​Research Projects

Cancer Immunotherapy

TIGIT serves as an inhibitory receptor on human NK cells

Stanietsky et al. PNAS. 2009

Company Founded: TIGIT and PVR blocking-antibodies as novel immune checkpoint inhibitors with funding from Integra and Orbimed

Bacteria

Fusobacterium nucleatum protects colorectal cancer from immune attack

Gur et al. Immunity. 2012

NK cells respond to urinary tract infection, and UPEC has learned to adhere to and kill NKs Gur et al. Cell Host and Microbe. 2013.

Company Founded: UPEC for treatment of bladder cancer with funding from Integra

Viruses

Viral micro-RNAs can target human genes

Stern-Ginossar et al. Science. 2007

HCMV successfully targets a human escape variant in order to avoid NK attack

Seidel E et al. Cell Reports. 2015

Molecular Biology

RNA binding proteins can control expression levels of NK ligands

Nachmani et al. Nat Communications. 2014

IMP3 aids viral escape by downregulating NK activating ligands

Shmeidel et al. Elife. 2016

Fungi

NKs recognize and kill fungi, including Candida glabrata

Vitenshtein et al. Cell Host Microbe. 2016