Karni, R., Elisa de-Stanchina, David Mu, Scott Lowe, Rahul Sinha and Adrian Krainer. (2007) The gene coding for the splicing factor SF2/ASF is a proto-oncogene. Nat Struct Mol Biol. 14(3):185-93.
Karni, R., Hippo, Y., Lowe, S.W. and Krainer, A. (2008) The splicing factor oncoprotein SF2/ASF activates mTORC1. Proc. Natl. Acad. Sci. USA, 105:15323-7.
Golan-Gerstl, R., Cohen, M., Shilo, A., Suk-Suh, S., Bakacs, A., Coppola, L. and Karni, R. (2011). Splicing factor hnRNP A2/B1 regulates tumor suppressor gene splicing and is an oncogenic driver in glioblastoma. Cancer Res. 71, 4464-72.
Eshar, S., Allemand, E., Sebag, A., Glaser, F., Muchardt, C., Mandel-Gutfreund, Y., Karni, R. and Dzikowski R. (2012). A novel Plasmodium falciparum SR protein is an alternative splicing factor required for the parasites' proliferation in human erythrocytes. Nucleic Acids Res. 40: 9903-16.
Cohen-Eliav, M., Golan-Gerstl, R., Siegfried, Z., Andersen, CL,. Thorsen, K., Ørntoft, T.F,. Mu, D. and Karni, R. (2013). The splicing factor SRSF6 is amplified and is an oncoprotein in lung and colon cancers. J Pathol. 229: 630-9.
Ben Hur, V., Denichenco, P., Maimon, A., Krainer, A., Davidson, B. and Karni, R. (2013). S6K1 alternative splicing modulates its oncogenic activity and regulates mTORC1. Cell Reports, 3: 103–115.
Shimoni-Sebag, A., Lebenthal-Loinger, I., Zender, L. and Karni, R. (2013). RRM1 domain of the splicing oncoprotein SRSF1 is required for MEK1-MAPK-ERK activation and cellular transformation. Carcinogenesis. 34: 2498-504.
Siegfried, Z., Bonomi, S., Ghigna, C. and Karni, R. (2013). Regulation of the Ras-MAPK and PI3K-mTOR signalling pathways by alternative splicing in cancer. Int J Cell Biol. (Review). 2013: ID 568931.
Maimon, A., Mogilevsky, M., Shilo, A., Golan-Gerstl, R., Obiedat, A., Ben Hur, V., Lebenthal-Loinger, I., Stein, I., Reich, R., Beenstock, J., Zehorai, E., Andersen, C.L., Thorsen, K., Ørntoft, T.F., Davis, R.J., Davidson, B., Mu, D. and Karni, R. (2014). Mnk2 alternative splicing modulates the p38-MAPK pathway and impacts Ras-induced transformation. Cell Reports. 7: 501-13.
Shilo, A., Ben Hur, V., Denichenko, P., Stein, I., Pikarsky, E., Rauch, J., Kolch, W., Zender, L. and Karni, R. (2013) Splicing Factor hnRNP A2/B1 activates the Ras-MAPK-ERK pathway controlling A-Raf splicing in hepatocellular carcinoma development.RNA. 20: 505-15.
Shilo, A., Siegfried, Z. and Karni, R. (2014). The role of splicing factors in deregulation of alternative splicing during oncogenesis and tumor progression. Molecular and Cellular Oncology. (Review). 1: e970955
Danan-Gotthold, M., Golan-Gerstl, R., Eisenberg, E., Meir, K., Karni, R. and Levanon, E.Y. (2015). Identification of recurrent regulated alternative splicing events across human solid tumors. Nucleic Acids Res. 43:5130-44.
Malakar P, Chartarifsky L, Hija A, Leibowitz G, Glaser B, Dor Y, Karni R. (2016). Insulin receptor alternative splicing is regulated by insulin signaling and modulates beta cell survival. Sci Rep. 6:31222.
Malakar P, Shilo A, Mogilevsky A, Stein I, Pikarsky E, Nevo Y, Benyamini H, Elgavish S, Zong X, Prasanth KV, Karni R. (2017). Long Noncoding RNA MALAT1 Promotes Hepatocellular Carcinoma Development by SRSF1 Upregulation and mTOR Activation. Cancer Res. 77:1155-1167.
Kozlovski, I., Siegfried, Z., Amar-Schwartz, A. and Karni, R. (2017). The role of RNA alternative splicing in regulating cancer metabolism.Hum Genet.136:1113-1127. (Review).
Siegfried, Z. and Karni, R. (2018). The role of alternative splicing in cancer drug resistance. Curr Opin Genet Dev. 48:16-21. (Review).
Mogilevsky, M., Shimshon, O., Kumar, S., Mogilevsky, A., Keshet, E., Yavin, E., Heyd, F. and Karni, R. (2018). Modulation of MKNK2 alternative splicing by splice-switching oligonucleotides as a novel approach for glioblastoma treatment. Nucleic Acids Res. 46:11396-11404.
Malakar, P., Stein, I., Saragovi, A., Winkler, R., Stern-Ginossar, N., Berger, M., Pikarsky, E. and Karni, R. (2019). Long Noncoding RNA MALAT1 regulates cancer glucose metabolism by enhancing mTOR-mediated TCF7L2 translation. Cancer Research. 79:2480-2493.
Denichenko, P., Mogilevsky, M., Cléry, A., Welte, T., Biran, J., Shimshon, O., Barnabas, G.D., Danan-Gotthold, M., Kumar, S., Yavin, E., Levanon, E.Y., Allain, F.H., Geiger, T., Levkowitz, G. and Karni, R. (2019). Specific inhibition of splicing factor activity by decoy RNA oligonucleotides. Nature Communications. 10:1590.
