Control of prokaryotic ribosomal gene expression. Cloning of the promoter and terminator regions of the ribosomal gene. Structure and control of ribosomal RNA genes in mycoplasma. Structure-function relationship and cellular factors in the control of rRNA gene expression. Structure of relA operon, control of expression. Dissection of relA gene product: structure-function relationship. relA gene of E. coli, rel/spo of B. subtilis and Thermus thermophillus and Deinococus. Study of chromosomal addiction module of E. coli, programmed cell death in E. coli. Importance of ppGpp in the formation of persistent bacteria. Studies of HipAB mode of action.