Modifications of chromatin structure are known to occur following changes in cellular environment and as an adaptation to altered physiological conditions. In our lab we seek to broaden the understanding of cellular plasticity by studying the regulatory mechanisms of alternative pre-mRNA splicing in physiological and pathological contexts. We wish to pin point the impact of alternative splicing regulation in response to a modified chromatin environment and to understand what part of the cellular response to the physiological cue is mediated by alternative splicing.
