The research in my Laboratory focuses on the mammalian cell cycle using genomic techniques. We study several aspects of the cell cycle, including i) the sources of the non-genetic variability between cells in the duration of the cell cycle. ii) The changes in the chromatin structure along the cell cycle and particularly during mitosis. And iii) the organization of DNA replication. We are especially interested in the changes in the replication program during cancer transformation and during replication stress and we are applying both genomics and single cell (DNA combing) techniques to address those questions.