Professor Rotem Karni

Current Projects

Identification and characterization of splicing changes that occur during cancer progression and their contribution to the metastatic process.
Development of new RNA-based therapies for neurodevelopmental genetic diseases caused by mutations in the splicing factor HNRNPH2 and PCDH19.
Development of specific splicing factor inhibitors (decoy oligonucleotides) as novel anti-cancer therapy for AML and breast cancer.
Enhancing immunotherapy by splicing modulation.
Modulation of m6A RNA modification to inhibit mRNA degradation in genetic diseases and cancer.