Application of
engineered viruses for the therapy of a variety of diseses
The focus of my research for many years has been to apply viruses, that in nature cause diseases, into efficient vectors for the therapy of a variety of diseases. This is done by genetic engineering certain viruses to carry therapeutic genes and by targeting the viruses to infect selectively diseased tissues.
1) We have applied this expertise to the development of the Bio-Pump technology for the sustain delivery of hormones, such a Erythropoitein EPO, to patients with kidney failure and consequent chronic anemia.
2) We developed a unique oncolytic virus (termed NDV-HUJ) that selectively infect and destroy tumor tissues and have carried the experimentation's through the preclinical and early phase 1/2 human clinical trial. We currently expending the studies both at developing new a selective oncolytic viruses and carry on with the clinical trials.