Research Interests

Protein-protein interactions are at the heart of any functioning cell and organism. We are interested in elucidation of the structural details that allow for the complexity observed in protein interactions and function.

High-resolution modeling of protein-protein interactions. We use RosettaDock to create high-resolution models of protein-protein interactions. RosettaDock is a well-established docking protocol for the modeling of protein complexes starting from the free monomers that explicit models conformational changes at the interface that occur upon binding (read more). With this protocol we have been able to create high-resolution models in many of the CAPRI rounds (read more). Thus, RosettaDock can be used to create highly accurate models of protein complex structures that serve as starting point for the targeted manipulation of interactions by structure-based computational design, thereby opening an exciting new field of applications. (read more). In our current work, we extend our existing protocol to a variety of related applications, such as the prediction of protein-peptide binding, protein motion and binding specificity.