1. Activation of receptor mediated phagocytosis of degenerated myelin in microglia and macrophages: complement receptor-3, scavenger receptor-AI/II, Galectin-3 and Syk.
2. The role of cytoskeleton (e.g. F-actin, myosin, Rac, Rho/ROCK and MLCK) in phagocytosis by microglia and macrophages.
3. The regulation of myelin phagocytosis by immune inhibitory receptor SIRPa and CD47 in microglia and macrophages.
4. The regulation of Wallerian degeneration, regeneration and functional recovery by immune inhibitory receptor SIRPa and CD47.