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Scientific Activity

Research was  focused on studying  the physiological functions  of naturally occurring polyamines (spermine, spermidine and putrescine). Special emphasis was given to elucidating their role in promoting growth and malignant transformation. It has been found that they activate protein kinases which are involved in signal transduction. This resulted in stimulated expression of the nuclear oncogenes fos. jun and myc
Based on these studies a new method for determining the sensitivity of cancer cells to chemotherapy and radiotherapy was developed. This in vitro chemosensitivity test, was successfully applied for  predicting the optimal treatment for hematological cancer patients. As a result, undesired  toxic  side effects of anti cancer agents could be  reduced.
The mode of anticancer activity of polyphenols derived from green tea was also elucidated.