal choline uptake and muscarinic receptors that is restored by administration of tyrosine: interaction between cholinergic and adrenergic receptors influencing cognitive function. Nutritional Neuroscience.4:153-167
Avraham Y., Hao, S., Mendelson, S., and E.M. Berry., 2001. Tyrosine improves appetite , cognition and exercise tolerance in activity anorexia. Medicine and Science in Sports and Exercise,33, 12:2104-2110
Avraham, Y., Hao S., Mendelson, S., and Berry, E.M. 2002., Hypothalamic-Pituitary-Adrenal responses to weight loss in mice following diet restriction, activity or separation stress :effects of tyrosine. Nutritional Neuroscience, 5(5)327-335.
Shibolet,O., Alper R., , Avraham,Y., Berry,E.M., Ilan,Y., 2002. Immunemodulation of experimental colitis via caloric restriction :role of NK1.1+T cells. Clinical Immunology 105(1) 48-56.
Hanus, L., Avraham Y, Ben Shushan,D., Zolotarev, O., Berry, E.M., and Mechoulam, R., 2003. Short term fasting and prolong semistarvation have opposite effects on 2-AG levels in mouse brain. Brain Research 983, 144-151.
Gur, E., Newman, M., Avraham,Y., and Berry,E.M., 2003 The effect of diet restriction on basal 5HT levels in hippocampus and hypothalamus and the sensitivity of 5-HT1A and 5-HT1B. Nutritional Neuroscience. 6, 169-175.
Bonne O, Avraham Y, Katz M, Berry EM. 2003. Does short-term diet restriction in mice precipitate the development of anorexia? Nutritional Neuroscience 6, 197-199.
Avraham Y, Ben-Shushan D, Breuer A , Zolotarev O, Okun A, Fink N, Katz V and Berry, E.M., 2004. Very low doses of delta-8 (THC) increase food consumption and alter neurotransmitter levels following weight loss. Pharmacology Biochemistry and Behaviour 77:675-684.
Avraham Y., Ben Menachem A., Okun A., Zolotarav O., Abel N. ,Mechoulam R. and E. M. Berry., 2005. Effects of the endocannabinoid noladin ether on body weight , food consumption, locomotor activity , and cognitive index in mice. Brain Research Bulltin, 65:117-123.
Avraham Y, Israel E, Gabba E , Okun A, Zolotarev O, Zilberman I, Ganzburg V, Dagon Y, Magen I, Vorobia L, Pappo O, Mechoulam, R, Ilan Y and Berry, E.M., 2006. Endocannabinoids affect neurological and cognitive function in thioacetamide-induced hepatic encephalopathy in mice. Neurobiology of Disease 21, 237-245.
Dagon Y , Avraham Y, Magen I, Gertler A , Ben-Hur T and Berry EM. 2005. Nutritional status, cognition and survival - a new role for leptin and AMPK. J Biol Chem. 23; 280(51):42142-42148.
Dagon Y, Avraham Y and Berry EM., 2006. AMPK activation regulates apoptosis, adipogenesis, and lipolysis by eIF2α in adipocytes. BBRC 34043-34047.
Dagon Y, Avraham Y , Ilan Y, Mechoulam R and Berry EM., 2007.Cannabinoids ameliorate cerebral dysfunction following liver failure via AMP-activated protein kinase. FASEB J. 21(10): 2431-2441
Dagon Y, Avraham Y , Link G, Zolotarev O, Mechoulam R and Berry EM., 2007. The synthetic cannabinoid HU-210 attenuates neural damage in diabetic mice and hyperglycemic pheochromocytoma PC12 cells.Neurobiol Dis. 2007 .27(2):174-81.
Avraham Y, Magen I, Zolotarev O, Vorobiav L, Pappo O, Ilan Y, Elliot M. Berry EM and Ackerman Z.2-arachidonoylglycerol, an endogenous cannabinoid receptor agonist, in various rat tissues during the eveloution of experimental cholestatic liver disease . Prostaglandins Leukot Essent Fatty Acids. 2008 79(1-2):35-40.
Avraham Y, Zolotarev O , Grigoriadis N, Pautahidis T, Magen I, Vorobiav L, Zimmer A, Ilan Y,Mechoulam R, and Berry EM. Cannabinoids and Capsaicin improve liver function following Thioacetamide –induced acute injury in mice. American J Gastroentrol 2008 Dec;103(12):3047-56.
Iddo Magen, Yosefa Avraham, Zvi Ackerman, Olga Zolotarev, Lia Vorobiev, Raphael Mechoulam and Elliot M. Berry. Cannabidiol ameliorates cognitive and motor impairments in mice with cholestatic liver disease. J of Hepatology 2009 51(3) 528-534.
Avraham Y, Grigoriadis N, Magen I, Pautahidis T, Vorobiav L, Zolotarev O , Ilan Y,Mechoulam R, and Berry EM. Capsaicin affects brain function in a model of hepatic encephalopathy associated with Fulminant hepatic failure in mice British J of Pharmacology 2009 158,896-906.
Magen I ,Avraham Y, Ackerman Z, Vorobiav L, Mechoulam R, and Berry EM. Cannabidiol ameliorates cognitive and motor impairments in bile-duct ligated mice via 5-HT1A receptor activation. British J of Pharmacology 2010 159:950-957.
Avraham Y, Davidi N, Porat M, Chernoguz D, Magen I, Vorobeiv L, Berry EM, Leker RR. Leptin reduces infarct size in association with enhanced expression of CB2, TRPV1, SIRT-1 and leptin receptor. Curr Neurovasc Res 2010 7:136-143.
Avraham Y, Saidian M, Burston J J, Mevorach R, Vorobiev L, Magen I, Kunkes K; Borges B; Lichtman,AH Berry EM. Fish oil promotes survival and protects against cognitive decline in severely undernourished mice by normalizing satiety signals.J Nutritional Biochemistry 2011 Aug;22(8):766-76.
Y Avraham, N C Grigoriadis, T Poutahidis, L Vorobiev, I Magen, Y Ilan, R Mechoulam and Berry EM .Cannabidiol improves brain and liver function in a Fulminant Hepatic Failure-induced model of hepatic encephalopathy in mice British J of Pharmacology 2011 Apr;162(7):1650-8.
Borges BC, Rorato R, Avraham Y, da Silva LE, Castro M, Vorobiav L, Berry EM, Antunes-Rodrigues J, Elias LL. LEPTIN RESISTANCE AND DESENSITIZATION OF HYPOPHAGIA DURING PROLONGED INFLAMMATORY CHALLENGE. Am J Physiol Endocrinol Metab. 2011 May;300(5):E858-69.
Avraham Y, Davidi N, Lassri V, Vorobiev L, Kabesa M, Dayan M, Chernoguz D, Berry E, Leker RR. Leptin Induces Neuroprotection Neurogenesis and Angiogenesis after Stroke. Curr Neurovasc Res. 2011 Nov;8(4):313-22.
Avraham Y, Amer J, Doron S, Abu-Tair L, Mahamid M, Khatib A, Berry EM, Safadi R. The direct profibrotic and indirect immune antifibrotic balance of blocking the cannabinoid 2 receptor. Am J Physiol Gastrointest Liver Physiol. 2012 Jun 15;302(12):G1364-72.
Y. Avraham, M. Dayan, V. Lassri, L. Vorobiev, N. Davidi, D. Chernoguz, E. Berry,1 and R.R. Leker.Delayed Leptin Administration After Stroke Induces Neurogenesis and Angiogenesis. Journal of Neuroscience Research, 2013 Feb;91(2):187-95
Avraham Y, Katzhendler J, Vorobeiv L, Merchavia S, Listman C, Kunkes E, Harfuch F, Salameh S, Ezra AF, Grigoriadis NC, Berry EM, Najajreh Y. Novel acylethanolamide derivatives that modulate body weight through enhancement of hypothalamic Preopiomelanocortin (POMC) and/or decreased Neuropeptide Y (NPY). J Med Chem. 14;56(5):1811-29.2013 Feb 5.
Reviews,commentaries, hypotheses, editorials
Avraham Y, Dagon Y, Magen I and Berry E.M., 2005."Models of Anorexia" Review in "Drug Discovery Today" ,Vol 2;3. Review.
Gabbay E., Avraham Y., Ilan Y., Israeli E C and Berry EM., 2005. Endocannabinoids and Liver Disease, Review. Liver Int. Oct; 25(5):921-926.
Mechoulam R ,Berry EM, Avraham Y, Di Marzo V. and Fride E. 2006.Endocannabinoids, feeding and suckling – a personal overview. in: International J Obesity. Suppl 1:S24-8. 3.640;9/59 C;.Review.
Dagon Y, Avraham Y and Berry EM.2007 . Diet restriction and the fruits of the tree of life. CellScience Reviews vol 4(2), ISSN 1742-8130, 2007
Magen I ,Avraham Y, Berry E.M., and Mechoulam R .Endocannabinoids in liver disease and hepatic encephalopathy. Curr Pharm Des. 2008; 14(23):2362-9. Review.
Avraham Y and Nachum S.Management of obesity in menopause :Lifestyle modification,medication,bariatric surgery &personalized treatment.Curr Topic in Menopause .2013 Chapter 7.
5 patents
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