Identification, characterization and exploitation of short linear motifs in the ubiquitin system.

Part of the UBIMOTIF consortium (EU Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 860517).

The lab: the Furman lab (www.cs.huji.ac.il/~fora) studies the biophysical basis of peptide/short motif-mediated protein interactions and their regulatory biological roles. We develop cutting edge tools to model the structural details of these interactions (e.g. Rosetta FlexPepDock), and use these structures for the identification of natural substrates, as well as the design of modulators of customized specificity. Complemented by biophysical characterization, we aim at building a model of the atomic details of regulation, which forms the basis for the design targeted manipulations, to be used for the study of the biological importance of an interaction.

The Project: You will apply and further develop our structure-based approaches to characterize, design, and manipulate key ubiquitination (E3 Ligase) and deubiquitination (DUB) substrate specificities. In complementation to large-scale experimental detection of substrates and bioinformatic definition of sequence binding motifs, we will establish the structural basis of these interactions.

See the announcement on our webpage (www.cs.huji.ac.il/~fora) for more details.

Deadline for application: January 3rd