Past research projects have focused on the mechanism of food-induced hemolytic crisis in G-6-PD deficiency (Favism), and the role of transition metals in injurious processes in biology and medicine involving free radicals—which are either spontaneous (e.g. aging or ischemic heart disease) or induced by drugs, foods, xenobiotics or radiation. He has also investigated the effects of burn injury to skin and eye tissues by toxic chemicals including warfare agents. Recently he focused on novel mechanisms of protection of the ischemic heart, brain and retina. These studies have been extended to the diabetic heart.