Alzheimer's disease and other dementias - developing novel therapeutic approaches
Research in my lab focuses on therapies for Alzheimer's disease (AD) and other dementias (such as frontotemporal dementia). For this purpose we generated novel mouse models, which mimic authentically the diseases in the dementia patients. Using the animal models we are developing therapeutic approaches, at the cutting edge of the AD research. This includes:
- Developing a vaccine which clears the brain of dementia patients from the toxic tau protein accumulation, and thereby stops the cognitive decline.
- Identifying dementia protective properties among existing drugs (in use in other diseases), and among herbal extracts (natural products), since such substances have the potential to become commercially available against dementia within a short time with low cost.
- Enriching the fluid which bathes the brain in dementia patients with lively bioactive fluid. This novel approach may be suitable for a wide range of degenerative diseases in the nervous system, including amyotrophic lateral sclerosis (ALS).
- Neurogenetic aspects of neurodegenerative diseases.