Patents
Meir Bialer, Salim
Hadad, Yaacov Herzig, Jeff Sterling, David Lerner, Mitch Shirvan. Derivatives of
valproic acid amide and 2-valproenoic acid amide, method of making and use
thereof as anticonvulsant.
-U.S. Patent No.
5,585,358. Issued 17 December, 1996.
-IL Pat No.
110216 issued 21/10/1994
-IL Pat No.
133891 (divisional pat) issued 13/05/2003
-EP Pat No.
0659174 issued 10/02/1999 valid in CH,DE,FR,ES,GB
-NZ Pat No.
269643 issued 17/04/1997
-Jp Pat No.
3856464 issued 22/09/2006
-CA Pat No.
2,143,636, issued 01/05/2007
-AU Pat No.
673766 issued 12/03/1997
-Chinese Pat No.
ZL94190471.7 issued 23/04/2003
-Chinese Pat
(DIV) No. ZL02105358.8 issued 04/02/2009
Meir Bialer, Arie Dagan, Sherbel Sussan. Anticonvulsant drugs and
pharmaceutical compositions thereof.
-U.S. Patent No. 6,028,102 (Issued: 22 February, 2000).
-IL Patent
Application No. 137740.
Meir Bialer, Boris Yagen, Niv Papo. Active derivative of valproic acid for
the treatment of neurological and psychotic disorders and a method for their
preparation.
-U.S. Patent No. 6,323,365 (Issued: 27 November, 2001).
-European Patent
No. 1176138, issued 01/12/2004, valid in GB, DE, FR, IT, SP and CH
-IL Patent No.
130666, issued 15/12/2002
Jeff Sterling, Yaacov Herzig, Meir Bialer, Abdullah Haj-Yehia, Boris Yagen.
Derivatives of tetramethylcyclopropane.
-U.S. Patent No. 5,880,157 (Issued: 9 March, 1999).
-German Patent
No. 19518497.5 (Issued: 5 August, 2004).
-IL Pat No.
108595, issued 27/12/1998
Meir Bialer, Boris Yagen, Ofer Spiegelstein, Michael Roeder and Volker
Schurig. Amelioration of neurological disorders by the administration of
(2R),(3S) and/or (2S),(3S) stereoisomers of valnoctamide.
-U.S. Patent No. 6,417,399 (Issued: 9 July, 2002).
-European
Patent No. 98900346.2 validated in Germany, France, England, Spain, Italy,
Switzerland, Greece, Belgium, Netherlands
and Sweden.
-IL Patent No.
120006 (Issued: 7 March 1999).
Meir Bialer, Ofer Spiegelstein, Boris Yagen. Propylisopropyl acetic acid
and propylisopropyl acetamide stereoisomers, a method for their synthesis and
pharmaceutical compositions containing them.
-U.S. Patent No. 6,630,602, issued 07/10/2003
-European Patent
No. 1077926, issued 23/02/2005, valid in GB, FR, DE, CH
-IL Patent No.
124118 (stereoisomers) issued 21/12/2007
-IL Patent
No.136030 issued 12/05/2007 (racemic mixtures).
-US Pat No.
6,969,732, issued 29/11/2005.
Amnon Sintov, Andrew Volosov, Meir Bialer, Boris Yagen. Pharmaceutical
compositions containing low-melting waxes.
-U.S. Patent Application Serial No. 09/743,260 (Filing date: 8
January, 2001).
-European Patent
application No. 99928200.7
-IL Patent
Application No. 125244.
Meir Bialer, Nina Isoherranen, Boris Yagen. Derivatives of valproyl
taurinamide, method of making and use thereof as anticonvulsant and CNS active
agents.
-US Pat No. 6,958,416 issued 25/10/2005
Meir Bialer, Nina Isoherranen, Boris Yagen. Derivatives and pharmaceutical
compositions of N-Hydroxymethyl Tetramethylcyclopropyl-Carboxamide having
anti-epileptic, neurological and CNS activity, and method for their preparation.
-IL Patent No. 147953 issued 13/04/2008
-International
Application No. PCT/IL02/0150 (International filing date: 29 December, 2002)
-US pat No.
6,960,687 issued 01/11/2005
Meir Bialer, Boris Yagen, Dan Kaufmann, and Eyal Sobol. New Amide
derivatives of 2,2,3,3-tetramethylcyclopropane carboxylic acid, a method their
synthesis and pharmaceutical compositions containing them.
-IL Patent Application No. 154694 (Filing date: 28/02/2003), and
IL Patent Application No.157751 (Filing date: 4/09/2003).
-International
Application No. PCT/IL04/000193. (Filing date: 26 February, 2004).
-EP pat no.
1603891, issued 28/05/2008 valid in DE, GB, CH & FR
Meir Bialer, Boris Yagen, Haim Pinchas Belmaker, Galila Agam, Galit
Shaltiel. Use of 2,2,3,3, tetramethylcyclopropane carboxylic acid derivatives
for treating psychiatric disorders.
-EP pat No. 1626710, issued 01/10/2008 valid in GB, FR, DE and
Switzerland.
-Pending patent
applications in : US, IL, CA & JP
Meir Bialer, Boris Yagen, Sara Eyal, Yoram Altschuler. Topiramate
compositions useful for the treatment of cancer.
-IL Patent Application No.156888 (Filing Date: 29 June
2003).
Meir Bialer, Boris Yagen , Ilan Winkler, Marshal Devor. Compounds useful
for treating neurological disorders.
-Pending patent applications in Israel, Europe and US
Meir Bialer, Boris Yagen , Sara Eyal. Use of valproyl hydroxamic acid as an
antineoplastic agent.
-IL Patent Application No. 162263 (Filing Date: 31 May
2004)
Meir Bialer, Mitchell Shirvan. Use of Derivatives of Valproic Acid and
2-Valproenic Acid Amides for the Treatment of Mania Bipolar Disorder.
-US Pat No. 6,555,585, issued 29/04/2003
-NZ Pat No.
532917, issued 03/10/2005
-Korean Pat No.
10-0843703, issued 27/06/2008
-MX Patent No.
233952, issued 25/01/2006
Pending paten
applications in Canada, China, Europe, Isral, Japan , Australia.
Meir Bialer, Mitchell Shirvan. Use of Derivatives of Valproic Acid Amides
and 2-Valproenoic Acid Amides for the Treatment of Pain and /Or Headaches
Disorders
-EP Pat No. 1311256, issued 17/08/2005 valid
in FR,UK,EI,IT,NL,BE,CH,DE,ES
-Chinese Pat No.
01817134.6, issued 18/02/2009
-Korean Pat No.
10-0851955, issued 06/08/2008
-South African
pat No. 2003/1427, issued 28/04/2004
-MX Pat No.
239154, issued 02/08/2006
Pending patent
applications in US, JP, AU, and IL
Meir Bialer, Boris Yagen , Neta Pessah . New -halo and -alkyl CNS-Active
Analogues of Valproic Acid.
Pending Patent applications in US and Israel , from PCT WO
008/102348 filed 19/02/08
Meir Bialer, Boris Yagen, Shimshoni Jakob Avi. ACYL-UREA DERIVATIVES AND
USES THEREOF PCT app PCT/IL2008/000870, WO 2009/001356 filed 25/06/2008
