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​Biography

I am a biologist with multidisciplinary training in biology, biophysics, and synthetic biology. My research interests center on developing novel synthetic biology platforms for biomedical applications, and to study clinically relevant biological questions.
>During My Ph.D., I pioneered the very first synthetic gene-circuit that actuated Boolean-logic to precisely target cancer cells by the integrated activity of multiple tumor-specific promoters, namely Dual-Promoter Integrator (DPI). We later implemented the DPI to demonstrate that tumor heterogeneity mediates inherent sensitivity–specificity tradeoff in cancer targeting by synthetic circuits.
>In my postdoctoral research, I developed several novel synthetic biology platforms. First, I developed synthetic RNA-based gene circuits for cancer immunotherapy that precisely identify cancer cells and drives the tumor-specific expression of immunostimulatory outputs. This approach could potentially be implemented as powerful new immunotherapy modalities, and to study tumor immunology. In addition, I developed a high-throughput screening approach for identifying Synthetic Promoters with Enhanced Cell-State Specificity (SPECS) that could potentially provide compact synthetic promoters with enhanced specificity to virtually any cell-state, without prior gene regulation or transcriptome data. Finally, I developed an integrated RNA and CRISPR/Cas gene regulation toolkit that enabled easy, customizable, and scalable manipulation of human cells. This approach enabled a shift from the construction of only constitutively active single-layer taCas9 based circuits to the engineering inducible multi-layer cascades and synchronized networks.

Academic Appointments

2018-Present
Senior Lecturer (Assistant Professor).
The Institute for Medical Research Israel-Canada, Hadassah Medical School.
The Hebrew University of Jerusalem
2011-2018
Postdoctoral research, The Massachusetts Institute of Technology, Cambridge, MA.
The MIT Synthetic Biology Center, Research Laboratory of Electronics
Advisor: Prof. Timothy K. Lu
2009-2011
Postdoctoral research, The Weizmann Institute of Science, Rehovot, Israel.
Faculty of Chemistry, Department of Materials and Interfaces.
Advisor: Prof. Roy Bar-Ziv
2004-2009
Ph.D., The Weizmann Institute of Science, Rehovot, Israel.
Faculty of Chemistry, Department of Materials and Interfaces.
Advisor: Prof. Roy Bar-Ziv
2001-2003
M.Sc., The Weizmann Institute of Science, Rehovot, Israel.
Faculty of Biology, Department of Molecular Cell Biology.
Advisor: Prof. Varda Rotter
1998-2001
B.Sc., Biology, Tel Aviv University, Israel.

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