The Herbert
and Dorothy Nadolny Cardio-Metabolic Disease Research Hub
August 2019
The metabolic disease research hub
organizes a group of scientists at IMRIC, that are performing collaborative
high-quality research on cardio-metabolic diseases, in particular diabetes and
its complications. Research projects include, among others:
- Embryonic
development of the heart and implications for adult cardiac plasticity and
regeneration
- Embryonic
development of the pancreas and the programming of embryonic stem cells to
generate transplantable beta cells for the cure of diabetes.
- Adult
beta cell dynamics and regenerative medicine for diabetes.
- Mechanisms
of insulin resistance
- The
impact of bariatric surgery on cardio-metabolic disease
- ER
stress as a determinant of beta cell failure in diabetes
- Role
of natural killer cells in the development of autoimmune diabetes
- Alternative
splicing as a determinant of beta cell function and insulin action
- Epigenetic
aberrations in type 2 diabetes
- Novel
effects of blood vessels on organ development and function
- Cell-free
circulating DNA for diagnosis and monitoring of metabolic diseases
- Role
of cellular senescence in beta cell biology and pathology
A strength of this group lies in the
diverse expertise of its members, many of whom are young faculty. By bringing
together knowhow from cardiovascular biology, embryology, molecular biology,
advanced transgenic technology, epigenetics and clinical sciences, this hub
greatly enhances the quality of cardio-metabolic disease research and
its eventual clinical impact.
This hub operates on an everyday basis to
advance the study of cardio-metabolic diseases, metabolic syndrome and
diabetes. This includes joint group meetings and journal clubs, seminars of
invited guests and special research days. The hub attempts to attract
additional funding for joint multidisciplinary projects and for the purchase of
advanced equipment needed for this type of research. Another goal of the hub is
to establish a “library” of engineered animal models and vectors used for the
study of the pathophysiology of metabolic disease.
Members of the
metabolic hub
Yuval
Dor (head) Diabetes, novel approaches
for diagnosis of cardiometabolic disease
Benjamin Glaser Diabetes and hyperinsulinism
Gil Leibowitz ER
stress in pancreatic beta cells
Zvi Granot Modulation
of neutrophil function in metabolic diseases
Danny Ben-Zvi Systems
biology of metablic disease
Shlomo Sasson Insulin
action
Abraham
Fainsod The connection between abnormal
retinoic acid biosynthesis and neurodevelopment disorders
Ann
Saada Reisch Inborn errors of metabolism
- mitochondrial and lysosomal diseases
Rotem Karni Regulation
of glucose metabolism by alternative splicing
Jacob
Bar-Tana 1) Upstream molecular
drivers of the Metabolic Syndrome 2) All-in-One prospective drug for type 2
diabetes
Eli
Keshet Blood vessels and
cardiometabolic disease. Heart development.
David
Zangen Beta cell gene expression
in diabetes and hyperinsulinism
Sarah
Zangen Beta cell metabolism focusing
on mitochondrial OXPHOS and its role in glucose stimulated insulin secretion
Danielle
Melloul Transcriptional regulation
of pancreatic beta cells
Ofer Mandelboim Metabolism,
metabolic diseases and innate immunity
Rami Aqeilan Wwox
and glucose metabolism in cancer
Yossi Tam Role
of the peripheral endocannabinoid system in obesity, diabetes and the metabolic
syndrome
Hilla Knobler β-cell
function in diabetics of Yemenite origin
Hypoglycemia
post bariatric surgery
